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Displaying drugs 13251 - 13275 of 13804 in total

mRNA-3745

mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs encoding human glucose 6-phosphatase (G6Pase).
Investigational
Matched Description: … mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs …

Gallium maltolate

Gallium maltolate is Titan’s novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
Investigational
Matched Iupac: … gallium(3+) ion tris(2-methyl-4-oxo-4H-pyran-3-olate) …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

(S)-Rolipram

A phosphodiesterase inhibitor with antidepressant properties. [PubChem]
Experimental
Matched Iupac: … (4S)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one …
Matched Description: … A phosphodiesterase inhibitor with antidepressant properties. [PubChem] …

5'-Guanosine-Diphosphate-Monothiophosphate

Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.
Experimental
Matched Synonyms: … Guanosine 5'-O-(3-thiotriphosphate) …
Matched Iupac: … ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy …
Matched Description: … Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. ... A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding …

Timdarpacept

IMM01 is a recombinant human signal regulatory protein α (SIRPα) IgG 1 fusion protein. IMM01 is under investigation in clinical trial NCT05140811 (A Study of IMM01 Combined With Azacitidine in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome).
Investigational
Matched Description: … IMM01 is a recombinant human signal regulatory protein α (SIRPα) IgG 1 fusion protein. ... [A257261] IMM01 is under investigation in clinical trial NCT05140811 (A Study of IMM01 Combined With …

CGS-27023

Experimental
Matched Iupac: … (2R)-N-hydroxy-3-methyl-2-{N-[(pyridin-3-yl)methyl]4-methoxybenzenesulfonamido}butanamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ORG-25935

Org 25935 has been used in trials studying the treatment of Alcoholism, Schizophrenia, and Panic Disorder.
Investigational
Matched Iupac: … 2-({[(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl}(methyl)amino)acetic acid …

BacTRL-spike

BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to...
Investigational
Matched Description: … As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled ... engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. ... BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum …

Dihydromorphine

A semisynthetic analgesic used in the study of narcotic receptors. It has abuse potential. [PubChem]
Experimental
Illicit
Matched Description: … A semisynthetic analgesic used in the study of narcotic receptors. It has abuse potential. [PubChem] …

Cannabinor

Cannabinor, a synthetic CB2-selective agonist, is in Phase 2 clinical testing as an analgesic.
Investigational
Matched Iupac: … (2E)-4-{2-[(1S,2S,5S)-6,6-dimethyl-4-oxobicyclo[3.1.1]heptan-2-yl]-3-hydroxy-5-(2-methyloctan-2-yl)phenoxy ... }-4-oxobut-2-enoic acid …
Matched Description: … Cannabinor, a synthetic CB2-selective agonist, is in Phase 2 clinical testing as an analgesic. …

FLX475

FLX475 is a small molecule CCR4 antagonist being investigated for the treatment of cancer.
Investigational
Matched Description: … FLX475 is a small molecule CCR4 antagonist being investigated for the treatment of cancer.[L9875] …

BI-765063

BI-765063 is a humanized IgG4 monoclonal antibody antagonist of signal regulatory protein α (SIRPα).
Investigational
Matched Description: … BI-765063 is a humanized IgG4 monoclonal antibody antagonist of signal regulatory protein α (SIRPα). …

Boron

Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table. It is a low-abundant metalloid that is a poor electrical conductor at room temperature. Natural boron exists in 2 stable isotopes however pure boron is hard...
Experimental
Matched Description: … Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in ... Natural boron exists in 2 stable isotopes however pure boron is hard to prepare due to contamination ... It is a low-abundant metalloid that is a poor electrical conductor at room temperature. …

OPC-28326

At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2-adrenoceptors while having minimal action on systemic blood pressure, heart rate and coronary, carotid, vertebral, renal, and mesenteric blood flows. It is the only clinical compound with this profile. It is currently being...
Investigational
Matched Iupac: … N-(2,6-dimethyl-4-{4-[methyl(2-phenylethyl)amino]piperidine-1-carbonyl}phenyl)propanamide hydrate hydrochloride …
Matched Description: … doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

