Aldehyde oxidase

BE0003539ProteinHumansAOX1

Primarily catalyzes oxidation reactions of a broad range of drug and xenobiotic substrates and participates in their metabolism through oxidative biotransformation (PubMed:14709625, PubMed:20444863, PubMed:22279051, PubMed:22996261, PubMed:23857892, PubMed:26322824, PubMed:26842593, PubMed:34415167, PubMed:7786031, PubMed:9224775). It is acted on by 33 drugs in DrugBank.

Gene name
AOX1
UniProtKB entry
Q06278Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,338 residues · 147,917 Da
Also known as
1.2.3.1 · Aldehyde oxidase 1 · AO · Aryl-aldehyde oxidase · Azaheterocycle hydroxylase

Resolves to

Protein
UniProtQ06278UniProt nameAOXA_HUMAN
Gene
HGNCHGNC:553NCBI Gene316GenBank438656GeneCardsAOX1
Pharmacology
IUPHAR/GtoPdb3186KEGGhsa:316
Structure
PDB4UHWPDB4UHXPDB5EPG
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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15Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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87+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldehyde oxidase, how selective are they, and which programs against it are still in active trials?

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