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Displaying all 7 targets
Cyclin-dependent kinase 4
Matched Polypeptides specific function: … of the cyclin D-CDK4 complex. ... Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the ... Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. …
G1/S-specific cyclin-D1
Matched Polypeptides specific function: … of the cyclin D-CDK4 complex. ... Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the ... Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. …
Cyclin-dependent kinase inhibitor 1
Matched Polypeptides general function: … At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. ... Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity …
Cyclin-dependent kinase 7
Matched Polypeptides specific function: … Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. ... CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus …
Tyrosine-protein kinase Yes
Matched Polypeptides specific function: … Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating …
Calcium/calmodulin-dependent protein kinase type 1
Matched Polypeptides general function: … Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts …
activator protein 1
Matched Polypeptides general function: … Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). …
Displaying all 7 targets