Sinusitis (DBCOND0014061)

Identifiers

Synonyms
Highmoritis / Sinusitis (disorder) / Sinus infection / Sinusitis NOS / Chronic sinusitis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acetaminophen
An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
Acetylcysteine
A medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
Amoxicillin
A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
Chlorpheniramine
A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
Clavulanic acid
A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.
Clonazoline
Not Annotated
No drug targets
Dexpanthenol
An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).
No drug targets
Dimetindene
A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
Mometasone
A corticosteroid with no indications.
Morniflumate
An NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems.
Moxifloxacin
A fluoroquinolone antibiotic used to treat various bacterial infections.
Naphazoline
A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
Naproxen
An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
Oxolamine
A medication indicated in the treatment of a cough or upper respiratory tract inflammation.
No drug targets
Phenylephrine
An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
Pholcodine
An opioid antitussive used to suppress unproductive coughing.
Pseudoephedrine
An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
Silver proteinate
A nasal decongestant and antiseptic of the nasal and ear canals.
No drug targets
Sodium chloride
An ingredient found in a variety of nutritional products as a source of electrolytes and water.
No drug targets
Tetryzoline
An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
Xylometazoline
A direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06639295
A Study to Evaluate 611 in Patients with Chronic Rhinosinusitis with Nasal PolypsNo drug interventionstreatment3not_yet_recruiting
NCT06023550
Complicated Infections in OtorhinolaryngologyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06603935
Harnessing Digital Medicine to Improve Allergic Rhinitis Management in Primary Care (DMAR)No drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT03102190
Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polypstreatment1terminated
NCT00970190
Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03943121
The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal PolypsNo drug interventionstreatmentNot Availableunknown_status
NCT00739921
The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNANo drug interventionsdiagnosticNot Availablecompleted
NCT03783702
Pain Control Following Sinus Surgerytreatment4completed
NCT01485484
Development and Validation of a NIRS-based Sinusitis ScreeningNo drug interventionsNot AvailableNot Availablecompleted
NCT02278484
Sinus Balloon Dilation in Pediatric PatientsNo drug interventionstreatmentNot Availablecompleted
NCT06498843
Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections/ConditionsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03229551
Xylitol for Chronic Sinusitistreatment2 / 3completed
NCT00747747
Sinuclean's Treatment Of Sinusitis' SymptomsNo drug interventionstreatment4completed
NCT00543998
Near Infrared Transillumination of the Paranasal SinusesNo drug interventionsNot AvailableNot Availablecompleted
NCT00896883
Evaluation of the Middle Turbinate Implant for Affixing the Middle Turbinate to the Nasal SeptumNo drug interventionspreventionNot Availablecompleted
NCT02554383
Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?treatment3completed
NCT00545961
Middle Meatal Bacteriology During Acute Respiratory Infection in Childrentreatment4unknown_status
NCT02221128
PerClot to Control Bleeding in Endoscopic Sinus SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT01350193
Manuka Honey Irrigation After Sinus SurgeryNo drug interventionstreatment1 / 2completed
NCT06089278
A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps.No drug interventionstreatment2recruiting
NCT00705237
Study of the Use of LUMA LightwireNo drug interventionssupportive_care4terminated
NCT03011632
Response of the Airway in Sinusitis and Asthmatreatment4completed
NCT01155752
Pulmozyme in Cystic Fibrosis With Sinusitistreatment3withdrawn
NCT02340000
Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanatetreatment4completed
NCT00132275
Guidelines for Acute SinusitistreatmentNot Availablecompleted
NCT01564849
The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic RhinosinusitisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02933918
Safety of Intranasal Irrigation Probiotics in Healthy VolunteersNo drug interventionstreatmentNot Availablecompleted
NCT02367118
Prednisone in Chronic Rhinosinusitis Without Nasal Polypstreatment3unknown_status
NCT05049434
Efficacy and Safety for Medicurtain® in Prevention of Adhesion After Endoscopic Sinus Surgery (Pivotal Study)No drug interventionspreventionNot Availablecompleted
NCT03374124
The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic RhinosinusitisNo drug interventionsNot AvailableNot Availableunknown_status
NCT00492024
BAY12-8039: 5 Days for Sinusitis vs Placebotreatment3completed
NCT04241016
Endoscopic Sinus Surgery in Recurrent Acute RhinosinusitisNo drug interventionstreatmentNot Availablerecruiting
NCT03729258
Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.treatment3recruiting
