Identification

Brand Names
Ultratag
Generic Name
Stannous chloride
DrugBank Accession Number
DB11056
Background

Stannous chloride is used as a source of tin in radiopharmaceutical kits. Tin reduces technetium-99m, the active radiological agent, allowing it to form a complex with phosphate-containing moeities 1. These complexes localize primarily in bone (40-50%) and infracted myocardium (0.01-0.02%/g of tissue) allowing for imaging of areas of altered osteogenesis or necrotic heart tissue Label.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 189.62
Monoisotopic: 189.839901985
Chemical Formula
Cl2Sn
Synonyms
  • Stannous chloride anhydrous
  • Stannous chloride,anhydrous
  • Tin dichloride

Pharmacology

Indication

Stannous chloride is a component of technetium-99m agents indicated for imaging of the skeleton for areas of altered osteogenesis or in the detection of infarcted heart tissue Label.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Stannous chloride itself is not known to produce a pharmacological effect at the dosages used clinically.

Mechanism of action

Stannous chloride acts as a reducing agent for technetium-99m allowing formation of a Tc99m-Sn-pyrophosphate complex in combination sodium pyrophosphate 1,Label. See Technetium Tc-99m pyrophosphate for information on the active agent.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Stannous chloride dihydrate1BQV3749L510025-69-1GATSHYKZJFLTJA-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Ultratag RBC0.05 mg/9.5mgIntravenousCurium US LLC1991-06-10Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
High Potency Multivitamins & Minerals CapletsStannous chloride (0.01 mg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium phosphate, dibasic (125 mg) + Calcium Phosphate (175 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium oxide (100 mg) + Manganese sulfate (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (50 mg) + Potassium chloride (55 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Sodium selenate (50 mcg) + Silicon dioxide (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (3 mg) + Vitamin A acetate (3500 unit) + Zinc citrate (20 mg) + alpha-Tocopherol acetate (50 unit)TabletOralAshbury Research CorporationNot applicableNot applicableCanada flag
Multivitamins and Minerals TabletsStannous chloride (0.010 mg) + Ascorbic acid (120 mg) + Beta carotene (1000 unit) + Biotin (40 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (120 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (18 mcg) + Ferrous fumarate (15 mg) + Folic acid (0.4 mg) + Magnesium (50 mg) + Manganese (4 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Potassium (80 mg) + Potassium Iodide (0.150 mg) + Potassium chloride (72 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (5.1 mg) + Sodium selenite (70 mcg) + Silicon (4 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (4.5 mg) + Vitamin A (4000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralPharmetics (2011) Inc.2004-06-032009-07-30Canada flag
Spectrum Performa Multivitamins and Minerals TabletsStannous chloride (0.01 mg) + Ascorbic acid (120 mg) + Beta carotene (1000 unit) + Biotin (40 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (120 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (18 mcg) + Ferrous fumarate (18 mg) + Folic acid (0.4 mg) + Magnesium (50 mg) + Manganese (4 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Potassium (80 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (72 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (5.1 mg) + Sodium selenite (70 mcg) + Silicon (4 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (4.5 mg) + Vitamin A (4000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralPharmetics (2011) Inc.2003-03-122009-07-30Canada flag
Technescan PYPStannous chloride dihydrate (3.2 mg/10mL) + Sodium pyrophosphate (11.9 mg/10mL)Injection, powder, lyophilized, for solutionIntravenousCurium US LLC2015-10-14Not applicableUS flag
Technescan PYPStannous chloride dihydrate (3.2 mg/10mL) + Technetium Tc-99m pyrophosphate (11.9 mg/10mL)Injection, powder, lyophilized, for solutionIntravenousMallinckrodt2009-03-202017-07-01US flag

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal salts
Sub Class
Post-transition metal chlorides
Direct Parent
Post-transition metal chlorides
Alternative Parents
Inorganic tin salts / Inorganic chloride salts
Substituents
Inorganic chloride salt / Inorganic salt / Inorganic tin salt / Post-transition metal chloride
Molecular Framework
Not Available
External Descriptors
inorganic chloride, tin molecular entity (CHEBI:78067)
Affected organisms
Not Available

Chemical Identifiers

UNII
R30H55TN67
CAS number
7772-99-8
InChI Key
AXZWODMDQAVCJE-UHFFFAOYSA-L
InChI
InChI=1S/2ClH.Sn/h2*1H;/q;;+2/p-2
IUPAC Name
λ²-tin(2+) ion dichloride
SMILES
[Cl-].[Cl-].[Sn++]

References

General References
  1. Thrall JH: Technetium-99m labeled agents for skeletal imaging. CRC Crit Rev Clin Radiol Nucl Med. 1976;8(1):1-31. [Article]
ChemSpider
22887
RxNav
314853
ChEBI
78067
Wikipedia
Tin(II)_chloride
FDA label
Download (105 KB)
MSDS
Download (50.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
Injection, powder, lyophilized, for solutionIntravenous
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)38MSDS
water solubilityFreely solubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility65.4 mg/mLALOGPS
logP0.66ALOGPS
logP0.61ChemAxon
logS-0.46ALOGPS
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity5.62 m3·mol-1ChemAxon
Polarizability2.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at December 03, 2015 16:51 / Updated at February 13, 2021 11:02