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Displaying drugs 1626 - 1650 of 1990 in total

Tengonermin

Tengonermin, also known as NGR-hTNF, is a vascular-targeting drug. It is a recombinant protein and peptide-targeted agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. This drug works by modifying the tumor microenvironment and increasing intratumoral chemotherapy penetration and T-cell infiltration. NGR-hTNF specifically targets angiogenic...
Investigational
Matched Description: … [A233265] It is a recombinant protein and peptide-targeted agent consisting of the human Tumour Necrosis ... penetration and T-cell infiltration. ... [L33050] This drug works by modifying the tumor microenvironment and increasing intratumoral chemotherapy …
Matched Categories: … Recombinant Proteins ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

MVA-BN-brachyury-TRICOM vaccine

MVA-BN-brachyury-TRICOM vaccine is an investigational cancer vaccine. It is composed of recombinant vaccinia viral vector, modified vaccinia Ankara-Bavarian Nordic (MVA-BN), encoding the human transcription factor and tumour-associated antigen (TAA) brachyury, and a triad of T-cell co-stimulatory molecules (TRICOM), which is comprised of the three human immune-enhancing co-stimulatory molecules B7-1, ICAM-1...
Investigational
Matched Description: … ), encoding the human transcription factor and tumour-associated antigen (TAA) brachyury, and a triad ... It is composed of recombinant vaccinia viral vector, modified vaccinia Ankara-Bavarian Nordic (MVA-BN ... of T-cell co-stimulatory molecules (TRICOM), which is comprised of the three human immune-enhancing …

Leronlimab

Leronlimab, or PRO-140, is a human monoclonal antibody developed by CytoDyn. It was first described in the literature in 2001. This antibody binds to CCR5, which may be useful in treating HIV, cancers, and severely ill COVID-19 patients.[A192846,A192858,L12684]
Investigational
Matched Description: … Leronlimab, or PRO-140, is a human monoclonal antibody developed by CytoDyn. ... [A3922] This antibody binds to CCR5, which may be useful in treating HIV, cancers, and severely ill COVID …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Chromic citrate

Experimental

KB002

KB002 is an engineered human IgG1k antibody engineered human. It is developed for the treatment of autoimmune diseases, initially rheumatoid arthritis.
Investigational
Matched Description: … KB002 is an engineered human IgG1k antibody engineered human. …

MM-093

MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and ... been associated with remission of many autoimmune diseases, including rheumatoid arthritis, psoriasis and …

OAV201

OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of a segment of the murine MECP2 promoter. It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation in clinical...
Investigational
Matched Description: … OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human ... It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation …

OBI-999

Investigational

Silibinin

Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar...
Experimental
Investigational
Matched Description: … , human colon cancer cells, and both small and nonsmall human lung carcinoma cells. ... , estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells ... Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …

Nafamostat

Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing...
Investigational
Matched Description: … It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome …

Peldesine

Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections.
Investigational
Matched Description: … Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. ... It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. …

Leukotriene C4

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle. (From Dictionary of Prostaglandins and...
Experimental
Investigational
Matched Description: … It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized ... It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular ... The conjugation product of LEUKOTRIENE A4 and glutathione. …

Glembatumumab vedotin

A conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer.
Investigational
Matched Description: … for the treatment of melanoma and breast cancer. ... A conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Humanized monoclonal antibody Hu1B7

Investigational

Cholesterol sulfate

Component of human seminal plasma & spermatozoa.
Experimental
Matched Description: … Component of human seminal plasma & spermatozoa. …

Grapiprant

Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists. This type of molecules is currently in development for veterinary patients. This class...
Investigational
Vet approved
Matched Description: … Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. ... These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic …

AGRO100

AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear in all cells, but uniquely expressed on the surface of tumor cells. Such binding leads to internalization of the complex, and a strong anti-proliferative response in the tumor cell. Pre-clinical testing demonstrates that...
Investigational
Matched Description: … colon cancer, as well as malignant melanoma and leukemia. ... Such binding leads to internalization of the complex, and a strong anti-proliferative response in the ... AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Filanesib

Filanesib is a potent Kinesin Spindle Protein (KSP) inhibitor that caused marked tumor regression in preclinical models of human solid tumors and human leukemias, often leading to durable responses.
Investigational
Matched Description: … solid tumors and human leukemias, often leading to durable responses. ... Kinesin Spindle Protein (KSP) inhibitor that caused marked tumor regression in preclinical models of human …

MVR-T3011

MVR-T3011 is a genetically modified oncolytic Herpes Simplex Virus (HSV-1) with 2 exogenous genes encoding the active heterodimer human interleukin 12 (IL-12) and the Fab fragment of an anti-human PD-1 antibody.
Investigational
Matched Description: … interleukin 12 (IL-12) and the Fab fragment of an anti-human PD-1 antibody. ... modified oncolytic Herpes Simplex Virus (HSV-1) with 2 exogenous genes encoding the active heterodimer human …

SIG-001

SIG-001 is a cultured human retinal pigment epithelial cell line (ARPE-19) genetically modified with a non-viral vector to express B domain deleted human factor VIII protein, encapsulated within two-layer modified alginate spheres.
Investigational
Matched Description: … SIG-001 is a cultured human retinal pigment epithelial cell line (ARPE-19) genetically modified with ... a non-viral vector to express B domain deleted human factor VIII protein, encapsulated within two-layer …

Quercetin

Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
Experimental
Investigational
Matched Description: … Glycosylated forms include RUTIN and quercetrin. …

MT-0169

MT-0169 is a usion protein comprised of an enzymatically active Shiga-like toxin-I A1 subunit fused to a human single chain variable fragment with affinity for human CD38 cell surface protein.
Investigational
Matched Description: … single chain variable fragment with affinity for human CD38 cell surface protein. ... 0169 is a usion protein comprised of an enzymatically active Shiga-like toxin-I A1 subunit fused to a human …

SIG-207

SIG-207 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral vector to express Human alpha-galactosidase A (alpha-Gal A), encapsulated within two-layer modified alginate spheres
Investigational
Matched Description: … vector to express Human alpha-galactosidase A (alpha-Gal A), encapsulated within two-layer modified ... SIG-207 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral …

Inodiftagene vixteplasmid

Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein coding gene).
Investigational
Matched Description: … encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human …

UX053

UX053 is an mRNA encoding the human glycogen debranching enzyme.
Investigational
Matched Description: … UX053 is an mRNA encoding the human glycogen debranching enzyme. …
Displaying drugs 1626 - 1650 of 1990 in total