Metabolic Acidosis (DBCOND0043658)

Identifiers

Synonyms
Acidosis, Metabolic / Metabolic acidosis / Acidosis, unspecified / Acidosis metabolic / Metabolic acidosis (disorder) / Metabolic acidosis NOS

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Citric acid
An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.
Potassium bicarbonate
An ingredient used as an antacid or to treat hypokalemia.
Potassium chloride
A potassium salt used to treat hypokalemia.
Potassium citrate
An agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
No drug targets
Pyridoxine
A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
Sodium bicarbonate
A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
Sodium chloride
An ingredient found in a variety of nutritional products as a source of electrolytes and water.
No drug targets
Sodium citrate
An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Tromethamine
A proton acceptor used for the prevention and correction of metabolic acidosis associated with various clinical conditions, such as cardiac bypass surgery.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03537898
Balanced Solutions and Plasma ElectrolytesNo drug interventionstreatmentNot Availablecompleted
NCT05113641
Reducing Dietary Acid with Food Versus Oral Alkali in People with Chronic Kidney Disease (ReDACKD)treatmentNot Availablerecruiting
NCT05697770
SODium BICarbonate for Metabolic Acidosis in the ICUtreatment3recruiting
NCT01295190
Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary BypassNo drug interventionsNot AvailableNot Availablecompleted
NCT03428464
Bicarbonate Administration in Kidney Transplant RecipientstreatmentNot Availablecompleted
NCT05259202
Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart RateNo drug interventionsNot AvailableNot Availableunknown_status
NCT05147051
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill PatientsNo drug interventionstreatment2completed
NCT04727528
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Diseasetreatment3terminated
NCT01777178
Comparison of Standard Versus Low Bicarbonate HemodialysisNo drug interventionstreatment1completed
NCT03354507
Use of Sodium Bicarbonate in Patients Treated With TopiramateNo drug interventionstreatmentNot Availableunknown_status
NCT04975906
The Threshold of Serum Anion Gap as a Screening Tool for Organic AcidosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05582824
Lactate Metabolism in the Hypoperfused Critically IllNo drug interventionsNot AvailableNot Availableunknown_status
NCT00913796
Metabolic Acidosis in Renal Transplant Patientstreatment2completed
NCT04010630
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICUotherNot Availablecompleted
NCT02303548
Bicarbonate in Patients With Out-of-hospital Cardiac Arresttreatment2completed
NCT04984226
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKDprevention2recruiting
NCT01293266
Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart CatheterisationscreeningNot Availablecompleted
NCT06545565
Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutritionother3recruiting
NCT05970094
Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5No drug interventionstreatmentNot Availablecompleted
NCT02915601
Bicarbonate Administration in CKDtreatmentNot Availablecompleted
NCT01452412
Alkali Therapy in Chronic Kidney Diseasetreatment2 / 3completed
NCT01075750
Perioperative Fluid Management in Patients Receiving Cadaveric Renal TransplantsNo drug interventionsNot AvailableNot Availablecompleted
NCT02476253
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Illtreatment3completed
NCT05005793
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipientstreatment4recruiting
NCT02098356
Comparison of High Versus Low Bicarbonate HemodialysisNo drug interventionstreatmentNot Availablecompleted
NCT06327737
Diabetic Ketoacidosis Diagnosis and ManagementNo drug interventionsNot AvailableNot Availablecompleted
NCT02031770
Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney DiseasetreatmentNot Availablecompleted
NCT03390842
Long-term Safety Extension to Study TRCA-301treatment3completed
NCT01640119
Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD)No drug interventionsprevention3unknown_status
NCT03846258
High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement TherapyNo drug interventionstreatment4withdrawn
NCT01506258
Autologous Stem Cells in Newborns With Oxygen DeprivationNo drug interventionspreventionNot Availableunknown_status
NCT05940935
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy OperationsNo drug interventionsNot AvailableNot Availablecompleted
NCT06366230
Adding Urea to the Final Dialysis Fluidtreatment1 / 2not_yet_recruiting
NCT01894594
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Diseasetreatment1terminated
NCT03710291
Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosistreatment3terminated
NCT05784389
Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5No drug interventionstreatmentNot Availablerecruiting
NCT03317444
Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Diseasetreatment3completed
NCT01860001
Incidence of Postoperative Ketosis and Metabolic AcidosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03897101
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)No drug interventionsNot AvailableNot Availableunknown_status
NCT04229069
Acid-Base Balance, Metabolism and MineralsNo drug interventionstreatmentNot Availablecompleted
NCT05842369
ADVOSĀ® Versus CVVHD in Metabolic or Mixed AcidosisNo drug interventionstreatmentNot Availablerecruiting
NCT03035812
Alkalinization by Urologists & Nephrologiststreatment4completed
NCT06237712
Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.No drug interventionstreatmentNot Availableenrolling_by_invitation
NCT04600323
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKDtreatment0completed
NCT02800343
Intraoperative Cell Salvage and Postoperative AcidosisNo drug interventionsNot AvailableNot Availablecompleted