Cutaneous Squamous Cell Carcinoma in Situ (CSCCis) (DBCOND0092857)

Identifiers

Synonyms

Bowen Disease / Bowens Disease / Cutaneous Squamous Cell Carcinoma in Situ / Squamous Cell Carcinoma in Situ / Bowen's Disease / Squamous cell carcinoma in situ (morphologic abnormality) / Squamous intraepithelial neoplasia, grade III (morphologic abnormality) / Intra-epidermal carcinoma / Intraepithelial squamous cell carcinoma (disorder) / Intraepidermal carcinoma / Bowen's disease (morphologic abnormality) / Squamous cell carcinoma in situ of skin (disorder) / Planocellular carcinoma / Squamous cell carcinoma (morphologic abnormality) / Squamous cell carcinoma (disorder) / Epidermoid carcinoma / Carcinoma, Squamous Cell / Squamous cell carcinoma / Carcinoma epidermoid / Carcinoma squamous

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aminolevulinic acid	A porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.	Delta-aminolevulinic acid dehydratasetarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Protoporphyrinogen oxidasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00166946	Effects of Arsenic on Keratinocytes in a Skin Equivalent Model	No drug interventions	educational_counseling_training	Not Available	unknown_status
NCT00384124	Topical Imiquimod for Bowen's Disease of the Head and Neck	Imiquimod	treatment	2 / 3	unknown_status
NCT00472459	PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer	No drug interventions	prevention	3	completed
NCT03333694	Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis)	No drug interventions	treatment	1	terminated
NCT04293679	Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC	Cotsiranib	treatment	1 / 2	completed
NCT04844983	A Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Patients With isSCC	Cotsiranib	treatment	2	completed
NCT04695015	Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm	No drug interventions	Not Available	Not Available	unknown_status
NCT01245972	Pilot Study of PDL to Treat BCC and SCCIS	No drug interventions	treatment	Not Available	completed
NCT05381597	5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer	Calcipotriol Fluorouracil	treatment	2 / 3	recruiting
NCT06014697	OCT and Invasion in Cutaneous Skin Lesions	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03012009	Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial	Epinephrine Lidocaine Methyl aminolevulinate	treatment	Not Available	completed
NCT01912976	Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease	No drug interventions	treatment	1	completed
NCT03167762	Photographing the Skin During Photodynamic Therapy	No drug interventions	supportive_care	Not Available	completed
NCT00535080	Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease	Methyl aminolevulinate	Not Available	Not Available	no_longer_available
NCT02085395	Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis	No drug interventions	treatment	2	completed
NCT03320447	Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease	Lidocaine Methyl aminolevulinate Prilocaine	treatment	1	completed
NCT02759900	Using a Cold Atmospheric Plasma Device to Treat Skin Disorders	No drug interventions	treatment	Not Available	recruiting
NCT00472706	Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease	No drug interventions	treatment	4	terminated
NCT05402046	Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms	No drug interventions	diagnostic	Not Available	unknown_status
NCT03909646	Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease	Fluorouracil Methyl aminolevulinate	treatment	4	recruiting