Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 1426 - 1450 of 1870 in total

Vedolizumab

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease. α4β7 integrin facilitates the interaction between lymphocytes and gut endothelial cells through the α4β7 integrin-MAdCAM1 interaction, leading to the mobilization...
Approved
Matched Description: … for the maintenance therapy of moderately to severely active Ulcerative Colitis and Crohn’s Disease in ... April and September 2023, respectively. ... six weeks and then every 8 weeks thereafter. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Entyvio 300mg Powder for Concentrate for Solution for Infusion ... ENTYVIO POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 300MG/VIAL …

Bendamustine

Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine...
Approved
Investigational
Matched Description: … a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and ... Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks ... It is active against both active and quiescent cells, although the exact mechanism of action is unknown …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/VIAL USP ... BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/VIAL USP ... RIBOMUSTIN 25MG/VIAL POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION …

Bevacizumab

There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … the survival and proliferation of cancer cells. ... [A193272,A193275] It is a humanized monoclonal IgG antibody, and inhibits angiogenesis by binding and ... [A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Experimental Unapproved Treatments for COVID-19 …
Matched Products: … MVASI Concentrate for Solution for Infusion 25 mg/ml ... ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 ML ... MVASI CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML …

Pertuzumab

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in...
Approved
Matched Description: … It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal ... It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. ... Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... pertuzumab and trastuzumab ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Perjeta 420 mg concentrate for solution for infusion ... PERJETA CONCENTRATE FOR SOLUTION FOR INFUSION 420MG/14ML ... PHESGO SOLUTION FOR SUBCUTANEOUS INJECTION 600 MG/600 MG / 10 ML …

(3-Formyl-but-3-Enyl)-Phosphonic Acid

Experimental
Matched Name: … (3-Formyl-but-3-Enyl)-Phosphonic Acid …

5-Formyl-2'-deoxy-cytidine-5'-monophosphate

Experimental
Matched Name: … 5-Formyl-2'-deoxy-cytidine-5'-monophosphate …
Matched Iupac: … {[(2R,3S,5R)-5-(4-amino-5-formyl-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic …

Azacitidine

Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it...
Approved
Investigational
Matched Description: … As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and ... inhibiting protein and DNA synthesis. ... [A1407] Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … VIDAZA POWDER FOR SUSPENSION FOR INJECTION 100 MG /VIAL ... Azacitidine For ... Vidaza powder for suspension for injection 100mg/vial …

Erenumab

Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and ... first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … AIMOVIG (140 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG (70 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED PEN 70MG/ML …

Buprenorphine

Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Description: … patients with severe pain and reducing the reinforcing effects of opioids which can lead to drug-seeking ... [A186286] For example, buprenorphine dissociates from opioid receptors very slowly, resulting in a long ... duration of action and relief from pain or withdrawal symptoms for upwards of 24-36 hours. …
Matched Mixtures name: … Buprenorphine HCl and Naloxone HCl ... Buprenorphine and Naloxone ... Buprenorphine and Naloxone …
Matched Products: … Bar-buprenorphine ... TEMGESIC FORTE SUBLI 0.4MG …

Irinotecan

Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of camptothecin, which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility. As an anticancer drug, irinotecan was first commercially available in Japan in 1994...
Approved
Investigational
Matched Description: … This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death.[A263376] ... Irinotecan is a topoisomerase inhibitor used for chemotherapy. ... Both irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … IRITEC CONCENTRATE FOR SOLUTION FOR INFUSION 40mg/2ml ... IRITEC CONCENTRATE FOR SOLUTION FOR INFUSION 100mg/5ml ... Irinotesin Concentrate for Solution for Infusion 20mg/ ml …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … the treatment of retinopathy of prematurity in preterm infants in February 2023 and for the treatment ... and February 2013, respectively. ... the treatment of metastatic colorectal cancer, and it was approved by the FDA and EMA in August 2012 …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Zaltrap 25mg/ml Concentrate for Solution for Infusion ... ZALTRAP CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML ... EYLEA SOLUTION FOR INJECTION IN VIAL 2MG …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing ... [L7489] In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for ... [A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Tecentriq 60mg/ml Concentrate for Solution for Infusion ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 840MG/14ML ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 1200 MG/ 20 ML …

