Displaying drugs 13201 - 13225 of 13918 in total
LTI-03
LTI-03 is a caveolin-1 Scaffolding Domain 7-Mer
Investigational
Matched Description: … LTI-03 is a caveolin-1 Scaffolding Domain 7-Mer …
Mericitabine
Mericitabine has been investigated for the treatment of Hepatitis C, Chronic.
Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of PSI-6130, which demonstrated excellent potency in preclinical studies. PSI-6130 is a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase, an...
Investigational
Matched Iupac: … [(2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-fluoro-4-methyl-3-[(2-methylpropanoyl)oxy ... ]oxolan-2-yl]methyl 2-methylpropanoate …
Matched Description: … Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. ... Mericitabine is a prodrug of PSI-6130, which demonstrated excellent potency in preclinical studies. ... PSI-6130 is a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase, an enzyme that is necessary …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. ... Mericitabine is a prodrug of PSI-6130, which demonstrated excellent potency in preclinical studies. ... PSI-6130 is a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase, an enzyme that is necessary …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Vibriolysin
Vibriolysin is a proteolytic enzyme secreted by the marine microorganism Vibrio proteolyticus. It is a new agent for enzymatic debridement, shown to rapidly and thoroughly hydrolyze burn wound eschar within full-thickness wounds.
Investigational
Matched Description: … Vibriolysin is a proteolytic enzyme secreted by the marine microorganism Vibrio proteolyticus. ... It is a new agent for enzymatic debridement, shown to rapidly and thoroughly hydrolyze burn wound eschar …
Eldelumab
MDX-1100, a fully human antibody that targets IP10 (also known as CXCL10), a chemokine expressed in association with multiple inflammatory disease indications, such as rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis.
Investigational
Matched Description: … MDX-1100, a fully human antibody that targets IP10 (also known as CXCL10), a chemokine expressed in association …
Talsupram
Talsupram is a selective norepinephrine reuptake inhibitor (NRI). It was under research for the treatment of depression in 1960 and 1970 but it was never marketed. Talsupram presents a similar structure to citalopram.
Experimental
Matched Iupac: … [3-(3,3-dimethyl-1-phenyl-1,3-dihydro-2-benzothiophen-1-yl)propyl](methyl)amine …
Matched Description: … Talsupram presents a similar structure to [citalopram]. ... Talsupram is a selective norepinephrine reuptake inhibitor (NRI). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Talsupram presents a similar structure to [citalopram]. ... Talsupram is a selective norepinephrine reuptake inhibitor (NRI). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
Experimental
Matched Name: … 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine …
Matched Iupac: … 8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-(pent-4-yn-1-yl)-9H-purin-6-amine …
Matched Iupac: … 8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-(pent-4-yn-1-yl)-9H-purin-6-amine …
MLN576
XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both topoisomerase (Topo) I and II.
Investigational
Matched Iupac: … N-[(2R)-1-(dimethylamino)propan-2-yl]-1-methoxy-5,10-diazatetraphene-6-carboxamide …
Matched Description: … XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Description: … XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Loprazolam
Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence...
Experimental
Matched Iupac: … ^{2,6}]tetradeca-1(10),5,8,11,13-pentaen-3-one ... (4Z)-9-(2-chlorophenyl)-4-[(4-methylpiperazin-1-yl)methylidene]-12-nitro-2,5,8-triazatricyclo[8.4.0.0 …
Matched Description: … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. ... Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. ... Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Vafidemstat
Vafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease).
Investigational
Matched Iupac: … 5-({[(1R,2S)-2-[4-(benzyloxy)phenyl]cyclopropyl]amino}methyl)-1,3,4-oxadiazol-2-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Balhimycin
Balhimycin is a novel glycopeptide antibiotic.
Experimental
Matched Iupac: … )oxan-2-yl]oxy}-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2^{3,6}.2^{14,17}.1^{8,12}.1^{29,33 ... }.0^{10,25}.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29,31,33(45),34(39),35,37,46,49-pentadecaene-40 ... 2-[(4-amino-4,6-dimethyl-5-oxooxan-2-yl)oxy]-22-(carbamoylmethyl)-5,47-dichloro-18,32,35,37-tetrahydroxy ... -19-[4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-48-{[3,4,5-trihydroxy-6-(hydroxymethyl …
Matched Description: … Balhimycin is a novel glycopeptide antibiotic. …
Matched Description: … Balhimycin is a novel glycopeptide antibiotic. …
Marbofloxacin
Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary medicine. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon.
Vet approved
Matched Iupac: … 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1,2-diazatricyclo[7.3.1.0⁵,¹³]trideca-5(13) …
Matched Description: … Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. ... A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. ... A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Thiostrepton
Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes including Streptomyces azureus and Streptomyces laurentii. Thiostrepton is a natural product of the ribosomally synthesized and post-translationally modified peptide class.
