Voltage-dependent L-type calcium channel subunit alpha-1C

BE0000430ProteinHumansCACNA1C

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). It is acted on by 29 drugs in DrugBank.

Gene name
CACNA1C
UniProtKB entry
Q13936Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,221 residues · 248,974 Da
Also known as
CACH2 · CACN2 · CACNL1A1 · Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle · CCHL1A1

Resolves to

Protein
UniProtQ13936UniProt nameCAC1C_HUMAN
Gene
HGNCHGNC:1390NCBI Gene775GeneCardsCACNA1C
Pharmacology
IUPHAR/GtoPdb529KEGGhsa:775
Structure
PDB1T0JPDB2BE6PDB2F3Y
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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102+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent L-type calcium channel subunit alpha-1C, how selective are they, and which programs against it are still in active trials?

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