Systolic Left Ventricular Dysfunction (DBCOND0135402)

Identifiers

Synonyms

Left Ventricular Systolic Dysfunction / Left ventricular systolic dysfunction (disorder) / Impaired left ventricular function (finding) / Ventricular Dysfunction, Left / Left ventricular dysfunction

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Sacubitril	A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.	Neprilysintarget Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Valsartan	An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.	Type-1 angiotensin II receptortarget Cytochrome P450 2C9enzyme Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04662034	Performance and Safety of the Cardiac Microcurrent Therapy System	No drug interventions	treatment	Not Available	recruiting
NCT05189860	The C-MIC-II Follow-Up Study	No drug interventions	treatment	Not Available	recruiting
NCT05714085	Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)	Vericiguat	treatment	2 / 3	recruiting
NCT01747187	Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome	No drug interventions	Not Available	Not Available	unknown_status
NCT05647577	The Relationship Between Inflammatory ARTritis and CArdiac DIseAse	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06231797	AI-ECG Screening for Left Ventricular Systolic Dysfunction	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00752752	The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging	No drug interventions	Not Available	Not Available	completed
NCT03755570	How is COGNItive Function Affected by Cardiac Resynchronisation Therapy?	No drug interventions	Not Available	Not Available	suspended
NCT01842035	Heart Rate Response to Regadenoson and Sudden Cardiac Death	Regadenoson	diagnostic	Not Available	completed
NCT03352648	CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy: an International Registry (DERIVATE)	No drug interventions	Not Available	Not Available	unknown_status
NCT04249648	Hyperkalaemia and Its Impact on Therapy With RAASi	No drug interventions	Not Available	Not Available	recruiting
NCT04231331	Ertugliflozin for Functional Mitral Regurgitation	Ertugliflozin	treatment	3	completed
NCT03470155	Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function	No drug interventions	Not Available	Not Available	completed
NCT01969890	STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial	Filgrastim	treatment	3	terminated
NCT04399447	Multicenter Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD)	No drug interventions	Not Available	Not Available	unknown_status
NCT02851745	Effects of Linagliptin on Left Ventricular Myocardial DYsfunction in Patients With Type 2 DiAbetes Mellitus and Concentric Left Ventricular Geometry	Linagliptin	treatment	3	completed
NCT06270498	Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart Failure	No drug interventions	treatment	4	recruiting
NCT01162083	Identifying an Ideal Cardiopulmonary Exercise Test Parameter	No drug interventions	Not Available	Not Available	completed
NCT05764109	Adherence to Cied Implantation Guidelines and Cardiac Rehabilitation	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT01918215	Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction.	No drug interventions	prevention	Not Available	active_not_recruiting
NCT05861115	A Study to Evaluate Accuracy and Validity of the "Chang Gung" Ventricular Systolic Dysfunction Screening Software	No drug interventions	diagnostic	Not Available	completed
NCT01058837	SCD-HeFT 10 Year Follow-up	No drug interventions	Not Available	Not Available	unknown_status
NCT01500759	Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry	No drug interventions	Not Available	Not Available	completed
NCT02642770	3D & Speckle Tracking Together as a Marker for Early Outcome in Cardiac Surgery	No drug interventions	Not Available	Not Available	completed
NCT05630170	The SMART-LV Pilot Study	No drug interventions	device_feasibility	Not Available	completed
NCT01086124	Objective Systolic Function Recuperation Assessed by Echocardiography	No drug interventions	Not Available	Not Available	completed
NCT04221763	Mechanisms and Innovations in Cardiac Resynchronisation Therapy	No drug interventions	treatment	Not Available	completed
NCT04963686	Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients	No drug interventions	Not Available	Not Available	recruiting
NCT03993730	Cardiovascular Magnetic Resonance GUIDEd Insertion of Implantable Cardiac Defibrillator in Dilated CardioMyopathy	No drug interventions	prevention	Not Available	not_yet_recruiting
NCT05045274	The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction	Acetylsalicylic acid Angiotensin II Clopidogrel Dapagliflozin Ticagrelor	treatment	Not Available	unknown_status
NCT04166331	Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion	Dobutamine	treatment	3	recruiting
NCT06221891	Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography	No drug interventions	Not Available	Not Available	recruiting
NCT02642562	Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN	Ferric derisomaltose Iron Iron isomaltoside 1000 Peracetic acid	treatment	4	completed
NCT01786512	COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure	Omecamtiv Mecarbil	treatment	2	completed