- Antirheumatic Agents
- Accession Number
Drugs that are used to treat RHEUMATOID ARTHRITIS.
Drug Drug Description Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. Leflunomide A pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Etanercept A protein therapy based on the binding fragment of the tumour necrosis factor alpha receptor used to treat severe rheumatoid arthritis and moderate to severe plaque psoriasis. Anakinra A recombinant form of human interleukin-1 receptor antagonist used in the treatment of rheumatoid arthritis and neonatal-onset multisystem inflammatory disease. Adalimumab A monoclonal anti-tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. Infliximab A monoclonal anti tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. Rituximab A monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Nabumetone An NSAID used to treat osteoarthritis and rheumatoid arthritis. Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Tolmetin An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. Cyclophosphamide A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Rofecoxib A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Sulindac An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Sulfasalazine An anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Levamisole Levamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Bromfenac An NSAID used to treat postoperative pain and inflammation of the eye. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Auranofin An antirheumatic used to treat active, progressive, or destructive forms of inflammatory arthritis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Probenecid A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Abatacept A disease-modifying antirheumatic drug (DMARD) used for the management of moderate-to-severe active rheumatoid arthritis and active polyarticular juvenile idiopathic arthritis as monotherapy or in combination with other DMARDs. Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Etoricoxib For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Oxyphenbutazone A nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. Nimesulide For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Zomepirac Zomepirac was indicated for the management of mild to severe pain. Tienilic acid For the treatment of hypertension. Febuxostat A xanthine oxidase inhibitor used for the management of chronic hyperuricemia in adults with gout who have an inadequate response or intolerance to allopurinol. Pirfenidone An agent used for the treatment of idiopathic pulmonary fibrosis (IPF). PTC299 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Glatiramer An immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS). Andrographolide Investigated for use/treatment in ulcerative colitis. Icatibant A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). Exisulind Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications. Belatacept A selective T-cell costimulation blocker used in the prophylaxis of organ rejection in adult patients receiving a kidney transplant. Lornoxicam For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases. Aceclofenac Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Seratrodast Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Azapropazone Not Available Felbinac Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Ferulic acid Not Available Parecoxib A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Certolizumab pegol A tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis. Kebuzone Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Etofenamate Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID). Epirizole Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain. Aurothioglucose A gold compound used in the treatment of rheumatoid arthritis. Loxoprofen Loxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders. In addition to its effects on pain, it is an antipyretic and anti-inflammatory... Droxicam Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Clonixin Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. Sodium aurothiomalate A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Methyl salicylate A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons. Borage oil Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as... Evening primrose oil Evening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical... Tepoxalin Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused... Flunixin Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form.... Lesinurad A uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy. Curcumin No approved therapeutic indications. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Semapimod Semapimod has been used in trials studying the treatment of Crohn Disease. Bucillamine Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. Binetrakin Binetrakin has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, Non-Hodgkin's Lymphoma (NHL), Myelodysplastic Syndrome (MDS), and Leukemia, Acute Myelogenous (AML), among others. Benzbromarone Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia. Lisofylline Lisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Indobufen Indobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Apocynin Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Tinoridine Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults). Parthenolide Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis. Serrapeptase Serrapeptase is a proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections. Serratiopeptidase is under investigation in clinical trial NCT02493179 (Efficacy Evaluation of the (Serodase 5 mg Tablet)... Alclofenac Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Fentiazac Not Annotated Tribenoside Anti-inflammatory agent used in edema of extremities, varicose veins & phlebitis. Suxibuzone Not Annotated Benziodarone Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France... Bumadizone Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Flunoxaprofen Not Annotated Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Feprazone Not Annotated Difenpiramide Not Annotated Nifenazone Not Annotated Lonazolac Not Annotated Tenidap Not Annotated Bendazac Prior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the... Pranoprofen Not Annotated Propyphenazone Not Annotated Proglumetacin Not Annotated Guacetisal Not Annotated Bevonium Not Annotated Ethenzamide Not Annotated Carbaspirin calcium Not Annotated Mofebutazone Not Annotated Proquazone Not Annotated Benorilate Not Annotated Pirprofen Not Annotated Aurotioprol Not Annotated Acemetacin Acemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation... Tisopurine Not Annotated Imidazole salicylate Not Annotated Palmidrol A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food... Golimumab A TNFα inhibitor used in the symptomatic treatment of various active inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Tocilizumab An interleukin-6 (IL-6) receptor antagonist used to treat Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA). Tofacitinib A Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Niflumic acid Used in the treatment of rheumatoid arthritis. Sarilumab A monoclonal antibody used to treat moderate to severe rheumatoid arthritis who have responded poorly or are intolerant of other DMARDs. SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Taxifolin Not Available Rifamycin An antibacterial used to treat traveler's diarrhea. Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). Licofelone For the management of osteoarthritis. Ecallantide A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE). Dexketoprofen For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache . Verinurad Verinurad has been used in trials studying the basic science and treatment of Gout, Gout and Hyperuricemia, and Gout and Asymptomatic Hyperuricemia. Mavrilimumab Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis. Oxaceprol Not Annotated Upadacitinib An oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis in adult patients who did not respond well to methotrexate. Ursolic acid Not Annotated MIV-711 Not Annotated Fepradinol Not Annotated Gold sodium thiosulfate Not Annotated Peoniflorin Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis). Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina).
- Drugs & Drug Targets