Almasilate is a buffering antacid that has been used in peptic ulcers and dyspepsia. It is a crystalline polyhydrate of aluminium/magnesium silicate and mediates its buffering activity by binding hydrogen... However its therapeutic efficacy is not comparable to other approved antacids, as it is no more effective in neutralizing acid and binding bile salts than other conventional antacids.
- Mechanism
- Curator reviewed · 4 references
Almasilate is a crystalline polyhydrate of aluminum/magnesium silicate and mediates its buffering activity by binding hydrogen ions within the polymer. Specifically, the aluminosilicate minerals dissolve, and in doing so consume acidic hydrogen ions and release moieties like H4SiO4, Al3+, and other cations, including the magnesium associated with the compound. Almasilate consequently contributes to the overall acid-neutralization by consuming acid hydrogen ion in this way. Additionally, aluminum and other metals released from the original compound may also accumulate into secondary aluminum and magnesium based antacid like products that can act as secondary pH buffers.
- Primary indication
- Almasilate is indicated for use as an antacid for the neutralization of excess stomach acid.Curator reviewed · 4 structured indications
- Formula / weight
- Al2H2MgO9Si2 · 280.445 g/mol (avg)
- Also known as
- Magnesium aluminosilicate hydrate
Resolves to
XFKLULFTFNRQOX-UHFFFAOYSA-NSMILESO.[Mg++].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-]What you can answer from here — as of March 06, 2025
Which other approved drugs treat the same conditions as Almasilate, and which companies have late-stage candidates in those indications?
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