72 kDa type IV collagenase

BE0000642ProteinHumansMMP2

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. It is acted on by 32 drugs in DrugBank.

Gene name
MMP2
UniProtKB entry
P08253Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
660 residues · 73,882 Da
Also known as
3.4.24.24 · 72 kDa gelatinase · CLG4A · Gelatinase A · Matrix metalloproteinase-2

Resolves to

Protein
UniProtP08253UniProt nameMMP2_HUMAN
Gene
HGNCHGNC:7166NCBI Gene4313GenBank180671GeneCardsMMP2
Pharmacology
IUPHAR/GtoPdb1629KEGGhsa:4313
Structure
PDB1CK7PDB1CXWPDB1EAK
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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35GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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118+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 72 kDa type IV collagenase, how selective are they, and which programs against it are still in active trials?

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