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Displaying drugs 1926 - 1950 of 15447 in total

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Fulvestrant

Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. While it is used as monotherapy for the...
Approved
Investigational
Matched Description: … It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Atazanavir

Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day)...
Approved
Investigational
Matched Iupac: … (2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4-phenylbutyl]-N'-{[4-(pyridin …
Matched Description: … Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. ... has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances ... distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day) and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... atazanavir and ritonavir ... atazanavir and cobicistat …

Methylnaltrexone

Methylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008.
Approved
Matched Categories: … Alimentary Tract and Metabolism …

Loteprednol

Approved
Experimental
Matched Categories: … loteprednol and antiinfectives …

Cetyl alcohol

Cetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. It can be produced from the reduction of palmitic acid. Cetyl alcohol is present in a waxy white powder or flake form at room temperature, and is insoluble in water and...
Approved
Matched Description: … It can be produced from the reduction of palmitic acid. ... According to the FDA Code of Federal Regulations, cetyl alcohol is a safe synthetic fatty acid in food ... water and soluble in alcohols and oils [A32209]. …

Luteinizing hormone

Approved
Matched Mixtures name: … MENOGON 75 IU Powder and Solvent for solution for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Azathioprine

Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of...
Approved
Matched Description: … Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and ... A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Fludarabine

Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Approved
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Triflusal

Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative. The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production of nitric oxide and the increase of cyclic nucleotide concentration on endothelial cells. The latest translates...
Approved
Investigational
Matched Iupac: … 2-(acetyloxy)-4-(trifluoromethyl)benzoic acid …
Matched Description: … Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule ... Uriach and Company and even though it is commercialized in different countries it is not approved by ... The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production …
Matched Categories: … Blood and Blood Forming Organs …

Pancrelipase

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010. For further information on the components of this mixture...
Approved
Investigational
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and ... [L2510] For further information on the components of this mixture please visit [DB11065], [DB11066] and ... [L2509] The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved …
Matched Mixtures name: … Pancreatin and Enzyme Formula - Tablet …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Liraglutide

Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid...
Approved
Matched Description: … Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as ... [A6932] Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin degludec and liraglutide ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Ciprofibrate

Approved
Investigational
Matched Iupac: … 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid …

Lacidipine

Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia . It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce...
Approved
Investigational
Matched Description: … vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and ... displays a high membrane partition coefficient leading to accumulation of the drug in the membrane and ... other long-acting dihydropyridine calcium antagonists, thiazide diuretics, atenolol (a beta-blocker) and …
Matched Categories: … Calcium-Regulating Hormones and Agents …

Tromantadine

Tromantadine is marketed as Viru-Merz in the Czech Republic . It is an antiviral used in the treatment of herpes zoster and simplex.
Approved
Matched Description: … It is an antiviral used in the treatment of herpes zoster and simplex. …

Dacarbazine

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Inotersen

Inotersen is a transthyretin-directed antisense oligonucleotide for the treatment of the polyneuropathy caused by hereditary transthyretin-mediated amyloidosis in adults. It was FDA approved in October 2018. Inotersen has been shown to improve the course of neurologic disease and quality of life in patients with hereditary transthyretin amyloidosis . Hereditary transthyretin...
Approved
Investigational
Matched Description: … Progressive amyloid accumulation may lead to multiorgan dysfunction and death [A39493]. ... [L11761] Inotersen has been shown to improve the course of neurologic disease and quality of life in ... single-nucleotide variants in the gene encoding transthyretin (TTR), which lead to transthyretin misfolding and …
Matched Categories: … Nucleic Acid Probes ... Nucleic Acids, Nucleotides, and Nucleosides …

Vanillyl butyl ether

Vanillyl butyl ether is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent.
Approved
Matched Description: … Vanillyl butyl ether is an ether of monohydroxybenzoic acid. ... , hair conditioning agent, and warming or cooling agent. ... It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent …

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Approved
Investigational
Matched Description: … A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... stavudine and lamivudine ... stavudine, lamivudine and nevirapine ... Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …

Borage oil

Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine...
Approved
Investigational
Matched Description: … Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from ... GLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) ... clinical efficacy and long-term effects are not fully elucidated yet. …

Pertuzumab

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in...
Approved
Matched Description: … It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. ... It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal ... Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant …
Matched Categories: … Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Cytarabine

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale,...
Approved
Investigational
Matched Description: … It also has antiviral and immunosuppressant properties. …
Matched Salts name: … Cytarabine hydrochloride …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... cytarabine and daunorubicin ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Patisiran

Parisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis . It is marketed as Onpattro which is formulated as patisiran within a liposome envelope for better delivery to the liver, where transthyretin is produced. The approval for Onpattro...
Approved
Investigational
Matched Description: … Onpattro has been granted Fast Track, Priority Review and Breakthrough Therapy, and Orphan Drug designations …
Matched Categories: … Nucleic Acid Probes ... Nucleic Acids, Nucleotides, and Nucleosides …

Urea

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Approved
Investigational
Matched Description: … It is the principal end product of protein catabolism and constitutes about one half of the total urinary …
Matched Mixtures name: … Lactic Acid 10% / Urea 40% ... Urea 39.5% with 2% Salicylic Acid ... Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% …
Matched Categories: … Blood and Blood Forming Organs ... Emollients and Protectives ... Blood Substitutes and Perfusion Solutions …

Festuca pratensis pollen

Festuca pratensis pollen is the pollen of the Festuca pratensis plant. Festuca pratensis pollen is mainly used in allergenic testing.
Approved
Matched Mixtures name: … Mixture of Twenty-Two Standardized and Non-Standardized Grasses …
Displaying drugs 1926 - 1950 of 15447 in total