Displaying drugs 176 - 200 of 806 in total
Norgestimate
Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with ethinylestradiol as a combined oral contraceptive that can also be used to treat moderate acne...
Approved
Investigational
Testosterone undecanoate
Testosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. There are oral and intramuscular formulations available for testosterone undecanoate: both formulations are indicated for...
Approved
Investigational
Matched Description: … [L35970,L8932,L41355]
Testosterone is a critical male hormone that is responsible for the normal …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Clomifene
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists …
Estradiol benzoate
Estradiol Benzoate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … Estradiol Benzoate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Drospirenone
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists …
Mestranol
The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Estradiol acetate
Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes ... Estradiol acetate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone …
Estradiol cypionate
Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes ... Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Estradiol valerate
Estradiol Valerate (also known as E2V) is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore...
Approved
Investigational
Vet approved
Matched Description: … The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes ... Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Leuprolide
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to...
Approved
Investigational
Matched Description: … Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). ... capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone …
Matched Categories: … Pituitary Hormone-Releasing Hormones ... Gonadotropin-releasing hormone agonist ... Gonadotropin Releasing Hormone Receptor Agonist ... Gonadotropin Releasing Hormone Receptor Agonists …
Matched Categories: … Pituitary Hormone-Releasing Hormones ... Gonadotropin-releasing hormone agonist ... Gonadotropin Releasing Hormone Receptor Agonist ... Gonadotropin Releasing Hormone Receptor Agonists …
Fezolinetant
Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopausal issues.[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms...
Approved
Investigational
Matched Description: … concerns, such as an increased risk of stroke and venous thromboembolism or hormone-dependent cancer ... [A259591,A259542]
Although hormone therapy is available for menopausal women, safety and tolerability ... hypothalamus, and has been shown to be involved as a negative regulator in generating Gonadotropin-releasing hormone …
Gestrinone
Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and is used primarily in the treatment of endometriosis.
Gestrinone was developed in the early 1970s and was tested clinically as...
Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Lutropin alfa
Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein made up of monomeric units. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in...
Approved
Matched Description: … Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 ... Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for …
Amiloxate
Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m . It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity .
Approved
Resmetirom
Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... regulate lipid metabolism in the liver; thus, impaired thyroid function, such as low serum thyroid hormone …
Matched Categories: … Thyroid hormone receptor-beta (THR-beta) agonist …
Matched Categories: … Thyroid hormone receptor-beta (THR-beta) agonist …
Liotrix
Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion....
Approved
Matched Description: … Liotrix is a synthetically derived thyroid hormone replacement preparation. ... levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Setmelanotide
Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies. It is an agonist of the melanocortin 4 receptor. Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. Other...
Approved
Investigational
Matched Categories: … Melanocyte-Stimulating Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Macimorelin
Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … Growth hormone (GH) is classically linked with linear growth during childhood. ... More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an ... In deficiency of this hormone, AGHD is commonly associated with increased fat mass (particularly in the …
Matched Categories: … Growth Hormone Secretagogue Receptor Agonist ... Growth Hormone Secretagogue Receptor Agonists …
Matched Categories: … Growth Hormone Secretagogue Receptor Agonist ... Growth Hormone Secretagogue Receptor Agonists …
Drostanolone propionate
Approved
Illicit
Octreotide
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … , somatostatin, which inhibits the secretion of growth hormone. ... Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues ... [L14501] In most cases, it results from an anterior pituitary growth hormone-releasing tumor. …
Gliquidone
Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Approved
Investigational
Methoxy polyethylene glycol-epoetin beta
Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.
Approved
Matched Description: … Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent …
Matched Categories: … Colony-Stimulating Factors ... Erythropoiesis-Stimulating Agents …
Matched Categories: … Colony-Stimulating Factors ... Erythropoiesis-Stimulating Agents …
Bromocriptine
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. Bromocriptine has been...
Approved
Investigational
Withdrawn
Matched Description: … associated with pulmonary fibrosis, and can also cause sustained suppression of somatotropin (growth hormone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists …
Alfacalcidol
Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of vitamin D. It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological...
Approved
Nutraceutical
Displaying drugs 176 - 200 of 806 in total