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Displaying drugs 1976 - 1990 of 1990 in total

INO-4800

INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. Early in vitro studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.[A214475, A214478] Follow up studies in both...
Investigational
Matched Description: … 293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human ... of INO-4800 to induce both humoral and T cell-mediated immunity against SARS-CoV-2, including in the ... [A214475, A214478] Follow up studies in both BALB/c mice and Hartley guinea pigs demonstrated the ability …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tea tree oil

Tea tree oil is an essential oil derived mainly from the Australian native plant Melaleuca alternifolia via steam distillation of the of the leaves and terminal branches . It may be referred to as Melaleuca alternifolia oil. It has been a popular ingredient in a variety of household and cosmetic...
Experimental
Nutraceutical
Matched Description: … , anti-inflammatory, broad-spectrum antimicrobial and antioxidant properties [A32438]. ... from the Australian native plant _Melaleuca alternifolia_ via steam distillation of the of the leaves and ... It has been a popular ingredient in a variety of household and cosmetic products due to its antiseptic …
Matched Mixtures name: … Muscle and Joint Heat Cream ... Bee Venom Wart And Tags Removal Treatment …

UB-612

The UB-612 COVID-19 vaccine was developed by United Biomedical Inc Asia in Taipei as the first COVID-19 “multi-tope” protein-peptide vaccine made up of eight rationally designed components . The vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human IgG1, which facilitates cell...
Investigational
Matched Description: … vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human ... It was able to reduce viral load and prevent COVID-19 infection in a mouse challenge model and in rhesus ... IgG1, which facilitates cell attachment and acts as the principal neutralizing domain of the virus[L30658 …

Gantenerumab

Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, with classical histopathological hallmarks including extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs). As the classical view of AD pathology posits that Aβ accumulation triggers tau hyperphosphorylation and aggregation to form NFTs and cause neurodegeneration, large...
Investigational
Matched Description: … [A244705, A244710, A244745] Gantenerumab is a fully human IgG1κ monoclonal antibody derived from the ... Aβ oligomers and fibrils over monomers. ... to reduce Aβ aggregation and remove Aβ plaques. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

NKG2D-ACE2 CAR-NK Cell

These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling...
Investigational
Matched Description: … First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being ... The transmembrane NKG2D and intracellular 2B4 domains are required for optimal NK signalling and subsequent ... transmembrane and signaling domains from T-cell receptor signalling moieties. …

Ezatiostat

Ezatiostat is investigated in clinical trials for treating myelodysplastic syndrome. This compound belongs to the peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen...
Investigational
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... differentiates granulocytes and monocytes in HL60 cells. ... monocytes (white blood cells), erythrocytes (red blood cells) and platelets. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Umbilical Cord Blood Hematopoietic Stem Cells

The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … Specifically, the proliferation capacity of human umbilical cord blood mononuclear progenitor cells ( ... From the UCB, mononuclear cells are isolated and cultured in medium, expanded, and differentiated into ... of cytotoxicity and immunological reactions. …

Nonivamide

Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. The structures of DB06774 and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) . Nonivamide is a flavoring ingredient. Nonivamide is an...
Investigational
Matched Description: … Nonivamide is an organic compound and a capsaicinoid. ... It is an amide of pelargonic acid and _vanillylamine_. ... Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. …

Calcium

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the...
Nutraceutical
Matched Description: … Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, ... Calcium gluconate and calcium lactate are absorbed well by pregnant women. ... Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. …
Matched Mixtures name: … Hvp Chelated Cal/mag With Zinc and Vitamins C and D ... CALCIUM AND MAGNESIUM PLUS C,POTASSIUM AND ZINC TABLET ... Calci A and D Tab …
Matched Categories: … Antacids and Adsorbents ... Alimentary Tract and Metabolism ... multivitamins and calcium ... ascorbic acid (vit C) and calcium ... Calcium-Regulating Hormones and Agents …

Curcuma xanthorrhiza oil

Curcuma xanthorrhiza oil is extracted from Curcuma xanthorrhiza Roxb., a member of the ginger family (Zingiberaceae) that is widely distributed in the region of Southeastern Asia . Curcuma xanthorrhiza is also known as Javanese Turmeric or Temoe Lawak . For centuries, Curcuma xanthorrhiza oil has been used as a traditional...
Nutraceutical
Matched Description: … Curcumin is a mixture of dicinnamoylmethane derivatives and other phenolic and non-phenolic diarylheptanoids ... _Curcuma xanthorrhiza_ oil is found as an active ingredient in cosmetic and hygienic products, and marketing ... sesquiterpenes, 44.5% of xanthorrhizol, and a small amount of [DB01744] [F114]. …

Isoflavone

Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … The main soy isoflavones are mostly present in glycosylated forms and include [DB01645], [DB13182], and ... breast and prostate cancer [A33099]. ... legumes such as soy, peanut, green peas, chick peas and alfalfa [A33103]. …

VPM1002

The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... TB in newborns and TB recurrence in adults through post-exposure immunization. ... This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary …

Methoxyamine

Investigational

Cannabidivarin

Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within DB14009. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana . Compared to its homolog, DB09061, CBDV is shortened by two methyl (CH2) groups...
Investigational
Matched Description: … Notably, both [DB09061] and CBDV have demonstrated anticonvulsant activity in animal and human models ... CBD and CBDV have been shown to dose-dependently activate and then desensitize TRPV1 as well as TRPV2 ... and TRPA1 channels [A31560, A33334, A32976]. …

Nabiximols

Nabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species Cannabis sativa L. that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol). For trademark purposes, purified CBD is branded as Nabidiolex®, while THC is purified as the product Tetrabinex®. Sativex® is available in a...
Investigational
Matched Description: … resin of the marijuana plant, both of which interact with the cannabinoid receptors found in the human ... , and physiological effects. ... changes in emotional and cognitive processes. …
Matched Categories: … Cannabinoids and similars …
Displaying drugs 1976 - 1990 of 1990 in total