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Displaying drugs 13551 - 13575 of 13634 in total

Cerlapirdine

Cerlapirdine has been investigated for the treatment of Alzheimer Disease.
Investigational
Matched Iupac: … dimethyl(3-{[3-(naphthalene-1-sulfonyl)-1H-indazol-5-yl]oxy}propyl)amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …

Urelumab

Urelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer - Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. Urelumab is a fully human antibody that targets CD137. The antibody product was developed using Medarex's UltiMAb(R) technology and was the first UltiMAb- derived antibody in...
Investigational
Matched Description: … Urelumab is a fully human antibody that targets CD137. ... studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer - Solid Tumors and B-Cell …

Firocoxib

Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use...
Experimental
Vet approved
Matched Iupac: … 3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one …
Matched Description: … Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. ... Firocoxib was the first COX-2 inhibitor approved by the U.S. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …

Deracoxib

Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to increase palatability. Deramaxx received FDA approval in August 2002 for "the control of post operative pain and inflammation associated with...
Vet approved
Matched Iupac: … 4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide …
Matched Description: … Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

KB002

KB002 is an engineered human IgG1k antibody engineered human. It is developed for the treatment of autoimmune diseases, initially rheumatoid arthritis.
Investigational

Latiglutenase

Investigational

PN0621

PN0621 is an anti-TNF, domain antibody (dAb) based therapeutic. It targets tumour necrosis factor (TNF) to treat auto-immune inflammatory diseases such as rheumatoid arthritis. It is being developed by Peptech.
Investigational

Belotecan

Belotecan has been investigated for the treatment of Epithelial Ovarian Cancer.
Investigational
Matched Iupac: … }.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione ... (19S)-19-ethyl-19-hydroxy-10-{2-[(propan-2-yl)amino]ethyl}-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11 …
Matched Categories: … Topoisomerase 1 (TOP1) inhibitors …

Gaboxadol

Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in...
Investigational
Matched Synonyms: … 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol …
Matched Iupac: … 2H,3H,4H,5H,6H,7H-[1,2]oxazolo[5,4-c]pyridin-3-one …
Matched Description: … Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep ... It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Xaliproden

Investigational
Matched Iupac: … 1-[2-(naphthalen-2-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-03758309

PF-03758309 has been used in trials studying the treatment of Advanced Solid Tumors.
Investigational
Matched Iupac: … N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-({2-methylthieno[3,2-d]pyrimidin-4-yl}amino)- …
Matched Salts cas: … 1279034-84-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Radafaxine

Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.
Investigational
Matched Iupac: … (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol …

Reglitazar

Reglitazar, an isoxazolidine-3,5-dione derivative, is being developed by Pfizer for the treatment of diabetes. It is the first non-thiazolidenedione to enter clinical trials.
Investigational
Matched Iupac: … 4-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}methyl)-1,2-oxazolidine-3,5-dione …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Dilmapimod

Dilmapimod has been used in trials studying the treatment and diagnostic of Nerve Trauma, Inflammation, Pain, Neuropathic, Arthritis, Rheumatoid, and Coronary Heart Disease, among others. Dilmapimod (SB-681323) is a p38 MAP-kinase inhibitor that has potential uses in inflammatory conditions such as RA (Rheumatoid Arthritis). Previous p38 MAP-kinase inhibitors have been...
Investigational
Matched Iupac: … 8-(2,6-difluorophenyl)-2-[(1,3-dihydroxypropan-2-yl)amino]-4-(4-fluoro-2-methylphenyl)-7H,8H-pyrido[2,3 …
Matched Description: … Dilmapimod (SB-681323) is a p38 MAP-kinase inhibitor that has potential uses in inflammatory conditions …
Matched Salts cas: … 937169-00-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Banoxantrone

Banoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic to, hypoxic cells in tumours. It has been shown to work synergistically with fractionated radiation to significantly delay growth of tumours compared to administration of either banoxantrone or radiation alone. Banoxantrone was also efficacious in...
Investigational
Matched Iupac: … 2-[(4-{[2-(dimethyl-oxo-$l^{5}-azanyl)ethyl]amino}-5,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl ... )amino]-N,N-dimethylethanamine oxide …
Matched Description: … Banoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic …

CVnCoV Vaccine

The CVnCov Vaccine (or CV07050101) is in development by CureVac AG. The vaccine uses mRNA technology to create a protein associated with SARS-CoV2, and upon administration and replication, to initiate subsequent immune responses in the body. As of June 2020, the company received regulatory approval from German and Belgian Authorities...
Investigational
Matched Description: … The vaccine uses mRNA technology to create a protein associated with SARS-CoV2, and upon administration ... 2020, the company received regulatory approval from German and Belgian Authorities to commence Phase 1 …

DG031

DG031, deCODE genetics's lead compound, is being developed for the prevention of myocardial infarction, or heart attack.
Investigational

Balapiravir

Balapiravir has been used in trials studying the treatment of Dengue and Hepatitis C, Chronic.
Investigational
Matched Iupac: … [(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-2-azido-3,4-bis[(2-methylpropanoyl)oxy]oxolan ... -2-yl]methyl 2-methylpropanoate …

Fradafiban

Investigational
Matched Iupac: … 2-[(3S,5S)-5-[({4'-carbamimidoyl-[1,1'-biphenyl]-4-yl}oxy)methyl]-2-oxopyrrolidin-3-yl]acetic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Cobaltous sulfate

Experimental
Matched Iupac: … lambda2-cobalt(2+) sulfate …
Matched Salts cas: … 10026-24-1 …

Foretinib

Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally available small molecule compound designed to target multiple RTKs implicated in the development, progression and spread of cancer. It inhibits...
Investigational
Matched Iupac: … N'1-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N1-(4-fluorophenyl …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Epetraborole

Epetraborole has been used in trials studying the treatment of Infections, Bacterial, Infections, Intestinal, Infections, Urinary Tract, and Community-acquired Infection.
Investigational
Matched Iupac: … (3S)-3-(aminomethyl)-7-(3-hydroxypropoxy)-1,3-dihydro-2,1-benzoxaborol-1-ol …
Matched Salts cas: … 1234563-16-6 …

Pevonedistat

Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others.
Investigational
Matched Iupac: … [(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pilaralisib

Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Glioblastoma, and Breast Cancer, among others.
Investigational
Matched Iupac: … 2-amino-N-[3-({3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}sulfamoyl)phenyl]-2-methylpropanamide …
Matched Description: … Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Phosphatidylinositol 3-Kinases, antagonists & inhibitors …

Indisulam

Investigational
Matched Iupac: … N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide …
Displaying drugs 13551 - 13575 of 13634 in total