Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 2451 - 2475 of 15130 in total

Duloxetine

Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a...
Approved
Matched Description: … [label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. ... Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. ... Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more. …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …

Amiodarone

Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone...
Approved
Investigational
Matched Description: … indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and ... Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Biperiden

A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Approved
Investigational
Matched Description: … A muscarinic antagonist that has effects in both the central and peripheral nervous systems. ... It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. ... It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine …

Hemin

Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs …

Zinc dibutyldithiocarbamate

Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. Sensitivity to zinc dibutyldithiocarbamate may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Antithrombin Alfa

Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.
Approved
Investigational

Alverine

Alverine is a smooth muscle relaxant used to relieve cramps or spasms of the stomach and intestines. It is therefore useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain.
Approved
Investigational
Matched Description: … It is therefore useful in treating irritable bowel syndrome (IBS) and similar conditions. ... Alverine is a smooth muscle relaxant used to relieve cramps or spasms of the stomach and intestines. …
Matched Categories: … Alimentary Tract and Metabolism …

Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Procyclidine

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Approved
Matched Description: … extrapyramidal disorders and in parkinsonism. ... A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced …

Diphenidol

Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.
Approved
Investigational
Withdrawn
Matched Description: … Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. …

Albumin iodinated I-131 serum

Iodinated I-131 serum albumin is a radiopharmaceutical agent used for several diagnostic purposes, including the determination of body fluid volumes and the imaging of certain tissues.
Approved
Matched Description: … radiopharmaceutical agent used for several diagnostic purposes, including the determination of body fluid volumes and …

Glasdegib

Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionality. The great lipophilicity of this group of compounds...
Approved
Investigational
Matched Description: … [A40310] Glasdegib was developed by Pfizer Inc and approved on November 21, 2018 by the FDA for the ... interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and ... monotherapy is limited, the landmark Phase 2 Bright AML 1003 trial showed a superior overall survival and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Human papillomavirus type 18 L1 capsid protein antigen

Human papillomavirus type 18 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Description: … by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …

Benralizumab

Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils and basophils. It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R,...
Approved
Investigational
Matched Description: … global biologic research and development arm. ... specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils and ... [A31294] It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Deferiprone

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired....
Approved

Alirocumab

Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Dimethicone 410

Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%....
Approved
Matched Description: … It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated …

Pergolide

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome....
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine ... The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007. …
Matched Categories: … Ergot Alkaloids and Derivatives …

Anagrelide

Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythemia treatments (e.g....
Approved
Matched Description: … [busulfan], [hydroxyurea]) and may be better tolerated.[A214274] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Carbinoxamine

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Description: … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and ... -2 infection[A220053] showed a single immunization with the vaccine-elicited neutralizing responses and ... protected against SARS-CoV-2 induced pneumonia and mortality, providing protection against the disease …

Tranylcypromine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Description: … monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and ... It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). ... Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …

Verteporfin

Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red...
Approved
Investigational
Matched Description: … as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and ... Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light ... wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and …

Gallamine triethiodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may...
Approved
Matched Description: … may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. ... gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and …

Formaldehyde

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor...
Approved
Vet approved
Matched Description: … , and as a laboratory fixative or preservative. ... Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. ... In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant …
Displaying drugs 2451 - 2475 of 15130 in total