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Displaying drugs 2151 - 2175 of 2438 in total
Ditazole
Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade name Ageroplas.
Experimental
Withdrawn
Matched Categories: … Platelet Aggregation Inhibitors Excl. Heparin …
Rabusertib
Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer.
Investigational
Matched Categories: … Protein Kinase Inhibitors …
Pilaralisib
Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Glioblastoma, and Breast Cancer, among others.
Investigational
Matched Categories: … Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
Endothelin-1
Endothelin 1 is under investigation in clinical trial NCT00745693 (The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin).
Investigational
Matched Categories: … Endothelin-1, antagonists & inhibitors …
Pranlukast
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Investigational
Matched Categories: … Cytochrome P-450 CYP2C9 Inhibitors ... Cytochrome P-450 Enzyme Inhibitors ... Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) …
Prostaglandin D2
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
Investigational
Matched Categories: … Prostaglandin D2, antagonists & inhibitors …
1-deoxymannojirimycin
An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. [PubChem]
Experimental
Matched Categories: … Enzyme Inhibitors …
Talabostat
Investigational
Matched Categories: … Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, antagonists & inhibitors …
Voxtalisib
Voxtalisib has been used in trials studying the treatment of Cancer, Melanoma, Lymphoma, Glioblastoma, and Breast Cancer, among others.
Investigational
Matched Categories: … Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
Selisistat
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
Experimental
Matched Categories: … Sirtuin 1, antagonists & inhibitors …
Basifungin
Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor , .
Experimental
Matched Categories: … Enzyme Inhibitors …
Alaproclate
Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity observed in animal studies. Alaproclate has also been found to act as a non-competitive NMDA receptor antagonist although without discriminative...
Experimental
Matched Categories: … Neurotransmitter Uptake Inhibitors ... Selective Serotonin Reuptake Inhibitors …
Cefacetrile
A derivative of 7-aminocephalosporanic acid.
Experimental
Vet approved
Matched Categories: … OAT1/SLC22A6 inhibitors ... OAT3/SLC22A8 Inhibitors …
Paramethasone
A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia,...
Experimental
Matched Categories: … Cytochrome P-450 CYP3A Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors ... Cytochrome P-450 Enzyme Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Tivantinib
Tivantinib has been investigated in Solid Tumors.
Investigational
Matched Categories: … Proto-Oncogene Proteins c-met, antagonists & inhibitors …
CGI-1842
JI-101 has been used in trials studying the treatment of Cancer, Colon Cancer, Neuroendocrine, Ovarian Cancer, and Advanced Solid Tumors.
Investigational
Matched Categories: … Receptor, EphB4, antagonists & inhibitors …
Puromycin
Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses.
Experimental
Matched Categories: … Enzyme Inhibitors ... Protein Synthesis Inhibitors …
Henatinib
Henatinib has been used in trials studying the treatment of Advanced Solid Cancer.
Investigational
Matched Categories: … Vascular Endothelial Growth Factors, antagonists & inhibitors …
SNS-314
SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis, leading to multiple rounds of endoreduplication and eventually cell death. SNS-314 inhibits tumor growth in a variety of preclinical models, and...
Investigational
Matched Categories: … Protein Kinase Inhibitors …
Fradafiban
Investigational
Matched Categories: … Platelet Glycoprotein GPIIb-IIIa Complex, antagonists & inhibitors …
Displaying drugs 2151 - 2175 of 2438 in total