EGS21

EGS21(TM) is a beta-D-glucosylceramide (GC) compound. It is a potential therapeutic for treating immune mediated disorders. GC is a glycolipid that has been shown by Enzo scientists and collaborators to act as an anti-inflammatory agent in animal model systems, and therefore is being evaluated as an important candidate drug in...
Investigational
Matched Description: … EGS21(TM) is a beta-D-glucosylceramide (GC) compound. ... It is a potential therapeutic for treating immune mediated disorders. ... GC is a glycolipid that has been shown by Enzo scientists and collaborators to act as an anti-inflammatory …

Dimenoxadol

Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United States it is classified as a Schedule I controlled drug.
Experimental
Illicit
Matched Iupac: … 2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate …
Matched Description: … In the United States it is classified as a Schedule I controlled drug. ... It is structurally similar to methadone and is a benzilic acid derivative. …

Bempegaldesleukin

Bempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)).
Investigational
Matched Description: … Bempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination ... With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy …

Senicapoc

Senicapoc (ICA-17043) is a novel Gardos channel blocker. It is being investigated for the treatment of sickle cell disease.
Investigational
Matched Synonyms: … 2,2-Bis(4-fluorophenyl)-2-phenylacetamide …
Matched Iupac: … 2,2-bis(4-fluorophenyl)-2-phenylacetamide …
Matched Description: … Senicapoc (ICA-17043) is a novel Gardos channel blocker. …

Tribulus terrestris

Tribulus terrestris is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Description: … Tribulus terrestris is a plant/plant extract used in some OTC (over-the-counter) products. …

Deutivacaftor

Deutivacaftor is under investigation in clinical trial NCT03227471 (A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis).
Investigational
Matched Iupac: … N-{2-tert-butyl-5-hydroxy-4-[2-(2H3)methyl(1,1,1,3,3,3-2H6)propan-2-yl]phenyl}-4-oxo-1,4-dihydroquinoline ... -3-carboxamide …
Matched Description: … Deutivacaftor is under investigation in clinical trial NCT03227471 (A Study of VX-445 in Healthy Subjects …

MK-0736

MK-0736 is under investigation in clinical trial NCT00679055 (A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)).
Investigational
Matched Iupac: … 3-{4-[3-(ethanesulfonyl)propyl]bicyclo[2.2.2]octan-1-yl}-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4 …
Matched Description: … MK-0736 is under investigation in clinical trial NCT00679055 (A Study of How MK-0736 Affects Arterial …

Sepiapterin

Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia).
Investigational
Matched Iupac: … 2-amino-6-[(2S)-2-hydroxypropanoyl]-1,4,7,8-tetrahydropteridin-4-one …
Matched Description: … Sepiapterin is under investigation in clinical trial NCT03519711 (A Study of CNSA-001 in Primary Tetrahydrobiopterin …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Mibavademab

Mibavademab is under investigation in clinical trial NCT04159415 (Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy).
Investigational
Matched Description: … Mibavademab is under investigation in clinical trial NCT04159415 (Study of REGN4461, a Leptin Receptor …

Petosemtamab

Petosemtamab is under investigation in clinical trial NCT03526835 (A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors).
Investigational
Matched Description: … -158 in Patients With Advanced Solid Tumors). ... Petosemtamab is under investigation in clinical trial NCT03526835 (A Study of Bispecific Antibody MCLA …

Pegtarviliase

Pegtarviliase is under investigation in clinical trial NCT05154890 (A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency).
Investigational
Matched Description: … Pegtarviliase is under investigation in clinical trial NCT05154890 (A Multiple Ascending Dose Study of …
Displaying drugs 13251 - 13275 of 13804 in total