Alglucosidase alfa

Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell...
Approved
Matched Description: … It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients. ... Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages ... residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … Myozyme Powder for Solution for Injection ... (Alglucosidase alfa) 50mg Powder for Solution for Infusion …

Prednisolone

Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955.
Approved
Vet approved
Matched Description: … , anti-neoplastic, and vasoconstrictive effects. ... Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive …
Matched Mixtures name: … Delta - Hädensa - Salbe …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Corticosteroids for Systemic Use ... Corticosteroids for Systemic Use, Plain ... Corticosteroids for Local Oral Treatment ... Alimentary Tract and Metabolism …
Matched Products: … Kühlprednon - Salbe ... NORSOL % 1 FORTE GÖZ KULAK DAMLASI, ÇÖZELTİ, 5 ML …

Mepolizumab

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically ... Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote ... Mepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs for Obstructive Airway Diseases …
Matched Products: … Nucala 100mg Powder for Solution for Injection ... NUCALA POWDER FOR SOLUTION FOR INJECTION 100mg ... NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML …

APTO-253

Investigational
Matched Synonyms: … Lt-253(former code) ... Lor-253(former code) …

Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … HYCAMTIN (POWDER FOR SOLUTION FOR INFUSION) ... TOCANTIN POWDER FOR SOLUTION FOR INFUSION 4MG ... TOCANTIN POWDER FOR SOLUTION FOR INFUSION 4 MG/VIAL …

Adalimumab

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered ... arthritis and other chronic debilitating diseases mediated by tumor necrosis factor. ... [A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … IDACIO solution for Injection for paediatric use 40mg/0.8ml ... IDACIO SOLUTION FOR INJECTION FOR PAEDIATRIC USE 40MG/0.8ML VIAL ... HUMIRA SOLUTION FOR INJECTION …

Zoledronic acid

Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid...
Approved
Matched Description: … [A203111] Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia ... third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and ... of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. …
Matched Categories: … zoledronic acid, calcium and colecalciferol, sequential ... Drugs Affecting Bone Structure and Mineralization ... Drugs for Treatment of Bone Diseases …
Matched Products: … ZOVA CONCENTRATE FOR SOLUTION FOR INFUSION 4MG/5ML ... ZOLETEM CONCENTRATE FOR SOLUTION FOR INFUSION 4MG/5ML ... ZOBONE CONCENTRATE FOR SOLUTION FOR INFUSION 4MG/5ML …

Alirocumab

Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and ... Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hypolipidemic Agents Indicated for Hyperlipidemia ... Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia …
Matched Products: … Praluent 75 mg solution for injection in pre-filled syringe ... Praluent 150 mg solution for injection in pre-filled syringe ... Praluent 75 mg solution for injection in pre-filled pen …

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … Golimumab binds and inhibits soluble and transmembrane human TNFα. ... Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients ... with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … SIMPONI IV 12.5mg/1ml Concentrate for Solution for Infusion ... Concentrate for Solution for Infusion 12.5mg/1 ml ... SIMPONI SOLUTION FOR INJECTION …

Sarilumab

Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed...
Approved
Investigational
Matched Description: … soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL ... in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid ... human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG ... KEVZARA Solution for Injection in Pre-filled Pen 150mg ... KEVZARA Solution for Injection in Pre-filled Pen 200mg …

Styphnolobium japonicum flower bud

Styphnolobium japonicum flower bud is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Products: … BARAMO for O ily Scalp ... BARAMO for Normal Scalp ... BARAMO Scalp Serum for Normal Scalp …

Glycyl-L-a-Aminopimelyl-E-(D-2-Aminoethyl)Phosphonate

Experimental
Matched Name: … Glycyl-L-a-Aminopimelyl-E-(D-2-Aminoethyl)Phosphonate …

Paclitaxel

Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as...
Approved
Vet approved
Matched Synonyms: … Paclitaxel protein-bound particles for injection suspension …
Matched Description: … It is available as an intravenous solution for injection and the newer formulation contains albumin-bound ... 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel ... Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... paclitaxel and encequidar …
Matched Products: … PACLITAXEL SALUS ... Aclipak Concentrate for Solution for Infusion 6mg/ ml ... FONKOPAC CONCENTRATE FOR SOLUTION FOR INFUSION 6MG/ML …
Displaying drugs 1426 - 1450 of 1870 in total