Cholinesterase substrates

Name
Cholinesterase substrates
Accession Number
DBCAT004572
Description

Not Available

Drugs
DrugDrug Description
CocaineAn ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.
SuccinylcholineA depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
TrimethaphanFor the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
ProcaineA local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.
TubocurarineTubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to...
BambuterolA long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm.
DipivefrinA prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.
ChloroprocaineA local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia.
ClevidipineA dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable.
CyclopentolateAn anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.
DoxacuriumA nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
OxybuprocaineA local anesthetic used in ophthalmology.
Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
MirabegronA beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity.
AclidiniumAn inhaled long-acting anticholinergic used as a maintenance bronchodilator in patients with chronic obstructive pulmonary disease (COPD).
IrinotecanAn antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum.
MoxisylyteBy the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either by...
PropacetamolPropacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.
ButambenAnesthesia of mucus membranes other than the eyes.
ButyrylthiocholineA sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem]
BenzonatateA non-narcotic oral antitussive drug used to suppress coughing.
PyridostigmineA cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants.
Drugs & Drug Targets
DrugTargetType
CocaineSodium-dependent noradrenaline transportertarget
CocaineSodium channel proteintarget
CocaineSodium-dependent serotonin transportertarget
CocaineSodium-dependent dopamine transportertarget
CocaineCytochrome P450 3A4enzyme
CocaineMuscarinic acetylcholine receptor M1target
CocaineMuscarinic acetylcholine receptor M2target
CocaineCytochrome P450 2D6enzyme
CocaineSolute carrier family 22 member 2transporter
CocaineCytochrome P450 2C8enzyme
CocaineSigma non-opioid intracellular receptor 1target
CocaineLiver carboxylesterase 1target
CocaineCholinesteraseenzyme
CocaineSodium-dependent dopamine transportertransporter
Cocainealpha1-acid glycoproteincarrier
CocaineLiver carboxylesterase 1enzyme
SuccinylcholineCholinesteraseenzyme
SuccinylcholineMuscarinic acetylcholine receptor M2target
SuccinylcholineMuscarinic acetylcholine receptor M3target
SuccinylcholineNeuronal Acetylcholine (nACh) Receptor Subunitstarget
TrimethaphanNeuronal acetylcholine receptor subunit alpha-10target
TrimethaphanCholinesteraseenzyme
ProcaineSodium channel protein type 10 subunit alphatarget
ProcaineGlutamate receptor ionotropic, NMDA 3Atarget
Procaine5-hydroxytryptamine receptor 3Atarget
ProcaineSodium-dependent dopamine transportertarget
ProcaineNeuronal acetylcholine receptor subunit alpha-2target
ProcaineCholinesteraseenzyme
ProcaineDNA (cytosine-5)-methyltransferase 1target
ProcaineCalcium-activated potassium channeltarget
ProcaineCytosolic phospholipase A2target
Procaine60 kDa lysophospholipasetarget
ProcaineMonoamine oxidasetarget
ProcaineSodium-dependent dopamine transportertransporter
ProcaineSodium-dependent noradrenaline transportertransporter
ProcaineSodium-dependent serotonin transportertransporter
ProcaineDNA (cytosine-5)-methyltransferase 3Atarget
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
BambuterolBeta-2 adrenergic receptortarget
BambuterolCholinesteraseenzyme
DipivefrinAlpha-2A adrenergic receptortarget
DipivefrinCholinesterasetarget
DipivefrinBeta-2 adrenergic receptortarget
DipivefrinAlpha-1A adrenergic receptortarget
DipivefrinAcetylcholinesterasetarget
ChloroprocaineSodium channel protein type 10 subunit alphatarget
ChloroprocaineSodium-dependent dopamine transportertarget
ChloroprocaineCholinesteraseenzyme
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
ClevidipineCytochrome P450 2C9enzyme
ClevidipineCytochrome P450 2D6enzyme
ClevidipineCytochrome P450 2E1enzyme
ClevidipineCytochrome P450 2C19enzyme
ClevidipineCytochrome P450 3A4enzyme
ClevidipineCholinesteraseenzyme
CyclopentolateMuscarinic acetylcholine receptor M1target
