Ethylamines

Name
Ethylamines
Accession Number
DBCAT000433
Description

Derivatives of ethylamine (the structural formula CH3CH2NH2).

Drugs
DrugDrug Description
DofetilideA class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
SapropterinA cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU).
FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
MethoxamineAn alpha adrenergic agonist used to treat hypotension.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
CysteamineA cystine depleting agent used to treat the effects of cystinosis.
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
RitodrineAn adrenergic beta agonist used to treat premature labor.
PhenoxybenzamineAn alpha adrenergic agonist used to treat pheochromocytoma and episodes of hypertension and sweating.
DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
SalmeterolA long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD.
DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
DexfenfluramineFor the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
BromodiphenhydramineFor management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive.
LisdexamfetamineA central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
MephentermineA sympathomimetic agent used in the treatment of hypotension.
MMDAMMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present.
MidomafetamineClinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used...
2,5-DimethoxyamphetamineNot Available
2,5-Dimethoxy-4-ethylamphetamineNot Available
4-MethoxyamphetamineNot Available
FenethyllineNot Available
4-Bromo-2,5-dimethoxyamphetamineNot Available
TenamfetamineAn amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons...
4-Bromo-2,5-dimethoxyphenethylamineNot Available
FenproporexFenproporex is used as an appetite suppressant, and anti-obesity agent [2]; however, due to substance abuse potential, it is an illicit substance in many countries. In some countries, such as...
ChlorphentermineUsed as an appetite suppressant.
DextroamphetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
PhenethylamineNot Available
N-acetylhistamineNot Available
PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
HistamineAn ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
AlethineInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), lymphoma (unspecified), and multiple myeloma.
NylidrinA vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders.
IsoxsuprineA beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease.
HexoprenalineHexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent.
FendilineFendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
HydroxyamphetamineAn indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes.
Iofetamine I-123Not Annotated
RactopamineNot Annotated
EtafedrineA beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa.
OxilofrineAn amphetamine used to treat a cough associated with inflamed mucosa.
LanicemineLanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder.
RitobegronRitobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin...
MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
GallopamilGallopamil has been used in trials studying the treatment of Asthma.
TiaprideTiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.
MephedroneMephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders.
LevosalbutamolA beta-2 adrenergic receptor agonist used to treat COPD and asthma.
BamethanNot Annotated
PropanididAn intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)
OctopamineOctopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as...
SuloctidilNot Annotated
NorfenefrineNot Annotated
OxyfedrineNot Annotated
ClobenzorexNot Annotated
MethoxyphenamineNot Annotated
GepefrineNot Annotated
MefenorexNot Annotated
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties.
DexverapamilNot Annotated
EmopamilPrevents renal injury after warm & cold ischemia.
DiclofenacAn NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
MethylenedioxyethamphetamineNot Available
NAP-226-90Not Available
Hexamethylene diamineNot Available
CarmoterolNot Annotated
Drugs & Drug Targets
DrugTargetType
DofetilidePotassium channel subfamily K member 2target
DofetilidePotassium voltage-gated channel subfamily H member 2target
DofetilideATP-sensitive inward rectifier potassium channel 12target
DofetilideCytochrome P450 3A4enzyme
DofetilideSolute carrier family 22 member 2transporter
VenlafaxineSodium-dependent serotonin transportertarget
VenlafaxineSodium-dependent noradrenaline transportertarget
VenlafaxineCytochrome P450 2D6enzyme
VenlafaxineCytochrome P450 3A4enzyme
VenlafaxineSodium-dependent dopamine transportertarget
VenlafaxineP-glycoprotein 1transporter
VenlafaxineATP-binding cassette sub-family G member 2transporter
SapropterinPhenylalanine-4-hydroxylasetarget
SapropterinNitric oxide synthase, endothelialtarget
SapropterinTyrosine 3-monooxygenasetarget