NCT03535558
Fluoroquinolone Associated DisabilityNot AvailableNot Availablecompleted
NCT06016335
MRI-based Synthetic CT Images of the Head and NeckNo drug interventionsdiagnosticNot Availablecompleted
NCT03036735
Rates of Middle Meatus Synechiae Formation Post ESSNo drug interventionstreatmentNot Availableterminated
NCT00236522
A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.treatment3completed
NCT02413125
Comparison of Nasal Saline Irrigation Bottle Contamination Between Two SolutionsNo drug interventionstreatmentNot Availableunknown_status
NCT01248325
A Study of Luffa Operculate Nasal Solution 5mg/mL Compared With Saline (NaCl 09%) for the Relief of Nasal ObstructionNo drug interventionstreatment3unknown_status
NCT00465530
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in ChildrenNo drug interventionstreatmentNot Availablecompleted
NCT03390257
Study to Evaluate the Safety and Initial Effectiveness of the Sinusway™ for Endoscopy of Sinuses in Conjunction With BSDNo drug interventionsdiagnosticNot Availablecompleted
NCT01050465
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic UseNo drug interventionsNot AvailableNot Availablecompleted
NCT01717274
Hot Saline Irrigation StudyNo drug interventionssupportive_careNot Availablecompleted
NCT03256773
High Resolution Micro OCT ImagingNo drug interventionsNot AvailableNot Availablerecruiting
NCT00245427
Outcomes of Patients Not Responding to Antibiotics in the CommunityNo drug interventionsNot AvailableNot Availablecompleted
NCT00423176
The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusitis When Used With Antibiotics (Study P04824AM3)No drug interventionstreatment3terminated
NCT00355160
Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT02900794
Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus SurgeryNo drug interventionstreatmentNot Availablewithdrawn
NCT00174694
CHOOSE : Telithromycin, Acute Bacterial Sinusitistreatment4completed
NCT00645762
Balloon REmodeling Antrostomy THErapy StudyNo drug interventionstreatment2completed
NCT02194062
Comparison of Nasal Steroids After FESS in CRSwNPtreatmentNot Availablecompleted
NCT01612780
Trans-Nasal Maxillary Multi-Sinus Balloon Dilation StudyNo drug interventionstreatmentNot Availablecompleted
NCT01685229
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic RhinosinusitisNo drug interventionsNot AvailableNot Availablecompleted
NCT02079792
The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization DeviceNo drug interventionstreatment4completed
NCT02071667
Association of Periostin Levels and Chronic SinusitisNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01907204
Evaluation of Inhaled Treatment in Sinusitistreatment2 / 3completed
NCT02191046
Effect of Squeezable Bottle Nasal Irrigation Device in Children With SinusitisNo drug interventionstreatmentNot Availablecompleted
NCT00517946
A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.Not AvailableNot Availablecompleted
NCT01118312
Study of Asthma and Nasal Steroidstreatment4completed
NCT02975310
In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal PolypsNo drug interventionstreatmentNot Availablerecruiting
NCT00803881
Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to SmellNo drug interventionsNot AvailableNot Availableunknown_status
NCT01623050
Safety and Performance of the SinuSys Dilation System for Dilation of the Maxillary Sinus OstiumNo drug interventionstreatment1completed
NCT00368823
A Trial of Point of Care Information in Ambulatory PediatricsNo drug interventionstreatment3completed
NCT02454608
Trial of Verapamil in Chronic RhinosinusitistreatmentNot Availableterminated
NCT01825408
Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitistreatment4completed
NCT00493038
Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitistreatment4terminated
NCT04841343
Triamcinolone Packing Following Endoscopic Sinus SurgeryNot AvailableNot Availablecompleted
NCT02924103
Contamination Free Bacterial SwapNo drug interventionsdiagnosticNot Availablecompleted
NCT06495021
How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care.No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02502084
Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal SinusesNo drug interventionsdiagnosticNot Availablecompleted
NCT01107379
Optimization and Refinement of Technique in In-Office Sinus Dilation 2No drug interventionsNot AvailableNot Availablecompleted
NCT02463279
SinuSys Patency of Frontal Recess and Sphenoid Sinus Ostia StudyNo drug interventionstreatmentNot Availablecompleted
NCT00232154
A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up ToNot Available2completed
NCT02110654
Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgerytreatment4completed
NCT00705354
Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus SurgerytreatmentNot Availablewithdrawn
NCT05301777
Computed Tomography Anatomy of the Paranasal Sinuses and Anatomical Variants of Clinical Relevants in Egyptian Adults .No drug interventionsNot AvailableNot Availableunknown_status
NCT01166945
Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in ChildrentreatmentNot Availablecompleted
NCT01671098
Sinonasal Gas Exchange DynamicsNo drug interventionsNot AvailableNot Availablecompleted
NCT01906697
The Effect of RF Turbinoplasty in Polypoid Change of Middle TurbinatesNo drug interventionstreatment3unknown_status