CyclopentolateCholinesteraseenzyme
DoxacuriumNeuronal acetylcholine receptor subunit alpha-2target
DoxacuriumMuscarinic acetylcholine receptor M2target
DoxacuriumCholinesteraseenzyme
EphedrineAlpha-1A adrenergic receptortarget
EphedrineSodium-dependent noradrenaline transportertarget
EphedrineCholinesteraseenzyme
EphedrineSerum albumincarrier
EphedrineBeta-1 adrenergic receptortarget
EphedrineBeta-2 adrenergic receptortarget
EphedrineSynaptic vesicular amine transportertransporter
EphedrineAcetylcholinesteraseenzyme
OxybuprocaineSodium channel protein type 10 subunit alphatarget
OxybuprocaineCholinesteraseenzyme
Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
Sar9, Met (O2)11-Substance PCholinesteraseenzyme
Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme
MirabegronCytochrome P450 3A4enzyme
MirabegronCytochrome P450 2D6enzyme
MirabegronP-glycoprotein 1transporter
MirabegronSolute carrier organic anion transporter family member 1A2transporter
MirabegronSerum albumincarrier
MirabegronAlpha-1-acid glycoprotein 1carrier
MirabegronCholinesteraseenzyme
MirabegronBeta-3 adrenergic receptortarget
MirabegronUDP-glucuronosyltransferase 2B7enzyme
MirabegronUDP-glucuronosyltransferase 1-3enzyme
MirabegronUDP-glucuronosyltransferase 1-8enzyme
MirabegronSolute carrier family 22 member 1transporter
MirabegronSolute carrier family 22 member 2transporter
MirabegronSolute carrier family 22 member 3transporter
MirabegronBeta-1 adrenergic receptortarget
AclidiniumMuscarinic acetylcholine receptor M1target
AclidiniumMuscarinic acetylcholine receptor M2target
AclidiniumMuscarinic acetylcholine receptor M3target
AclidiniumMuscarinic acetylcholine receptor M4target
AclidiniumMuscarinic acetylcholine receptor M5target
AclidiniumCholinesteraseenzyme
IrinotecanDNA topoisomerase I, mitochondrialtarget
IrinotecanDNA topoisomerase 1target
IrinotecanCytochrome P450 3A4enzyme
IrinotecanCytochrome P450 3A5enzyme
IrinotecanUDP-glucuronosyltransferase 1-1enzyme
IrinotecanUDP-glucuronosyltransferase 1-9enzyme
IrinotecanLiver carboxylesterase 1enzyme
IrinotecanCytochrome P450 3A7enzyme
IrinotecanCytochrome P450 2B6enzyme
IrinotecanSolute carrier family 22 member 3transporter
IrinotecanSolute carrier organic anion transporter family member 1B1transporter
IrinotecanMultidrug resistance-associated protein 1transporter
IrinotecanATP-binding cassette sub-family G member 2transporter
IrinotecanSerum albumincarrier
IrinotecanCocaine esteraseenzyme
IrinotecanCholinesteraseenzyme
IrinotecanP-glycoprotein 1transporter
IrinotecanCanalicular multispecific organic anion transporter 1transporter
MoxisylyteCholinesteraseenzyme
MoxisylyteCytochrome P450 3A Subfamilyenzyme
MoxisylyteAlpha adrenergic receptortarget
PropacetamolCholinesteraseenzyme
PropacetamolProstaglandin G/H synthase 1target
PropacetamolProstaglandin G/H synthase 2target
PropacetamolTransient receptor potential cation channel subfamily V member 1target
PropacetamolCannabinoid receptor 1target
PropacetamolCytochrome P450 2E1enzyme
PropacetamolCytochrome P450 1A2enzyme
PropacetamolCytochrome P450 2D6enzyme
PropacetamolUDP-glucuronosyltransferase 1-1enzyme
PropacetamolUDP-glucuronosyltransferase 1-6enzyme
PropacetamolUDP-glucuronosyltransferase 1-9enzyme
PropacetamolUDP-glucuronosyltransferase 2B15enzyme
PropacetamolUDP-glucuronosyltransferase 1-10enzyme
PropacetamolSulfotransferase 1A1enzyme
PropacetamolSulfotransferase 1A3/1A4enzyme
PropacetamolEstrogen sulfotransferaseenzyme
PropacetamolBile salt sulfotransferaseenzyme
PropacetamolArylamine N-acetyltransferase 2enzyme
PropacetamolCytochrome P450 2C9enzyme
PropacetamolCytochrome P450 3A4enzyme
ButambenVoltage-dependent calcium channeltarget
ButambenCholinesteraseenzyme
ButambenAlpha-1-acid glycoprotein 1carrier
ButambenSerum albumincarrier
ButambenATP-sensitive potassium channeltarget
ButambenTransient receptor potential cation channel subfamily A member 1target
ButambenTransient receptor potential cation channel subfamily V member 4target
ButyrylthiocholineCholinesterasetarget
ButyrylthiocholineCholinesteraseenzyme
BenzonatateSodium channel protein type 5 subunit alphatarget
BenzonatateCholinesteraseenzyme
PyridostigmineAcetylcholinesterasetarget
PyridostigmineCholinesterasetarget
PyridostigmineAcetylcholinesteraseenzyme
PyridostigmineCholinesteraseenzyme
PyridostigmineCytochrome P450 3A4enzyme