Clomipramine is a tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA).
- Mechanism
- Curator reviewed
Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. α1-receptor blockage and β-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.
- Primary indication
- May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).Curator reviewed · 3 structured indications
- Formula / weight
- C19H23ClN2 · 314.852 g/mol (avg)
- First approval
- Canada, 1994 · United States, 1989
- Also known as
- 3-Chloroimipramine · Chlorimipramine · Monochlorimipramine
- Code names
- NSC-169865
- Brand names
Resolves to
GDLIGKIOYRNHDA-UHFFFAOYSA-NSMILESCN(C)CCCN1C2=CC=CC=C2CCC2=C1C=C(Cl)C=C2What you can answer from here — as of September 23, 2026
Which drugs share a target with Clomipramine, and which of those have an active Phase 3 trial?
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