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Displaying drugs 151 - 175 of 15869 in total
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including...
Approved
Matched Synonyms: … 3-((4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)(4-METHYLPHENYL)AMINO)PHENOL …
Matched Iupac: … 3-{[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino}phenol …
Matched Description: … to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and ... [L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and ... norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive...
Approved
Investigational
Matched Synonyms: … N-(3-methylaminopropyl)iminobibenzyl …
Matched Iupac: … (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine …
Matched Description: … as amitriptyline and clomipramine. ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. …
Matched Categories: … Heterocyclic Compounds, 3-Ring ... Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Flutemetamol (18F) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18. It is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.
Approved
Investigational
Matched Synonyms: … 2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol …
Matched Iupac: … 2-[3-(¹⁸F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol …
Matched Categories: … Indicators and Reagents …
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Synonyms: … 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine ... 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine ... L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine …
Matched Iupac: … (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid …
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Approved
Illicit
Matched Synonyms: … 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate …
Matched Categories: … Testosterone and derivatives …
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Synonyms: … methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate ... [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester …
Matched Iupac: … methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate …
Matched Description: … the eye, ear, nose, and throat. ... It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in ... It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse …
Matched Categories: … Analgesics and Anesthetics …
Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections. Clavulanic acid is derived from the organism Streptomyces clavuligerus. When it is combined with amoxicillin, clavulanic acid is...
Approved
Vet approved
Matched Synonyms: … (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid …
Matched Iupac: … (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Mixtures name: … Amoxicillin and clavulanate potassium ... Amoxicillin and clavulanate potassium ... Amoxicillin and clavulanate potassium …
Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid …
Matched Iupac: … 1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid …
Matched Description: … Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate.[A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597]. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is...
Approved
Investigational
Matched Synonyms: … (1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7 …
Matched Iupac: … (1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy ... -2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-dimethoxy …
Matched Description: … [A243416,A253592] Cisatracurium is an R-cis-R-cis isomer of [atracurium] and has approximately 3 times ... [A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly …
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Synonyms: … 3-fluoro-4-phenylhydratropic acid …
Matched Description: … Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. ... Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and ... formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg …
Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Synonyms: … -1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3- …
Matched Iupac: … 7aS)-octahydropyrrolo[3,4-b]morpholin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3- …
Matched Description: … the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and ... Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December …
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Synonyms: … (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl …
Matched Description: … suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and
Matched Salts cas: … 75438-58-3
Matched Categories: … moxonidine and diuretics …
Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). It is prepared from pools of healthy human donors' plasma via anion-exchange column chromatography and was approved in 2012 under the name VariZIG to reduce the...
Approved
Matched Synonyms: … Human herpesvirus 3 immune globulin …
Matched Description: … It is prepared from pools of healthy human donors' plasma via anion-exchange column chromatography and ... VariZIG to reduce the disease severity in high-risk patients who lack evidence of immunity to varicella and
Matched Categories: … Fluids and Secretions ... Amino Acids, Peptides, and Proteins …
Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Synonyms: … -(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3- …
Matched Iupac: … N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-butylphenyl)-5-{4-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3- ... methylbutanoyl]pyrrolidine-2-amido]phenyl}pyrrolidin-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl- …
Matched Description: … FDA- and Health Canada-approved product Technivie. ... categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... Ombitasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly [FDA …
Matched Categories: … Amino Acids, Peptides, and Proteins ... ombitasvir, paritaprevir and ritonavir ... dasabuvir, ombitasvir, paritaprevir and ritonavir …
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Synonyms: … )-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3- ... TRIMETHYL-1,4,7,11,14-PENTAOXO-1H-PYRROLO(2,1-I)(1,4,7,10,13)OXATETRAAZACYCLOHEXADECIN-10-YL)-4,6-DIMETHYL-3- ... N,N'-((2-AMINO-4,6-DIMETHYL-3-OXO-3H-PHENOXAZINE-1,9-DIYL)-BIS(CARBONYLIMINO(2-HYDROXYPROPYLIDENE)CARBONYLIMINOISOBUTYLIDENECARBONYL …
Matched Iupac: … )-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3- …
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Heterocyclic Compounds, 3-Ring ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Approved
Matched Synonyms: … adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate] …
Matched Description: … ., D-amino acid oxidase and L-amino acid oxidase. ... A condensation product of riboflavin and adenosine diphosphate. …
Matched Categories: … Heterocyclic Compounds, 3-Ring ... Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic...
Approved
Investigational
Matched Synonyms: … (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol …
Matched Iupac: … (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol …
Matched Description: … It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. ... Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Iupac: … (4-chlorophenyl)-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido ... ]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]pentanamido]-4-methylpentanamide ... carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-5-(carbamoylamino)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3- …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … CETROTIDE 3 MG. ... Cetrotide 0.25 mg powder and solvent for solution for injection ... CETROTIDE 3 MG ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADET …
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Synonyms: … 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine ... 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine …
Matched Description: … It inhibits gastric acid secretion, as well as pepsin and gastrins output. …
Matched Categories: … Alimentary Tract and Metabolism ... Metabolic Side Effects of Drugs and Substances ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Matched Products: … Up and Up Acid Reducer …
Approved
Investigational
Matched Synonyms: … Autologous dendritic cells pulsed with recombinant human fusion protein (MUCIN1 and Glutathione S Transferase …
Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Approved
Investigational
Matched Synonyms: … 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt …
Matched Iupac: … (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate …
Matched Description: … Constituent of striated muscle and liver. ... It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism …
Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Synonyms: … 4-{(E)-2-[6-(2-{2-[2-(18F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl}-N-methylaniline …
Matched Iupac: … 4-[(E)-2-[6-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline …
Matched Description: … density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and
Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading...
Approved
Matched Synonyms: … 3-Hydroxy-alpha-methyl-L-tyrosine …
Matched Iupac: … (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid …
Matched Description: … Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. ... [A231784] It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug ... [A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. …
Matched Mixtures name: … Methyldopa and Hydrochlorothiazide ... Methyldopa and Hydrochlorothiazide ... Methyldopa and Hydrochlorothiazide …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild,...
Approved
Vet approved
Withdrawn
Matched Synonyms: … (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid …
Matched Description: … nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. ... generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Synonyms: … 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine …
Matched Iupac: … methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine …
Matched Description: … and other conditions. ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Salts cas: … 894-71-3
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Displaying drugs 151 - 175 of 15869 in total