Sunburn (DBCOND0005372)

Identifiers

Synonyms

Sunburn, unspecified / Solar sensitiveness / Solar erythema / Solar erythema (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amiloxate	Indicated as an active sunscreen agent.	No drug targets
Avobenzone	A sunscreen agent found in sunscreens that absorbs UV rays.	No drug targets
Bemotrizinol	An ingredient used in sunscreen to block UVA and UVB radiation.	No drug targets
Benzocaine	A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.	Sodium channel protein type 10 subunit alphatarget ATP-dependent translocase ABCB1transporter Liver carboxylesterase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Albumincarrier alpha1-acid glycoproteincarrier
Benzophenone	An ingredient used in sunscreens to absorb UV radiation.	Estrogen receptortarget Estrogen receptor betatarget
Benzyl alcohol	An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older.	Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Aldehyde dehydrogenase, mitochondrialenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme
Bisoctrizole	An absorber of UVA and UVB radiation used in sunscreen.	No drug targets
Camphor	A compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.	Camphor 5-monooxygenasetarget Transient receptor potential cation channel subfamily V member 1target Transient receptor potential cation channel subfamily V member 3target Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target
Chlorphenoxamine	An antihistamine used as an antipruritic.	No drug targets
Dexchlorpheniramine	A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin.	Cytochrome P450 2D6enzyme
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Diethylamino hydroxybenzoyl hexyl benzoate	Indicated for use as a sunscreen agent.	No drug targets
Diethyltoluamide	An insect repellant, also known as DEET.	No drug targets
Dioxybenzone	A benzophenone derivative used in sunscreens to block UVB and short-wave UVA radiation.	Sex hormone-binding globulintarget Alpha-fetoproteincarrier
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Drometrizole trisiloxane	An UV ray absorbing agent used in sunscreens to protect skin from UV radiation.	No drug targets
Ecamsule	A sunscreen agent found in sunscreens that absorbs UV rays.	No drug targets
Ethanol	For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...	Gamma-aminobutyric acid receptor subunit alpha-1target Glutamate receptor ionotropic, NMDA 3Atarget Glycine receptor subunit alpha-1target Glycine receptor subunit alpha-2target Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 4A11enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme Alcohol dehydrogenase 1Cenzyme Alcohol dehydrogenase class-3enzyme Voltage-dependent L-type calcium channel subunit beta-1target 5-hydroxytryptamine receptor 3Atarget All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Gamma-aminobutyric acid receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-10target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Gamma-aminobutyric acid receptor subunit alpha-5target Gamma-aminobutyric acid receptor subunit alpha-4target All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme Gamma-aminobutyric acid receptor subunit alpha-3target Glutamate receptor 1target Voltage-dependent calcium channel gamma-1 subunittarget Neuronal acetylcholine receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-6target Glutamate receptor 2target Glutamate receptor 4target Glutamate receptor 3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target G protein-activated inward rectifier potassium channel 1target G protein-activated inward rectifier potassium channel 2target Vascular cell adhesion protein 1target Equilibrative nucleoside transporter 1target G protein-activated inward rectifier potassium channel 4target Neuronal acetylcholine receptor subunit alpha-7target Neuronal acetylcholine receptor subunit alpha-9target Gamma-aminobutyric acid receptor subunit beta-1target Gamma-aminobutyric acid receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit beta-2target Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Alcohol dehydrogenase 6enzyme Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-5target Neuronal acetylcholine receptor subunit alpha-6target Neuronal acetylcholine receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit gamma-1target Gamma-aminobutyric acid receptor subunit gamma-3target Gamma-aminobutyric acid receptor subunit epsilontarget Gamma-aminobutyric acid receptor subunit pitarget Gamma-aminobutyric acid receptor subunit thetatarget Gamma-aminobutyric acid receptor subunit deltatarget Aldo-keto reductase family 1 member A1enzyme Equilibrative nucleoside transporter 2target 5-hydroxytryptamine receptor 3Etarget 5-hydroxytryptamine receptor 3Btarget 5-hydroxytryptamine receptor 3Dtarget 5-hydroxytryptamine receptor 3Ctarget Voltage-dependent calcium channel gamma-2 subunittarget G protein-activated inward rectifier potassium channel 3target Neural cell adhesion molecule L1target Acetylcholinesterasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target
Ethylhexyl methoxycrylene	Ethylhexyl methoxycrylene is employed as a photostabilizing agent in various sunscreen products .	No drug targets
Homosalate	As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.	Progesterone receptortarget Androgen receptortarget Estrogen receptortarget
Lidocaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Epidermal growth factor receptortarget Sodium channel protein type 9 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Sodium channel protein type 4 subunit alphatarget Alpha-1-acid glycoprotein 1target Alpha-1-acid glycoprotein 2target Sodium channel protein type 11 subunit alphatarget
