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Displaying drugs 2201 - 2225 of 2438 in total
XL-888
XL888 has been used in trials studying the treatment of Cancer and Melanoma.
Investigational
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
Tyrosinase
Tyrosinase is a multi-copper-containing multifunctional metalloenzyme with 4 possible oxidation states.[A231829, A231834, A231839] It is responsible for producing melanin pigment across the phylogenetic spectrum.[A231829, A231834, A231839]
Within mammals, tyrosinase is found specifically in melanocytes in a glycosylated form and plays a critical role in regulating the process of melanin biosynthesis...
Investigational
Matched Categories: … Monophenol Monooxygenase, antagonists & inhibitors …
Glyceraldehyde-3-Phosphate Dehydrogenase
Investigational
Matched Categories: … Glyceraldehyde-3-Phosphate Dehydrogenases, antagonists & inhibitors …
ORG-34517
ORG-34517 is currently under investigation by Organon for the treatment of depression. It has potential to treat a number of diseases such as Cushing’s disease, hypertension, diabetes, glaucoma etc, in which the activity of metabolites corticosterone and cortisol is high.
Investigational
Matched Categories: … Receptors, Glucocorticoid, antagonists & inhibitors …
Refanezumab
Refanezumab is under investigation in clinical trial NCT00833989 (Safety Escalating Repeat IV, in Stroke Patients).
Investigational
Matched Categories: … Myelin-Associated Glycoprotein, antagonists & inhibitors …
Volagidemab
Volagidemab is under investigation in clinical trial NCT03117998 (Multiple Dose Study to Evaluate the Efficacy, Safety and Pharmacodynamics of REMD-477 in Subjects With Type 1 Diabetes Mellitus).
Investigational
Matched Categories: … Receptors, Glucagon, antagonists & inhibitors …
Coumaphos
This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a dip or wash. Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas.
Vet approved
Matched Categories: … Enzyme Inhibitors ... Cholinesterase Inhibitors …
Monensin
Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
Experimental
Vet approved
Matched Categories: … Enzyme Inhibitors ... P-glycoprotein inhibitors …
Icotinib
Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. was given a “May Proceed” from the US FDA to conduct a Phase I study for the...
Experimental
Investigational
Matched Categories: … Protein Kinase Inhibitors ... Tyrosine Kinase Inhibitors ... Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Voacamine
Voacamine is an alkaloid isolated from the bark of the Pescheria fuchsiae folia tree. It is an antimalarial drug approved for use in several African countries. Voacamine is also under investigation for use in modulating multidrug-resistance in tumor cells.
Experimental
Matched Categories: … P-glycoprotein inhibitors …
TG100-115
An NSAID that inhibits PI-3K gamma and delta.
Investigational
Matched Categories: … Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
Gosogliptin
Gosogliptin has been used in trials studying the treatment of Renal Insufficiency, Chronic.
Investigational
Matched Categories: … DPP-IV Inhibitors …
MK-8245
MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus.
Investigational
Matched Categories: … Stearoyl-CoA Desaturase, antagonists & inhibitors …
Camrelizumab
Camrelizumab is under investigation in clinical trial NCT03417895 (SHR-1210 Combined With Apatinib in Treatment of ED-SCLC After Failure of First Line Standard Therapy).
Investigational
Matched Categories: … Immune Checkpoint Inhibitors …
Duvoglustat
An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.
Investigational
Matched Categories: … Enzyme Inhibitors …
Dersalazine
Investigational
Matched Categories: … Platelet Activating Factor, antagonists & inhibitors …
Talopram
Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed.
Experimental
Matched Categories: … Adrenergic Uptake Inhibitors …
Tabalumab
Tabalumab has been used in trials studying the treatment of Autoimmune Disease, Rheumatoid Arthritis, Kidney Failure, Chronic, Connective Tissue Disease, and Systemic Lupus Erythematosus, among others.
Investigational
Matched Categories: … B-Cell Activating Factor, antagonists & inhibitors …
Dinaciclib
Dinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others.
Investigational
Matched Categories: … Cyclin-Dependent Kinases, antagonists & inhibitors …
Displaying drugs 2201 - 2225 of 2438 in total