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Displaying drugs 2126 - 2150 of 15137 in total

Spinosad

Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species....
Approved
Investigational
Vet approved
Matched Description: … ) used in the topical treatment of head lice in children (four years old and older) and in adults. ... Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively ... Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also …

Simoctocog alfa

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … replaced by a 16 amino acid linker. ... The harvested product is concentrated and purified by a series of chromatography steps. ... + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Vancomycin

Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of...
Approved
Matched Iupac: … }.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid …
Matched Description: … kidneys and the inner ear. ... It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to ... liquid treatment option available for the the treatment of _Clostridium difficile_ associated diarrhea and …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Somatrem

Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disposition of short...
Approved
Investigational
Withdrawn
Matched Description: … Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …

Hydroflumethiazide

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Approved
Investigational
Withdrawn
Matched Description: … A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. …
Matched Categories: … hydroflumethiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Nepafenac

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Approved
Investigational
Matched Description: … It is used to treat pain and inflammation associated with cataract surgery. …

Voclosporin

Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE). LN is a significant cause of renal failure, morbidity, and death in patients with SLE. Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a...
Approved
Investigational
Matched Description: … Early and accurate intervention for LN is important in improving clinical outcomes. ... LN is a significant cause of renal failure, morbidity, and death in patients with SLE. ... [L31208] Voclosporin has demonstrated a more stable pharmacokinetic and pharmacodynamic relationship …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Tiopronin

Tiopronin is a prescription thiol drug used primarily in the treatment of severe homozygous cystinuria. Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation. Tiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion,...
Approved
Investigational
Matched Iupac: … 2-(2-sulfanylpropanamido)acetic acid …
Matched Description: … , and prevent kidney stone formation. ... protein, and urinary alkalinization. ... Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone …
Matched Categories: … Reducing and Complexing Thiol ... Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones …

Desvenlafaxine

Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly...
Approved
Investigational
Matched Description: … a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …

Doxepin

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but...
Approved
Investigational
Matched Description: … Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. ... [L5977] Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. ... [T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer …
Matched Categories: … Acid Reducers ... Hypnotics and Sedatives ... Antipruritics and Local Anesthetics ... Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Elivaldogene autotemcel

Elivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy, an X-linked genetic disorder characterized by missing or non-functional ABCD1 gene that codes for ALDP. ALDP is a key protein that normally...
Approved
Matched Description: … destruction of myelin, which is an insulating layer and essential component of nerves. ... Without sufficient levels of functional ALDP, VLCFAs accumulate in the body leading to inflammation and ... It was approved by the European Commission in July 2021 under the market name Skysona, and was later …
Matched Categories: … Cellular and Gene Therapy ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought ... Safety Communication requesting the manufacturer of Belviq (lorcaserin hydrochloride tablets, 10 mg) and ... hydrochloride extended-release tablets, 20 mg) to voluntarily withdraw these products from the U.S. market, and …
Matched Categories: … Alimentary Tract and Metabolism …

Lenalidomide

Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of thalidomide and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenalidomide is much safer and potent than thalidomide, with...
Approved
Matched Description: … and toxicities. ... exists as a racemic mixture of the active S(-) and R(+) forms. ... [A228708] However, lenalidomide is much safer and potent than thalidomide, with fewer adverse effects …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Iodohippurate sodium I-123

Approved

Cabozantinib

Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal...
Approved
Investigational
Matched Description: … Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. ... this same formulation gained additional approval in both the US and Canada in 2019 for the treatment ... a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Rapacuronium

Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm.
Approved
Withdrawn

Tesamorelin

Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and hyperlipidemia associated with antiretroviral therapy for HIV infection.
Approved
Investigational
Matched Description: … Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and hyperlipidemia …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …

Xylose

Xylose is a monosaccharide of the aldopentose type consisted of five carbon atoms and an aldehyde functional group. Xylose is a sugar isolated from wood. D-Xylose is a sugar widely used as a diabetic sweetener in food and beverage. Xylose has also been used as a diagnostic agent to observe...
Approved
Matched Description: … D-Xylose is a sugar widely used as a diabetic sweetener in food and beverage. ... Xylose is a monosaccharide of the aldopentose type consisted of five carbon atoms and an aldehyde functional ... immediately - but its metabolism results in a variety of substrates that can serve important nutritional and …

Ribociclib

Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play...
Approved
Investigational
Matched Description: … These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. ... that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Ceftaroline fosamil

Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Approved
Investigational
Matched Description: … treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and …

Glutathione

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Approved
Investigational
Nutraceutical
Matched Iupac: … (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid …
Matched Description: … for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

NADH

NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by...
Approved
Nutraceutical
Matched Iupac: … [(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid …
Matched Description: … electron carrier by being alternately oxidized (NAD+) and reduced (NADH). ... It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an ... NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …

Brivudine

Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.
Approved
Investigational
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Erdosteine

Erdosteine is a drug that causes a breakdown of mucus, also known as a mucolytic agent. It is a thiol derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis. This drug contains sulfhydryl groups which are released after erdosteine undergoes hepatic...
Approved
Investigational
Matched Iupac: … 2-({[(2-oxothiolan-3-yl)carbamoyl]methyl}sulfanyl)acetic acid …
Matched Description: … and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol ... Erdosteine 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly ... Erdosteine has been shown to be safe and well tolerated in clinical trials. …
Matched Categories: … Cough and Cold Preparations …

Alatrofloxacin

Alatrofloxacin is a fluoroquinolone antibiotic developed by Pfizer, delivered as a mesylate salt. It was withdrawn from the U.S. market in 2001.
Approved
Withdrawn
Matched Iupac: … [3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid …
Displaying drugs 2126 - 2150 of 15137 in total