NCT05924711
"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".No drug interventionsNot AvailableNot Availablerecruiting
NCT00117611
Xolair in Patients With Chronic SinusitisNo drug interventionstreatment4completed
NCT01919411
Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trialtreatment4completed
NCT01420471
Medicated Punctured-Glove-Finger Spacer Studytreatment4completed
NCT03584178
The Long-Term Safety of Budesonide for Patients With Chronic RhinosinusitisNo drug interventionssupportive_careNot Availableunknown_status
NCT05126407
A Study of Olynth Saline/Ectomed Nasal Drops/Spray Based Upon Previous UsageNo drug interventionsNot AvailableNot Availablecompleted
NCT03454607
Foot Controlled Robotic Endoscope Enabled Robot FESSNo drug interventionsotherNot Availableterminated
NCT01115309
XprESS Registry StudyNo drug interventionstreatmentNot Availablecompleted
NCT00335309
Maxillary Sinus Irrigation in the Management of Chronic RhinosinusitistreatmentNot Availablecompleted
NCT04678856
Dupilumab in CRSsNPtreatment2completed
NCT00944515
Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in ChildrenpreventionNot Availablecompleted
NCT00242437
Hemostatic Matrix in Endoscopic Sinus SurgeryNo drug interventionseducational_counseling_training4completed
NCT00000752
Preventing Frequent Sinus Infections in HIV-Infected Patientstreatment2withdrawn
NCT02407275
Rhinosinusites ChroniquesNo drug interventionsscreeningNot Availableunknown_status
NCT01033799
Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workersNo drug interventionsbasic_scienceNot Availablecompleted
NCT02533206
Pilot Study of The EPIC TrialNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00002149
Acupuncture and Herbal Treatment of Chronic HIV SinusitistreatmentNot Availablecompleted
NCT01315418
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor SituationNo drug interventionsbasic_scienceNot Availableterminated
NCT01814618
Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgerytreatment2withdrawn
NCT02927834
Oral Steroids in Chronic Rhinosinusitis Without Nasal PolypstreatmentNot Availablecompleted
NCT00791934
Clinical Study of Safety and Efficacy for the Relieva Stratus With Elution of Triamcinolone AcetonideNo drug interventionstreatmentNot Availablecompleted
NCT00588016
Concentration of Itraconazole Solution in Nasal Secretionstreatment1completed
NCT05865496
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal PolypsNo drug interventionstreatment2active_not_recruiting
NCT01001039
Validation of the Facial and Cephalic Pain InventoryNo drug interventionsNot AvailableNot Availablecompleted
NCT02077322
Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus SurgeryNo drug interventionspreventionNot Availablecompleted
NCT00934830
Antibiotics Versus Therapeutic Ultrasound for Sinusitistreatment3completed
NCT02506426
Endoscopic Sinus Surgery for Refractory Chronic SinusitisNo drug interventionstreatmentNot Availableunknown_status
NCT01255566
Medical Therapy Versus Sinus Surgery for Chronic Rhinosinusitis: A Prospective, Multi-institutional StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00208065
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fiberstreatment4completed
NCT01129765
Home Usability of a Nasal Lavage System in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00266474
Prevalence of Chronic Rhinosinusitis in Cystic FibrosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00367120
Zmax Compared to Augmentin in Sinusitistreatment4completed
NCT06182982
Auriculotherapy for Intraoperative Blood Pressure ControlNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00416182
Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosistreatment2completed
NCT02855931
Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal PolypsNo drug interventionstreatmentNot Availablecompleted
NCT02627794
Rates of Middle Meatus Synechiae Formation Post Endoscopic Sinus SurgeryNo drug interventionsprevention3terminated
NCT01684540
Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute RhinosinusitisNo drug interventionsNot AvailableNot Availablecompleted
NCT01442740
15-Degree Tilt, Head Up, Feet Down Body Position for Sinus Surgery PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT01156701
Prophylactic Efficacy of Relenza Against Influenza A and BNot AvailableNot Availablecompleted
NCT02931604
Study Designed to Clinically Evaluate Sinus Wash Device PrototypesNo drug interventionstreatmentNot Availableunknown_status
NCT02630472
Topical Irrigation Therapy for CRStreatment1 / 2terminated
NCT00534768
Postoperative Treatment After Endoscopic Sinus SurgeryNo drug interventionstreatmentNot Availablecompleted
NCT01492868
Sinusitis in Children and the Nasopharyngeal MicrobiomeNo drug interventionsNot AvailableNot Availablecompleted
NCT02799446
Effect of Reslizumab in Chronic Rhinosinusitistreatment3unknown_status
NCT00249210
A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinusestreatment3completed
NCT05390255
Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitistreatment3recruiting
NCT00634608
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice WorkflowNo drug interventionsNot AvailableNot Availablecompleted
NCT00004638
Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in ChildrenNo drug interventionsdiagnosticNot Availablecompleted