SapropterinTryptophan 5-hydroxylase 1target
SapropterinProstaglandin G/H synthase 2enzyme
Fenfluramine5-hydroxytryptamine receptor 2Ctarget
Fenfluramine5-hydroxytryptamine receptor 2Btarget
FenfluramineCytochrome P450 2D6enzyme
FenfluramineSodium-dependent serotonin transportertarget
Fenfluramine5-hydroxytryptamine receptor 2Atarget
FenfluramineSodium-dependent serotonin transportertransporter
Fenfluramine5-hydroxytryptamine receptor 1Dtarget
FenfluramineSigma non-opioid intracellular receptor 1target
Fenfluramine5-hydroxytryptamine receptor 1Atarget
FenfluramineCytochrome P450 1A2enzyme
FenfluramineCytochrome P450 2B6enzyme
FenfluramineCytochrome P450 2C9enzyme
FenfluramineCytochrome P450 2C19enzyme
FenfluramineCytochrome P450 3A4enzyme
FenfluramineCytochrome P450 3A5enzyme
MethoxamineAlpha-1A adrenergic receptortarget
MethoxamineAlpha-1B adrenergic receptortarget
MethoxamineAlpha-1D adrenergic receptortarget
DobutamineBeta-1 adrenergic receptortarget
DobutamineCatechol O-methyltransferaseenzyme
DobutamineBeta-2 adrenergic receptortarget
DobutamineAlpha-1 adrenergic receptorstarget
DobutamineEstrogen receptor alphatarget
CysteamineNeuropeptide Y receptor type 2target
CysteamineCystinetarget
CysteamineMyeloperoxidaseenzyme
CysteamineSerum albumincarrier
PseudoephedrineAlpha-1A adrenergic receptortarget
PseudoephedrineAlpha-2A adrenergic receptortarget
PseudoephedrineBeta-2 adrenergic receptortarget
PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
PseudoephedrineBeta-1 adrenergic receptortarget
PseudoephedrineSodium-dependent dopamine transportertarget
PseudoephedrineSodium-dependent noradrenaline transportertarget
PseudoephedrineSodium-dependent serotonin transportertarget
PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
PseudoephedrineTumor necrosis factortarget
PseudoephedrineNuclear factor NF-kappa-B p105 subunittarget
Pseudoephedrineactivator protein 1target
PseudoephedrineInterleukin-2target
PseudoephedrineSerum albumincarrier
PseudoephedrineSodium-dependent noradrenaline transportertransporter
PseudoephedrineSodium-dependent dopamine transportertransporter
PseudoephedrineSodium-dependent serotonin transportertransporter
BenzphetamineAlpha-2A adrenergic receptortarget
BenzphetamineAlpha-1A adrenergic receptortarget
BenzphetamineCytochrome P450 3A4enzyme
BenzphetamineCytochrome P450 2B6enzyme
BenzphetamineNADPH--cytochrome P450 reductaseenzyme
BenzphetamineSynaptic vesicular amine transportertarget
BenzphetamineSodium-dependent dopamine transportertarget
RitodrineBeta-2 adrenergic receptortarget
Ritodrine6-phosphogluconate dehydrogenase, decarboxylatingenzyme
PhenoxybenzamineAlpha-1A adrenergic receptortarget
PhenoxybenzamineCalmodulintarget
PhenoxybenzamineSolute carrier family 22 member 2transporter
PhenoxybenzamineSolute carrier family 22 member 1transporter
PhenoxybenzamineSolute carrier family 22 member 3transporter
PhenoxybenzamineAlpha-2A adrenergic receptortarget
PhenoxybenzamineAlpha-2C adrenergic receptortarget
PhenoxybenzamineAlpha-2B adrenergic receptortarget
PhenoxybenzamineBeta-2 adrenergic receptortarget
PhenoxybenzamineAlpha-1B adrenergic receptortarget
PhenoxybenzamineAlpha-1D adrenergic receptortarget
DiethylpropionSodium-dependent noradrenaline transportertarget
DiethylpropionSodium-dependent dopamine transportertarget
SalmeterolBeta-2 adrenergic receptortarget
SalmeterolCytochrome P450 3A4enzyme
SalmeterolCytochrome P450 2C8enzyme
SalmeterolCytochrome P450 3A5enzyme
SalmeterolCytochrome P450 3A7enzyme
SalmeterolBeta-1 adrenergic receptortarget
SalmeterolBeta-3 adrenergic receptortarget
SalmeterolSerum albumincarrier
Salmeterolalpha1-acid glycoproteincarrier
SalmeterolSolute carrier family 22 member 1transporter
SalmeterolSolute carrier family 22 member 2transporter
SalmeterolSolute carrier family 22 member 3transporter
DimenhydrinateHistamine H1 receptortarget
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
SelegilineCytochrome P450 2E1enzyme
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
OrphenadrineGlutamate receptor ionotropic, NMDA 1target
OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
OrphenadrineHistamine H1 receptortarget
OrphenadrineCytochrome P450 2B6enzyme
OrphenadrineCytochrome P450 2E1enzyme
OrphenadrineCytochrome P450 3A4enzyme
OrphenadrineSodium-dependent noradrenaline transportertarget
OrphenadrineSodium channel protein type 10 subunit alphatarget
OrphenadrineCytochrome P450 1A2enzyme
OrphenadrineCytochrome P450 2D6enzyme
DexfenfluramineSodium-dependent serotonin transportertarget
Dexfenfluramine5-hydroxytryptamine receptor 2Ctarget
DexfenfluramineCytochrome P450 2D6enzyme
DexfenfluramineCytochrome P450 1A2enzyme
DexfenfluramineCytochrome P450 2E1enzyme
BromodiphenhydramineHistamine H1 receptortarget
BromodiphenhydramineSolute carrier family 22 member 6transporter
LisdexamfetamineCytochrome P450 2D6enzyme
LisdexamfetamineSolute carrier family 15 member 1transporter
