NAD(P)H dehydrogenase [quinone] 1

BE0001184ProteinHumansNQO1

Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. It is acted on by 29 drugs in DrugBank.

Gene name
NQO1
UniProtKB entry
P15559Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
274 residues · 30,867 Da
Also known as
1.6.5.2 · Azoreductase · DIA4 · DT-diaphorase · DTD

Resolves to

Protein
UniProtP15559UniProt nameNQO1_HUMAN
Gene
HGNCHGNC:2874NCBI Gene1728GenBank189246GeneCardsNQO1
Pharmacology
KEGGhsa:1728
Structure
PDB1D4APDB1DXOPDB1GG5
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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5Metabolic reactionsDrug transformations it catalyses, substrate to product
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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72+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NAD(P)H dehydrogenase [quinone] 1, how selective are they, and which programs against it are still in active trials?

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