Penicillin-binding protein 2a
Details
- Name
- Penicillin-binding protein 2a
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- pbp2a
- UniProtKB Entry
- Q8DNB6TrEMBL
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- NCBI Taxonomy ID
- 171101
- Amino acid sequence
>lcl|BSEQ0022113|Penicillin-binding protein 2a MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGPIRKFWRRYHLTKIILI LGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKEAGALSGQKGTYVELTDIS KNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGSTITQQLAKNAYLSQDQTVER KAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVEDASKKYFGVSASEVSLDQAATL AGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYIDKNQETEAAEVDMTSQLHDKYEGK ISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYRIYTELDQNYQANMQIVYENTSLFPRA EDGTFAQSGSVALEPKTGGVRGVVGQVADNDKTGFRNFNYATQSKRSPGSTIKPLVVYTP AVEAGWALNKQLDNHTMQYDSYKVDNYAGIKTSREVPMYQSLAESLNLPAVATVNDLGVD KAFEAGEKFGLNMEKVDRVLGVALGSGVETNPLQMAQAYAAFANEGLMPEAHFISRIENA SGQVIASHKNSQKRVIDKSVADKMTSMMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNP EYTSDQWVIGYTPDVVISHWLGFPTTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTF TVENAYKQNGIAPANTKRQVQTNDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQ TIWDSIVNLFR
- Number of residues
- 731
- Molecular Weight
- 80797.94
- Theoretical pI
- Not Available
- GO Classification
- Functionspenicillin binding / peptidoglycan glycosyltransferase activity / transferase activity, transferring acyl groupsComponentsintegral component of membrane
- General Function
- Cell wall formation. Synthesis of cross-linked peptidoglycan (PG) from the lipid intermediates (By similarity). Binds dansylated lipid II and catalyzes the polymerization of glycan chains (PubMed:12867450, PubMed:22487093). Hydrolyzes S2d (N-benzoyl-D-alanylmercaptoacetic acid) molecule, a synthetic thiolester analog of cell wall stem peptide (PubMed:10217767, PubMed:22487093). Active against bocillin, a fluorescent penicillin. No transpeptidase activity with non-fluorescent lysine-containing lipid II as substrate (PubMed:22487093).
- Specific Function
- acyltransferase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 57-77
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022114|Penicillin-binding protein 2a (pbp2a) ATGAAATTAGATAAATTATTTGAGAAATTTCTTTCTCTTTTTAAAAAAGAAACAAGTGAA CTAGAGGACTCTGATTCTACTATCTTACGTCGCTCTCGTAGTGATCGAAAAAAATTAGCC CAAGTAGGTCCGATTCGAAAATTCTGGCGTCGTTATCATCTAACAAAGATTATCCTTATA CTAGGTTTGAGTGCAGGCTTGCTAGTTGGAATCTATTTGTTTGCTGTAGCCAAGTCGACC AATGTCAATGATTTGCAAAATGCCTTGAAAACTCGGACTCTTATTTTTGACCGTGAAGAA AAAGAGGCTGGTGCCTTGTCTGGTCAAAAGGGAACCTATGTTGAGCTGACTGACATCAGT AAAAACTTGCAGAATGCTGTTATTGCGACAGAAGACCGTTCTTTCTATAAAAATGACGGG ATTAACTATGGCCGTTTCTTCTTGGCTATTGTCACTGCTGGACGTTCAGGTGGTGGCTCT ACCATTACCCAACAGCTGGCTAAAAACGCCTATTTATCGCAGGATCAAACTGTTGAGAGA