Casein kinase II subunit alpha

BE0001209ProteinHumansCSNK2A1

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391,... It is acted on by 30 drugs in DrugBank.

Gene name
CSNK2A1
UniProtKB entry
P68400Swiss-Prot
Cellular location
Nucleus
Residues / weight
391 residues · 45,143 Da
Also known as
2.7.11.1 · CK II alpha · CK2A1

Resolves to

Protein
UniProtP68400UniProt nameCSK21_HUMAN
Gene
HGNCHGNC:2457NCBI Gene1457GenBank598147GeneCardsCSNK2A1
Pharmacology
IUPHAR/GtoPdb1549KEGGhsa:1457
Structure
PDB1JWHPDB1NA7PDB1PJK
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
24GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
113+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Casein kinase II subunit alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In