Vet approved
Matched Iupac: … [1-(C-hydroxycarbonimidoyl)eth-1-en-1-yl]prop-2-enimidic acid ... -pentadecaazanonacyclo[23.23.9.2²⁹,³².1²,⁵.1¹²,¹⁵.1¹⁹,²².1³¹,³⁵.1⁵⁴,⁵⁷.0¹,⁵³]tetrahexaconta-2(64),4,6,9,12 ... ,21,23,29,31,33,38,41,44,47,51,54,57,60-icosaen-51-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]-N- ... 2-[({2-[(11E)-37-(butan-2-yl)-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-6,9,16,23,38,41,44,47,59-nonahydroxy ... -8,60-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-28-oxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,30,36,39,42,45,48,52,58,62,63,64 …
Matched Description: … Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes ... Thiostrepton is a natural product of the ribosomally synthesized and post-translationally modified peptide …
Matched Description: … Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes ... Thiostrepton is a natural product of the ribosomally synthesized and post-translationally modified peptide …
Collagen-polyvinylpyrrolidone
Collagen-polyvinylpyrrolidone is a copolymer generated from a mixture of type I collagen and low-molecular-weight PVP that has undergone γ irradiation . It is characterized by antifibrotic, fibrolytic, and immunomodulatory properties .
Investigational
Matched Description: … Collagen-polyvinylpyrrolidone is a copolymer generated from a mixture of type I collagen and low-molecular-weight …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Danegaptide
Danegaptide has been investigated for the treatment of Focus of Study is STEMI.
Investigational
Matched Iupac: … (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid …
JPC-3210
JPC-3210 is a potent antimalarial agent. It is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine malaria, and favourable preclinical pharmacokinetics including a lengthy plasma elimination half-life.
Experimental
Matched Iupac: … 4-tert-butyl-2-[(tert-butylamino)methyl]-6-[5-fluoro-6-(trifluoromethyl)pyridin-3-yl]phenol …
Matched Description: … JPC-3210 is a potent antimalarial agent. ... potent in vivo efficacy against murine malaria, and favourable preclinical pharmacokinetics including a …
Matched Description: … JPC-3210 is a potent antimalarial agent. ... potent in vivo efficacy against murine malaria, and favourable preclinical pharmacokinetics including a …
OTX-2002
OTX-2002 is a bicistronic messenger ribonucleic acid (mRNA) encoding for ZF-DNMT and ZF-KRAB proteins, encapsulated in a lipid nanoparticle (LNP).
Investigational
Matched Description: … , encapsulated in a lipid nanoparticle (LNP). ... OTX-2002 is a bicistronic messenger ribonucleic acid (mRNA) encoding for ZF-DNMT and ZF-KRAB proteins …
PF-07799933
PF-07799933 is a BRAF class 2 inhibitor developed by Pfizer.
Investigational
Matched Description: … PF-07799933 is a BRAF class 2 inhibitor developed by Pfizer. …
RO7200220
RO7200220 is a recombinant fully humanized anti-IL 6 monoclonal antibody.
Investigational
Matched Description: … RO7200220 is a recombinant fully humanized anti-IL 6 monoclonal antibody. …
DiaVacs
DiaVacs is a CD40/CD80/CD86 modified autologous dendritic cell therapy
Investigational
Matched Description: … DiaVacs is a CD40/CD80/CD86 modified autologous dendritic cell therapy …
Olinciguat
Olinciguat is under investigation in clinical trial NCT03892499 (A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers).
Investigational
Matched Iupac: … (2R)-3-[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-yl)amino ... ]-2-hydroxy-2-(trifluoromethyl)propanamide …
Matched Description: … Olinciguat is under investigation in clinical trial NCT03892499 (A Trial to Evaluate the Effect of Itraconazole ... (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat …
Matched Description: … Olinciguat is under investigation in clinical trial NCT03892499 (A Trial to Evaluate the Effect of Itraconazole ... (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat …
Zilovertamab vedotin
Zilovertamab vedotin is an Antibody-drug conjugate (ADC) comprising an anti-ROR1 monoclonal antibody (UC-961), a proteolytically cleavable maleimidocaproyl-valine-citrulline-para-aminobenzoate linker (mc-vc-PAB), and a monomethyl auristatin E (MMAE) cytotoxin.
Investigational
Matched Description: … proteolytically cleavable maleimidocaproyl-valine-citrulline-para-aminobenzoate linker (mc-vc-PAB), and a ... Zilovertamab vedotin is an Antibody-drug conjugate (ADC) comprising an anti-ROR1 monoclonal antibody (UC-961), a …
SIG-205
SIG-205 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral vector to express human native alpha-L-iduronidase enzyme (hIDUA), encapsulated within two-layer modified alginate spheres
Investigational
Matched Description: … SIG-205 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral …
Tenofovir exalidex
Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).
Investigational
Matched Iupac: … ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)[3-(hexadecyloxy)propoxy]phosphinic acid …
Matched Description: … Study of a Single Dose of CMX157 in Healthy Volunteers). ... Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Study of a Single Dose of CMX157 in Healthy Volunteers). ... Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Doramapimod
Doramapimod is a P38 MAP kinase inhibitor.
Investigational
Matched Iupac: … 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea …
Matched Description: … Doramapimod is a P38 MAP kinase inhibitor. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Doramapimod is a P38 MAP kinase inhibitor. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 13201 - 13225 of 13918 in total