Sprains (DBCOND0044425)

Identifiers

Synonyms

Sprain / Sprain (morphologic abnormality) / Ligament sprain / Sprain of ligament (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
(+)-menthol	Not Annotated	No drug targets
(S)-camphor	Indicated for the temporary symptomatic relief of minor aches and pains of muscles and joints in topical analgesics.	Transient receptor potential cation channel subfamily V member 1target Transient receptor potential cation channel subfamily V member 3target Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target
2-(l-menthoxy)ethanol	Not Annotated	No drug targets
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B15enzyme Sulfotransferase 1A1enzyme Sulfotransferase 1A3enzyme Arylamine N-acetyltransferase 2enzyme Prostaglandin E synthase 3target Transient receptor potential cation channel subfamily V member 1target Albumincarrier Fatty-acid amide hydrolase 1enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget
Arnica montana	Arnica montana is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.	No drug targets
Borneol	Not Annotated	Transient receptor potential cation channel subfamily V member 3target
Chondroitin sulfate	Chondroitin sulfate, used with glucosamine, is indicated to alleviate pain and inflammation from primary osteoarthritis. This supplement is reported to improve joint function and slow disease progression. Osteoarthritis is characterized...	Brain-derived neurotrophic factortarget Glial cell line-derived neurotrophic factortarget Vascular endothelial growth factor A, long formtarget C-C motif chemokine 2target Beta-glucuronidaseenzyme Beta-hexosaminidase subunit betaenzyme N-acetylgalactosamine-6-sulfataseenzyme Iduronate 2-sulfataseenzyme Alpha-L-iduronidaseenzyme Arylsulfatase Benzyme
Cinnamon oil	Not Annotated	No drug targets
Diclofenac	An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Transthyretincarrier Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier family 22 member 11transporter UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Sodium channel protein type 4 subunit alphatransporter Acid-sensing ion channel 1transporter Potassium voltage-gated channel subfamily KQT member 2transporter Potassium voltage-gated channel subfamily KQT member 3transporter Phospholipase A2, membrane associatedenzyme ATP-dependent translocase ABCB1transporter
Ethyl salicylate	A salicylate indicated in the treatment of sports related pain.	No drug targets
Etofenamate	An NSAID used to treat muscle and joint pain.	Thyroxine-binding globulincarrier
Eugenol	A phenol used for the temporary relief of toothaches.	Estrogen receptortarget Estrogen receptor betatarget Androgen receptortarget Transient receptor potential cation channel subfamily V member 3target Amine oxidase [flavin-containing] Btarget
Glycol salicylate	A salicylate used to treat mild to moderate muscle pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Heparin	An anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation.	Antithrombin-IIItarget Coagulation factor Xtarget P-selectintarget Heparanaseenzyme Fibroblast growth factor receptor 4target Fibroblast growth factor 4target Fibroblast growth factor 19target Fibroblast growth factor receptor 1target Fibroblast growth factor 1target Fibroblast growth factor receptor 2target Fibroblast growth factor 2target Platelet factor 4target Hepatocyte growth factortarget
Ketoprofen	An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target C-X-C chemokine receptor type 1target Albumincarrier ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme
Levomenthol	An organic compound used to treat mild to moderate muscle and joint pain.	Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 3target Kappa-type opioid receptortarget Voltage-dependent L-type calcium channeltarget Cytochrome P450 3A4enzyme
Menthyl salicylate	For the temporary relief of pain associated with rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and fibrositis .	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Methyl salicylate	A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons.	Transient receptor potential cation channel subfamily A member 1target
Myrtecaine	A local anesthetic used in topical products.	No drug targets
Nonivamide	Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , .	Transient receptor potential cation channel subfamily V member 1target
Orphenadrine	A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.	Glutamate receptor ionotropic, NMDA 1target Glutamate receptor ionotropic, NMDA 2Dtarget Glutamate receptor ionotropic, NMDA 3Btarget Glutamate receptor ionotropic, NMDA 3Atarget Histamine H1 receptortarget Cytochrome P450 2B6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Sodium-dependent noradrenaline transportertarget Sodium channel protein type 10 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Albumincarrier
Synthetic camphor	Not Annotated	No drug targets
Thymol	An essential oil found in various over-the-counter antibacterial and antifungal products.	No drug targets
Turpentine	A medication used to treat minor aches and pains of muscles and joints.	Mitogen-activated protein kinase 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00765700	Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury	Ketoprofen	treatment	3	completed
NCT02346786	Epidemiology of Incidents and Accidents in Sport. Influence of Moisture.	No drug interventions	prevention	3	unknown_status
NCT00351104	Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain	Ketoprofen	treatment	3	completed
NCT01223053	Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury	Ketoprofen	treatment	3	withdrawn
NCT01508728	Efficacy Study of a Sensory Feedback Knee Orthosis in Patients Suffering From Unoperated Severe Knee Sprain	No drug interventions	treatment	2	terminated
NCT00601471	Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability	No drug interventions	treatment	Not Available	completed
NCT00954785	Etoricoxib in Acute Ankle Ligament Sprains	Diclofenac Etoricoxib	treatment	4	withdrawn
NCT00671320	A Multi-Center, Randomized, Double-Blind, Parallel Group Study To Compare The Efficacy And Tolerability Of Valdecoxib And Diclofenac In Patients With A Sprained Ankle	Diclofenac Valdecoxib	treatment	4	completed
NCT02916940	Injection of Corticoids for the Treatment of Acute Sprains of the Proximal Interphalangeal Joints of the Fingers.	No drug interventions	treatment	2	completed
NCT02285868	ATI Evidence-based Guide Investigating Clinical Services	No drug interventions	Not Available	Not Available	unknown_status
NCT01097798	To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury.	No drug interventions	treatment	3	unknown_status
NCT03571737	Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department	Ibuprofen Lidocaine Menthol	treatment	3	completed
NCT00970658	Efficacy and Safety of Salonsip Compared to Sabiá Plaster	(+)-menthol Angelica archangelica root Carbomer Ginger Nicotinamide Safflower oil	treatment	3	unknown_status
NCT04908748	Efficacy and Safety of Esflurbiprofen Hydrogel Patch in the Treatment of Local Acute Pain	Esflurbiprofen	treatment	2	completed
NCT01373697	Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel	Ibuprofen Ketoprofen	treatment	3	unknown_status
NCT02115971	Jumping Exercises Approach in Individuals With Chronic Ankle Instability	No drug interventions	treatment	Not Available	terminated
NCT06528899	Physiotherapy in Emergency Department: a Service Analysis From a French Hospital	No drug interventions	Not Available	Not Available	completed
NCT05013567	Efficacy and Safety Study of Ibuprofen Gel Compared to Placebo in the Treatment of Acute Musculoskeletal Pain	Ibuprofen	treatment	3	unknown_status
NCT03912168	Question Prompt List for Orthopaedic Conditions	No drug interventions	health_services_research	Not Available	completed