Malic acid	Malic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.	No drug targets
Octinoxate	A sunscreen agent found in sunscreens that absorbs UV rays.	No drug targets
Octisalate	Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.	No drug targets
Octocrylene	A sunscreen agent found in sunscreens that absorbs UV rays.	Estrogen receptortarget Estrogen receptor betatarget
Oxybenzone	A sunscreen agent found in sunscreens that absorbs UV rays.	Progesterone receptortarget Androgen receptortarget Estrogen receptortarget Estrogen receptor betatarget Hormone-sensitive lipasetarget
Peg-100 stearate	Not Annotated	No drug targets
Pheniramine	An antihistamine used to treat allergic rhinitis and pruritus.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Histamine H4 receptortarget
Polysilicone-15	Polysilicone-15 is used as an UV-filter in cosmetic sunscreen products as well as in other cosmetic products (like shampoos, conditioners, hairsprays, etc.) where it can confer photostability to the product(s)...	No drug targets
Tetracaine	A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.	Ryanodine receptor 1target Ryanodine receptor 2target Voltage-gated sodium channel alpha subunittarget Sodium channel protein type 10 subunit alphatarget
Titanium dioxide	A sunscreen agent found in sunscreens that absorbs UV rays.	Macrophage receptor MARCOtarget
Urea	A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.	Arginase-1target Carbonic anhydrase 2target Catenin beta-1target Sulfoxide reductase catalytic subunit YedYtarget Urea transporter 2transporter Urea transporter 1transporter Dihydrofolate reductasetarget
Zinc	An essential element commonly used for the treatment of patients with documented zinc deficiency.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Programmed cell death protein 6target DAN domain family member 5target Metallothionein-1Atarget Alpha-1B-glycoproteintarget Alpha-2-macroglobulintarget Angiotensinogentarget Alpha-2-HS-glycoproteintarget Serum amyloid P-componenttarget Apolipoprotein A-Itarget Apolipoprotein A-IItarget Apolipoprotein A-IVtarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement component C8 alpha chaintarget Complement component C8 beta chaintarget Complement component C8 gamma chaintarget Complement factor Btarget Complement factor Htarget Complement factor Itarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Desmoplakintarget Coagulation factor XIItarget Coagulation factor XIII B chaintarget Prothrombintarget Ficolin-3target Fibrinogen alpha chaintarget Fibronectintarget Gelsolintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobin-related proteintarget Hornerintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Immunoglobulin heavy constant alpha 1target Immunoglobulin heavy constant mutarget Immunoglobulin kappa variable 1-17target Immunoglobulin kappa variable 3-20target Immunoglobulin lambda variable 3-21target Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Junction plakoglobintarget Plasma kallikreintarget Kininogen-1target Keratin, type II cytoskeletal 1target Keratin, type I cytoskeletal 10target Keratin, type I cytoskeletal 14target Keratin, type I cytoskeletal 16target Keratin, type II cytoskeletal 2 epidermaltarget Keratin, type II cytoskeletal 5target Keratin, type II cytoskeletal 6Atarget Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Kallistatintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carbonic anhydrase 1enzyme
Zinc oxide	A mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06651476	A Randomized Controlled Trial to Test Whether Oxytocin Amplifies the Effect of Vibration to Increase Heat Pain Threshold After UV-B Burn	No drug interventions	basic_science	2	not_yet_recruiting
NCT01085851	Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms	Dexchlorpheniramine	treatment	3	unknown_status
NCT03607578	Test of Interventions to Prevent Skin Cancer Among Danes on Vacation in High UV Index Sunny Destinations	No drug interventions	prevention	Not Available	completed
NCT03489356	Project Options - The ABC Method	No drug interventions	prevention	Not Available	completed
NCT05260359	Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol	Avobenzone Bemotrizinol Octinoxate Octocrylene Oxybenzone Petrolatum	screening	2	completed
NCT03752736	Sun Safety Skills for Elementary School Students	No drug interventions	prevention	Not Available	completed
NCT03199573	Hats on Head Start: A A Survey of Sun Protection Behaviors in Head Start and Other Early Childhood Education Programs	No drug interventions	Not Available	Not Available	completed
NCT05767008	Water Immersion Studies of a Long-wear Sunscreen to Improve Protection Against Ultraviolet Radiation	No drug interventions	prevention	Not Available	completed
NCT01021787	Dermal Penetration of the Titanium Dioxide in Anthelios SX SPF40 Cream	Titanium dioxide	Not Available	4	completed
NCT00441051	Efficacy and Safety of Diclofenac Sodium (0.1%) Gel in Patients With UV Induced Painful Sunburn	Diclofenac	treatment	3	completed
NCT03332524	Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn	Chlorpheniramine Ibuprofen	treatment	2	terminated
NCT01237925	Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms	Dexchlorpheniramine	treatment	3	unknown_status
NCT01873430	The Sun Protective Effect of Melatonin	Melatonin	prevention	1	completed
NCT00326274	Clinical Safety Trial of Long-Term Intermittent Use of Helioblock® SX Cream	No drug interventions	Not Available	3	completed
NCT00206882	The Sun Protection Effect and Efficacy in Treatment of Sunburn Using Topical Corticosteroids.	No drug interventions	treatment	Not Available	unknown_status
NCT03007589	Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics	No drug interventions	prevention	Not Available	enrolling_by_invitation