Combination Contraceptives (with Estrogen and derivatives)

Combination Contraceptives (with Estrogen and derivatives)
Accession Number

Progestin contraceptives used in combination with estrogen derivatives, usually with Ethinyl Estradiol. Other estrogens include Estradiol derivatives such as estradiol cypionate, estradiol valerate, estradiol undecylate, and estradiol benzoate.

DrugDrug Description
Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
Hydroxyprogesterone caproateA synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.
NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
DienogestAn oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.
Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
GestodeneGestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol...
LynestrenolA progestin used for contraception and in the treatment of menstrual disorders.
NorelgestrominA progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
NorgestimateA progesterone used as a contraceptive and to treat acne vulgaris.
NorgestrelA progestin used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women.
ChlormadinoneA progestin indicated in combination with an estrogen for oral combined hormonal contraceptive therapy.
DesogestrelA synthetic progestin used in contraception, often in combination with ethinyl estradiol.
DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
Ethynodiol diacetateAn oral contraceptive used to prevent pregnancy.
LevonorgestrelA progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives.
Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
Nomegestrol acetateNomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
QuingestanolNot Annotated
EtonogestrelA long-acting synthetic derived progestin contraceptive used in various devices such as contraceptive rings and intradermal implants.
NorethynodrelA synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it...
NorgestrienoneNot Annotated
Drugs & Drug Targets
Cyproterone acetateAndrogen receptortarget
Cyproterone acetateProstate-specific antigentarget
Cyproterone acetateCytochrome P450 3A4enzyme
Cyproterone acetateCytochrome P450 19A1enzyme
Hydroxyprogesterone caproateProgesterone receptortarget
Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
NorethisteroneProgesterone receptortarget
NorethisteroneP-glycoprotein 1transporter
NorethisteroneCytochrome P450 2C19enzyme
NorethisteroneSerum albumincarrier
NorethisteroneSex hormone-binding globulincarrier
NorethisteroneAldo-keto reductase family 1 member C4enzyme
Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
NorethisteroneCytochrome P450 3A4enzyme
NorethisteroneCytochrome P450 1A2enzyme
NorethisteroneCytochrome P450 2A6enzyme
NorethisteroneGlucocorticoid receptortarget
NorethisteroneAndrogen receptortarget
DienogestCytochrome P450 3A4enzyme
DienogestProgesterone receptortarget
DienogestAndrogen receptortarget
Medroxyprogesterone acetateProgesterone receptortarget
Medroxyprogesterone acetateEstrogen receptor alphatarget
Medroxyprogesterone acetateCytochrome P450 3A4enzyme
Medroxyprogesterone acetateCytochrome P450 2C8enzyme
Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Medroxyprogesterone acetateCytochrome P450 2C9enzyme
Medroxyprogesterone acetateCytochrome P450 3A1enzyme
Medroxyprogesterone acetateSerum albumincarrier
Medroxyprogesterone acetateP-glycoprotein 1target
Medroxyprogesterone acetateGABA(A) Receptortarget
Medroxyprogesterone acetateP-glycoprotein 1transporter
GestodeneCytochrome P450 3A5enzyme
GestodeneCytochrome P450 3A7enzyme
GestodeneProgesterone receptortarget
GestodeneCytochrome P450 3A4enzyme
GestodeneCytochrome P450 2C19enzyme
LynestrenolCytochrome P450 3A4enzyme
LynestrenolCytochrome P450 2C9enzyme
LynestrenolCytochrome P450 2C19enzyme
NorelgestrominProgesterone receptortarget
NorelgestrominSerum albumintarget
NorelgestrominAndrogen receptortarget
NorelgestrominCytochrome P450 3A4enzyme
NorgestimateProgesterone receptortarget
NorgestimateEstrogen receptor alphatarget
NorgestimateCanalicular multispecific organic anion transporter 1transporter
NorgestimateCytochrome P450 3A4enzyme
NorgestimateAndrogen receptortarget
NorgestimateCytochrome P450 2B6enzyme
NorgestimateCytochrome P450 2C9enzyme
NorgestimateUDP-glucuronosyltransferase 1-1enzyme
NorgestimateSerum albumincarrier
NorgestimateSex hormone-binding globulincarrier
NorgestimateP-glycoprotein 1transporter
NorgestrelProgesterone receptortarget
Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
NorgestrelAndrogen receptortarget
NorgestrelCytochrome P450 3A4enzyme
NorgestrelCytochrome P450 19A1enzyme
ChlormadinoneCytochrome P450 3A4enzyme
DesogestrelProgesterone receptortarget
DesogestrelEstrogen receptor alphatarget
DesogestrelCytochrome P450 3A4enzyme
DesogestrelSerum albumincarrier
DesogestrelSex hormone-binding globulincarrier
DesogestrelCytochrome P450 2C9enzyme
DesogestrelUDP-glucuronosyltransferase 1-1enzyme
DrospirenoneProgesterone receptortarget
DrospirenoneMineralocorticoid receptortarget
DrospirenoneAndrogen receptortarget
DrospirenoneProstaglandin G/H synthase 2enzyme
DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DrospirenoneGlucocorticoid receptortarget
DrospirenoneCytochrome P450 3A4enzyme
Ethynodiol diacetateEstrogen receptor alphatarget
Ethynodiol diacetateProgesterone receptortarget
Ethynodiol diacetateCytochrome P450 3A4enzyme
LevonorgestrelProgesterone receptortarget
LevonorgestrelEstrogen receptor alphatarget
Levonorgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
LevonorgestrelCytochrome P450 3A4enzyme
LevonorgestrelAndrogen receptortarget
LevonorgestrelSex hormone-binding globulintarget
LevonorgestrelGlucocorticoid receptortarget
LevonorgestrelCytochrome P450 3A5enzyme
Megestrol acetateProgesterone receptortarget
Megestrol acetateGlucocorticoid receptortarget
Megestrol acetateP-glycoprotein 1transporter
Megestrol acetateCytochrome P450 3A4enzyme
Nomegestrol acetateCytochrome P450 3A4enzyme
QuingestanolCytochrome P450 3A4enzyme
EtonogestrelProgesterone receptortarget
EtonogestrelCytochrome P450 3A4enzyme
EtonogestrelSerum albumincarrier
EtonogestrelSex hormone-binding globulincarrier
NorethynodrelEstrogen receptor alphatarget
NorethynodrelAndrogen receptortarget
NorethynodrelSex hormone-binding globulintarget
NorethynodrelCytochrome P450 3A4enzyme