Cytochrome P-450 CYP3A4 Substrates (strength unknown)
- Cytochrome P-450 CYP3A4 Substrates (strength unknown)
- Accession Number
Drug Drug Description Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Albendazole A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Cisapride A medication used to treat heartburn associated with GERD. Astemizole A second generation antihistamine used to treat allergy symptoms. Norethisterone A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Allylestrenol A steroid used to prevent premature labour in pregnant women. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Azithromycin A macrolide antibiotic used to treat a variety of bacterial infections. Cephalexin A first generation cephalosporin used to treat certain susceptible bacterial infections. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Prasterone A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy. Drospirenone A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions. Medical Cannabis The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical... Terfenadine An antihistamine for the treatment of allergy symptoms. Atazanavir An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Nintedanib A triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Ceritinib An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Netupitant An antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. Roflumilast A selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. Suvorexant A orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. Tasimelteon A melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder. Vorapaxar A platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Isavuconazole Indicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of... Cobimetinib An antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Dihydroergocryptine A dopamine agonist indicated in the treatment of cerebrovascular diseases and atherosclerosis. Dihydroergocornine A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Dihydroergocristine An ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Lacosamide An antiepileptic drug used to treat partial onset seizures in adults. Lomitapide A microsomal triglyceride transfer protein inhibitor used to lower cholesterol associated with homozygous familial hypercholesterolemia (HoFH), reducing risk of cardiovascular events such as myocardial infarction and stroke. Pranlukast A leukotriene receptor antagonist for the treatment of allergic rhinitis and asthma symptoms. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Ebastine A second generation H1-receptor antagonist useful in the treatment of allergic rhinitis and urticaria. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Duvelisib An inhibitor of phosphatidylinositol 3-kinase delta and gamma used to treat relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. 9-aminocamptothecin Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others. Methylprednisone Methylprednisone has been used in trials studying the treatment of Leukemia, Rheumatoid Arthritis, Renal Transplantation, Kidney Transplantation, and Acute Lymphocytic Leukemia, among others. St. John's Wort An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. Dacomitinib A medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution. Gilteritinib An AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. Vitamin D An ingredient found in a variety of supplements and vitamins. Doxazosin An alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Prucalopride A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation. Phentermine A sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Siponimod A medication used to treat relapsing multiple sclerosis. Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Alpelisib Alpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer.[Label] This cancer must be hormone receptor (HR)-positive, human epidermal growth factor... Pretomanid Part of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis. Lefamulin A pleuromutilin antibacterial used to treat community-acquired bacterial pneumonia (CABP). Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Elexacaftor A small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation. Tazemetostat A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. Umbralisib A kinase inhibitor used to treat rare forms of refractory lymphoma. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Estetrol An estrogen used in combination with drospirenone for oral contraception. Infigratinib An FGFR inhibitor used to treat locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) rearrangement.
- Drugs & Drug Targets