Displaying drugs 101 - 125 of 166 in total
Estradiol dienanthate
Estradiol Dienanthate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Metacycline
A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.
Approved
Investigational
Trioxsalen
Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of...
Approved
Matched Description: … explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA …
Zinc chloride
Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes. Zinc chloride was granted FDA approval before 26 June 1986.
Approved
Investigational
Zinc acetate
Approved
Investigational
mRNA-3745
mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs encoding human glucose 6-phosphatase (G6Pase).
Investigational
Matched Name: … mRNA-3745 …
Matched Description: … mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs …
Matched Description: … mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs …
mRNA-3927
mRNA-3927 is an investigational mRNA therapy that consists of two mRNAs that encode for the alpha and beta subunits of the mitochondrial enzyme propionyl-CoA carboxylase (PCC) encapsulated within a lipid nanoparticle (LNP). Developed by Moderna Inc., it is being investigated for the treatment of propionic acidemia.
Investigational
Matched Name: … mRNA-3927 …
Matched Description: … mRNA-3927 is an investigational mRNA therapy that consists of two mRNAs that encode for the alpha and …
Matched Description: … mRNA-3927 is an investigational mRNA therapy that consists of two mRNAs that encode for the alpha and …
mRNA-1345
mRNA-1345 is an investigational RSV vaccine.
Investigational
Matched Name: … mRNA-1345 …
Matched Description: … mRNA-1345 is an investigational RSV vaccine. …
Matched Description: … mRNA-1345 is an investigational RSV vaccine. …
mRNA-3705
mRNA-3705 is an investigational mRNA encoding methylmalonic CoA mutase (MUT) enzyme. Developed by Moderna TX Inc., it is being investigated for the treatment of methylmalonic academia.
Investigational
Matched Name: … mRNA-3705 …
Matched Description: … mRNA-3705 is an investigational mRNA encoding methylmalonic CoA mutase (MUT) enzyme. …
Matched Description: … mRNA-3705 is an investigational mRNA encoding methylmalonic CoA mutase (MUT) enzyme. …
mRNA-3351
mRNA-3351 is a modified mRNA encoding the UGT1A1 gene. Developed by Moderna, it is currently being investigated as the treatment for Crigler-Najjar syndrome
Experimental
Matched Name: … mRNA-3351 …
Matched Description: … mRNA-3351 is a modified mRNA encoding the UGT1A1 gene. …
Matched Description: … mRNA-3351 is a modified mRNA encoding the UGT1A1 gene. …
ChulaCov19 mRNA vaccine
The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration with the University of Pennsylvania in the US[L30673, L30678]. Pre-clinical studies in mice and monkeys showed evidence that the vaccine facilitates an impressive generation of neutralizing antibodies . The next phase of this study is for...
Investigational
Matched Name: … ChulaCov19 mRNA vaccine …
Matched Description: … The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration …
Matched Description: … The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration …
SARS-CoV-2 mRNA vaccine
SARS-CoV-2 mRNA vaccine (ARCoV) is a novel mRNA coronavirus vaccine that consists of a lipid nanoparticle-encapsulated mRNA encoding the receptor binding domain of SARS-CoV-2 . It is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed by Abogen Biosciences, Walvax Biotechnolgoy Co., Ltd....
Investigational
Matched Name: … SARS-CoV-2 mRNA vaccine …
Matched Description: … SARS-CoV-2 mRNA vaccine (ARCoV) is a novel mRNA coronavirus vaccine that consists of a lipid nanoparticle-encapsulated ... mRNA encoding the receptor binding domain of SARS-CoV-2[A220048]. ... It is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed …
Matched Description: … SARS-CoV-2 mRNA vaccine (ARCoV) is a novel mRNA coronavirus vaccine that consists of a lipid nanoparticle-encapsulated ... mRNA encoding the receptor binding domain of SARS-CoV-2[A220048]. ... It is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed …
LioCyx-M004
LioCyx-M004 are autologous T cells transduced with a retroviral vector encoding a hepatitis B virus antigen-specific T cell receptor.
Investigational
Matched Synonyms: … mRNA HBV/TCR T-cells …
CVnCoV
The CVnCov Vaccine (or CV07050101) is in development by CureVac AG. The vaccine uses mRNA technology to create a protein associated with SARS-CoV2, and upon administration and replication, to initiate subsequent immune responses in the body. As of June 2020, the company received regulatory approval from German and Belgian Authorities...
Investigational
Matched Synonyms: … SARS-CoV-2 mRNA vaccine …
Matched Description: … The vaccine uses mRNA technology to create a protein associated with SARS-CoV2, and upon administration …
Matched Description: … The vaccine uses mRNA technology to create a protein associated with SARS-CoV2, and upon administration …
7-methyl-guanosine-5'-triphosphate-5'-guanosine
Experimental
Matched Synonyms: … mRNA cap analog N7-Methyl GpppG …
Teprasiran
Teprasiran is under investigation in clinical trial NCT03510897 (QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery).
Investigational
Matched Synonyms: … Synthetic double-stranded siRNA oligonucleotide directed against p53 mRNA …
Fitusiran
Fitusiran is under investigation in clinical trial NCT02554773 (An Open-label Extension Study of an Investigational Drug, ALN-AT3SC, in Patients With Moderate or Severe Hemophilia A or B).
Investigational
Matched Synonyms: … Synthetic double-stranded siRNA oligonucleotide against antithrombin mRNA …
VO659
VO659 is an antisense oligonucleotide being investigated for the treatment of Huntington's disease.
Investigational
Matched Synonyms: … oligonucleotide that has been developed to target expanded CAG repeats in messenger ribonucleic acid (mRNA …
Zorevunersen
Investigational
Matched Synonyms: … 18-Mer Antisense Oligonucleotide Complementary To SCN1A mRNA …
NTLA-2002
NTLA-2002 is a lipid nanoparticle encapsulating single guide RNA (G012267) targeting the human KLKB1 gene and messenger RNA (mRNA000042) encoding Cas9. It is an investigational therapy designed to knock out the target gene kallikrein B1 (KLKB1) to reduce plasma kallikrein activity, thereby preventing hereditary angioedema attacks.
Investigational
ARCT-810
ARCT-810 is an mRNA replacement therapy that delivers ornithine transcarbamylase mRNA to hepatocytes.
Investigational
Matched Description: … ARCT-810 is an mRNA replacement therapy that delivers ornithine transcarbamylase mRNA to hepatocytes. …
GsMtx-4
GsMtx-4 is a peptide found in tarantula venom that inhibits mechanosensitive ion channel (MSC) activity.
Investigational
Matched Description: … GsMtx-4 is a peptide found in tarantula venom that inhibits mechanosensitive ion channel (MSC) activity …
UX053
UX053 is an mRNA encoding the human glycogen debranching enzyme.
Investigational
Matched Description: … UX053 is an mRNA encoding the human glycogen debranching enzyme. …
Displaying drugs 101 - 125 of 166 in total