Gastric Acid Lowering Agents

Name
Gastric Acid Lowering Agents
Accession Number
DBCAT003882
Description

Drugs used in the treatment of excessive production of gastric acid.

Drugs
DrugDrug Description
PantoprazoleA proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.
OmeprazoleA proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.
LansoprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
EsomeprazoleA proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.
RabeprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DexlansoprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DexrabeprazoleNot Annotated
Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
Aluminum hydroxideAn antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
MagaldrateAn antacid used to treat various conditions in the GI tract, such as esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux.
AluminiumA metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
HydrotalciteNot Annotated
Calcium carbonateAn ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
Magnesium hydroxideAn inorganic compound used as a laxative and antacid.
Magnesium trisilicateAn antacid used for the symptomatic treatment of peptic ulcers.
Bismuth subnitrateA medication used as an antacid.
Magnesium silicateMagnesium silicate is used to absorb moisture, prevent caking, and to improve the feel of a product. In the pharmaceutical companies, it is used as a dietary supplement, as part...
Aluminium acetoacetateAluminium acetoacetate is an aluminum containing antacid.
Magnesium peroxideNot Annotated
AlmasilateAlmasilate is indicated for use as an antacid for the neutralization of excess stomach acid . It is subsequently also used for the symptomatic treatment of diseases where it is...
Aluminium glycinateNot Annotated
AloglutamolAloglutamol is an antacid salt of aluminium, gluconic acid, and tris. Proprietary names include Altris, Pyreses, Tasto and Sabro.
Calcium silicateNot Annotated
Sodium bicarbonateA compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Aluminium phosphateNot Available
RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
FamotidineA histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
LafutidineLafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD).
LavoltidineLavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease.
MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
MetiamidePotential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
NiperotidineNot Annotated
NizatidineAn H2 receptor antagonist used to treat GERD and a variety of ulcers.
Roxatidine acetateFor the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also...
Salvianolic acid ASalvianolic acid A is under investigation in clinical trial NCT03908242 (Phase I Study of Continuous Administration of Salvianolic Acid A Tablet).
IlaprazoleIlaprazole has been investigated in Helicobacter Infections.
Sodium zirconium cyclosilicateA potassium binder used to treat hyperkalemia.
VonoprazanVonoprazan has been used in trials studying the treatment of Erosive Esophagitis.
Drugs & Drug Targets
DrugTargetType
PantoprazolePotassium-transporting ATPase alpha chain 1target
PantoprazoleCytochrome P450 2C19enzyme
PantoprazoleCytochrome P450 3A4enzyme
PantoprazoleP-glycoprotein 1transporter
PantoprazoleATP-binding cassette sub-family G member 2transporter
PantoprazoleSolute carrier family 22 member 8transporter
PantoprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
OmeprazolePotassium-transporting ATPase alpha chain 1target
OmeprazoleCytochrome P450 2C19enzyme
OmeprazoleCytochrome P450 3A4enzyme
OmeprazoleCytochrome P450 2C9enzyme
OmeprazoleCytochrome P450 1A2enzyme
OmeprazoleCanalicular multispecific organic anion transporter 2transporter
OmeprazoleP-glycoprotein 1transporter
OmeprazoleATP-binding cassette sub-family G member 2transporter
OmeprazoleCytochrome P450 1A1enzyme
OmeprazoleCytochrome P450 1B1enzyme
OmeprazoleCytochrome P450 2C18enzyme
OmeprazoleCytochrome P450 2C8enzyme
OmeprazoleCytochrome P450 2D6enzyme