AAAGCGAAAGAATTTTTCCTTGCCTTAGAATTAAGCAAAAAATATAGTAAGGAGCAAATT CTAACCATGTACCTTAACAACGCTTATTTTGGAAATGGTGTGTGGGGTGTAGAAGATGCG AGTAAGAAATACTTTGGAGTTTCTGCATCAGAAGTGAGTCTGGATCAAGCTGCGACTCTG GCAGGGATGCTCAAGGGGCCGGAACTGTATAATCCCTTGAATTCCGTAGAAGATTCTACT AATCGGCGCGATACTGTCTTGCAGAATATGGTTGCAGCAGGATATATTGATAAAAACCAA GAAACCGAAGCTGCTGAAGTTGATATGACTTCGCAATTGCACGATAAGTATGAAGGAAAA ATCTCAGATTACCGTTACCCCTCTTATTTTGATGCGGTGGTTAATGAAGCTGTTTCCAAG TATAATCTAACAGAGGAAGAGATTGTCAATAATGGCTACCGCATTTACACAGAGCTGGAC CAAAACTACCAAGCAAATATGCAGATTGTTTATGAAAACACATCGCTATTTCCGAGGGCA GAGGATGGAACGTTTGCTCAATCAGGAAGTGTAGCTCTCGAACCGAAAACAGGGGGAGTT CGTGGAGTTGTCGGTCAAGTTGCTGACAATGATAAAACTGGATTCCGGAATTTCAACTAT GCAACCCAATCAAAGCGTAGTCCTGGTTCTACAATTAAGCCTTTAGTTGTTTATACACCA GCAGTTGAAGCAGGCTGGGCTTTGAATAAGCAGTTGGATAACCATACCATGCAGTATGAT AGCTATAAGGTTGATAACTATGCAGGGATCAAAACAAGTCGAGAAGTTCCTATGTATCAA TCCTTGGCAGAATCGCTTAATCTACCTGCTGTTGCCACTGTTAATGATTTGGGTGTTGAC AAGGCTTTTGAGGCAGGCGAAAAATTCGGACTCAACATGGAAAAGGTCGACCGTGTTCTT GGTGTCGCCTTGGGAAGCGGTGTTGAAACCAACCCTCTTCAAATGGCTCAAGCATACGCT GCCTTTGCAAATGAAGGTTTAATGCCTGAAGCTCATTTTATTAGTAGAATTGAAAATGCT AGTGGACAAGTTATTGCGAGTCATAAAAATTCACAAAAACGGGTGATTGATAAGTCTGTA GCTGACAAGATGACCAGTATGATGTTGGGGACTTTCACCAACGGTACCGGTATTAGTTCA TCGCCTGCAGACTATGTCATGGCAGGGAAAACTGGAACAACTGAAGCAGTTTTCAATCCG GAGTACACAAGTGACCAGTGGGTAATTGGTTATACTCCGGATGTAGTGATTAGCCACTGG CTTGGCTTTCCGACCACTGATGAAAATCACTATCTAGCTGGCTCTACTTCAAACGGTGCA GCTCATGTCTTTAGAAACATTGCCAATACTATTTTACCTTATACGCCAGGAAGTACCTTT ACGGTTGAAAATGCTTATAAGCAAAATGGAATTGCACCAGCCAATACAAAAAGACAAGTA CAAACCAATGATAATAGCCAGACAGATGATAATTTGTCTGATATTCGAGGGCGTGCGCAA AGTCTAGTAGATGAGGCTAGCCGGGCTATCTCAGATGCGAAGATTAAGGAAAAGGCTCAA ACAATATGGGATTCGATAGTCAATCTATTTCGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8DNB6 UniProtKB Entry Name Q8DNB6_STRR6 KEGG ID spr:spr1823 NCBI Gene ID 933569 - General References
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cefotaxime approved yes target inhibitor Details Piperacillin approved yes target inhibitor Details Nafcillin approved, investigational yes target inhibitor Details Ampicillin approved, vet_approved yes target inhibitor Details Dicloxacillin approved, investigational, vet_approved yes target inhibitor Details Amdinocillin investigational, withdrawn yes target inhibitor Details Meticillin approved, investigational yes target inhibitor Details Cefalotin approved, investigational, vet_approved yes target inhibitor Details Oxacillin approved, investigational yes target inhibitor Details Cefoxitin approved yes target inhibitor Details Cephalexin approved, investigational, vet_approved yes target inhibitor Details Cephalosporin C experimental yes target inhibitor Details Azidocillin experimental yes target inhibitor Details Hetacillin approved, vet_approved, withdrawn yes target inhibitor Details