OmeprazoleAryl hydrocarbon receptortarget
LansoprazolePotassium-transporting ATPase alpha chain 1target
LansoprazoleCytochrome P450 2C19enzyme
LansoprazoleCytochrome P450 2C9enzyme
LansoprazoleCytochrome P450 3A4enzyme
LansoprazoleP-glycoprotein 1transporter
LansoprazoleATP-binding cassette sub-family G member 2transporter
LansoprazoleCytochrome P450 1A1enzyme
LansoprazoleCytochrome P450 1B1enzyme
LansoprazoleCytochrome P450 2C18enzyme
LansoprazoleCytochrome P450 2C8enzyme
LansoprazoleCytochrome P450 2D6enzyme
LansoprazoleMicrotubule-associated protein tautarget
LansoprazoleSolute carrier family 22 member 8transporter
LansoprazoleSolute carrier family 22 member 1transporter
LansoprazoleSolute carrier family 22 member 2transporter
LansoprazoleSolute carrier family 22 member 3transporter
EsomeprazolePotassium-transporting ATPase alpha chain 1target
EsomeprazoleCytochrome P450 2C19enzyme
EsomeprazoleCytochrome P450 3A4enzyme
EsomeprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
EsomeprazoleP-glycoprotein 1transporter
EsomeprazoleSolute carrier family 22 member 8transporter
RabeprazolePotassium-transporting ATPase alpha chain 1target
RabeprazoleCytochrome P450 3A4enzyme
RabeprazoleCytochrome P450 2C19enzyme
RabeprazoleATP-binding cassette sub-family G member 2transporter
RabeprazoleCytochrome P450 1A1enzyme
RabeprazoleCytochrome P450 1A2enzyme
RabeprazoleCytochrome P450 2C9enzyme
RabeprazoleCytochrome P450 2D6enzyme
RabeprazoleCytochrome P450 2C8enzyme
DexlansoprazolePotassium-transporting ATPase alpha chain 1target
DexlansoprazoleCytochrome P450 2C19enzyme
DexlansoprazoleCytochrome P450 3A4enzyme
DexlansoprazolePotassium-transporting ATPase subunit betatarget
DexlansoprazoleN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
DexrabeprazoleCytochrome P450 2C19enzyme
AluminiumSerotransferrintarget
AluminiumSodium/potassium-transporting ATPase subunit alpha-1target
AluminiumSerum albumincarrier
AluminiumKallikrein-1target
AluminiumAmyloid beta A4 proteintarget
Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 1transporter
Sodium bicarbonateSodium bicarbonate cotransporter 3transporter
Sodium bicarbonateElectroneutral sodium bicarbonate exchanger 1transporter
Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 4transporter
Sodium bicarbonateHydrogen ionstarget
Sodium bicarbonateSodium-driven chloride bicarbonate exchangertransporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
Aluminium phosphateSerotransferrintarget
Aluminium phosphateSodium/potassium-transporting ATPase subunit alpha-1target
Aluminium phosphateSerum albumincarrier
Aluminium phosphateKallikrein-1target
Aluminium phosphateAmyloid beta A4 proteintarget
RanitidineHistamine H2 receptortarget
RanitidineCytochrome P450 1A2enzyme
RanitidineCytochrome P450 2D6enzyme
RanitidineSolute carrier family 22 member 1transporter
RanitidineP-glycoprotein 1transporter
RanitidineSolute carrier family 22 member 8transporter
RanitidineCytochrome P450 3A4enzyme
RanitidineAcetylcholinesterasetarget
RanitidineSolute carrier family 22 member 2transporter
RanitidineAcetylcholinesteraseenzyme
FamotidineHistamine H2 receptortarget
FamotidineSolute carrier family 22 member 2transporter
FamotidineSolute carrier family 22 member 8transporter
FamotidineMultidrug and toxin extrusion protein 1transporter
FamotidineCytochrome P450 1A2enzyme
FamotidineSolute carrier family 22 member 6transporter
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
MethanthelineMuscarinic acetylcholine receptor M1target
MethanthelineHistamine H2 receptortarget
MethanthelineMuscarinic acetylcholine receptor M2target
MethanthelineMuscarinic acetylcholine receptor M3target
MethanthelineMuscarinic acetylcholine receptor M4target
MethanthelineMuscarinic acetylcholine receptor M5target
MethanthelineAcetylcholinesteraseenzyme
MetiamideHistamine H2 receptortarget
NizatidineHistamine H2 receptortarget
NizatidineP-glycoprotein 1transporter
NizatidineCholinesteraseenzyme
Roxatidine acetateHistamine H2 receptortarget
Sodium zirconium cyclosilicatePotassiumtarget