LisdexamfetamineTrace amine-associated receptor 1target
EphedrineAlpha-1A adrenergic receptortarget
EphedrineSodium-dependent noradrenaline transportertarget
EphedrineCholinesteraseenzyme
EphedrineSerum albumincarrier
EphedrineBeta-1 adrenergic receptortarget
EphedrineBeta-2 adrenergic receptortarget
EphedrineSynaptic vesicular amine transportertransporter
EphedrineAcetylcholinesteraseenzyme
MephentermineAlpha adrenergic receptortarget
MephentermineBeta adrenergic receptortarget
MMDA5-hydroxytryptamine receptor 2Atarget
MMDASodium-dependent serotonin transportertarget
MMDASodium-dependent dopamine transportertarget
MMDAChromaffin granule amine transportertarget
MMDASynaptic vesicular amine transportertarget
MMDAAmine oxidase [flavin-containing] Atarget
MMDAAmine oxidase [flavin-containing] Btarget
MMDASodium-dependent noradrenaline transportertarget
MidomafetamineSodium-dependent serotonin transportertarget
MidomafetamineSynaptic vesicular amine transportertarget
MidomafetamineSodium-dependent dopamine transportertarget
Midomafetamine5-hydroxytryptamine receptor 2Atarget
Midomafetamine5-hydroxytryptamine receptor 2Btarget
Midomafetamine5-hydroxytryptamine receptor 2Ctarget
MidomafetamineSodium-dependent noradrenaline transportertarget
MidomafetamineSodium-dependent noradrenaline transportertransporter
MidomafetamineSodium-dependent dopamine transportertransporter
MidomafetamineSodium-dependent serotonin transportertransporter
MidomafetamineCytochrome P450 2D6enzyme
4-MethoxyamphetamineAlpha-1A adrenergic receptortarget
4-MethoxyamphetamineAlpha-2A adrenergic receptortarget
4-MethoxyamphetamineCytochrome P450 2D6enzyme
4-MethoxyamphetamineSodium-dependent dopamine transportertarget
4-MethoxyamphetamineSodium-dependent serotonin transportertarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Atarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Btarget
4-MethoxyamphetamineSynaptic vesicular amine transportertarget
FenethyllineCytochrome P450 1A2enzyme
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Ctarget
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Atarget
DextroamphetamineAlpha-1B adrenergic receptortarget
DextroamphetamineSodium-dependent dopamine transportertarget
DextroamphetamineSodium-dependent noradrenaline transportertarget
DextroamphetamineSynaptic vesicular amine transportertarget
DextroamphetamineTrace amine-associated receptor 1target
DextroamphetamineCytochrome P450 2D6enzyme
DextroamphetaminePrimary amine oxidaseenzyme
DextroamphetamineSodium-dependent dopamine transportertransporter
DextroamphetamineAlpha adrenergic receptortarget
MetamfetamineCytochrome P450 2D6enzyme
MetamfetamineSolute carrier family 22 member 3transporter
MetamfetamineSolute carrier family 22 member 5transporter
MetamfetamineSodium-dependent dopamine transportertarget
MetamfetamineSynaptic vesicular amine transportertarget
MetamfetamineTrace amine-associated receptor 1target
MetamfetamineSodium-dependent serotonin transportertarget
MetamfetamineSodium-dependent noradrenaline transportertarget
MetamfetamineChromaffin granule amine transportertarget
MetamfetamineAmine oxidase [flavin-containing] Atarget
MetamfetamineAmine oxidase [flavin-containing] Btarget
MetamfetamineAlpha-2A adrenergic receptortarget
MetamfetamineAlpha-2B adrenergic receptortarget
MetamfetamineAlpha-2C adrenergic receptortarget
PhenethylamineTrypsin-1target
PhenethylaminePrimary amine oxidasetarget
PhenethylamineTrypsin-2target
N-acetylhistamineGlutaminyl-peptide cyclotransferasetarget
PrenylamineCalmodulintarget
PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
PrenylamineCytochrome P450 3A4enzyme
HistamineHistamine H1 receptortarget
HistamineHistamine H2 receptortarget
HistamineHistamine H3 receptortarget
HistamineHistamine N-methyltransferaseenzyme
HistamineSolute carrier family 22 member 2transporter
HistamineSolute carrier family 22 member 1transporter
HistamineSolute carrier family 22 member 3transporter
HistamineSolute carrier family 22 member 5transporter
HistamineHistamine H4 receptortarget
HistamineSynaptic vesicular amine transportertarget
NylidrinCatechol O-methyltransferaseenzyme
NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
NylidrinInterferon alpha/beta receptor 2target
NylidrinCytochrome P450 3A4enzyme
FendilineCytochrome P450 3A4enzyme
RactopamineEstrogen receptor alphatarget
EtafedrineBeta-2 adrenergic receptortarget
GallopamilCytochrome P450 3A4enzyme
GallopamilP-glycoprotein 1transporter
TiaprideDopamine D2 receptortarget
TiaprideDopamine D3 receptortarget
TiaprideSerotonin Receptorstarget
TiaprideAlpha-1 adrenergic receptorstarget
TiaprideAlpha-2 adrenergic receptorstarget
LevosalbutamolBeta-2 adrenergic receptortarget
LevosalbutamolCytochrome P450 3A4enzyme
LevosalbutamolCytochrome P450 2D6enzyme
LevosalbutamolSolute carrier organic anion transporter family member 1B1transporter
LevosalbutamolSolute carrier organic anion transporter family member 1B3transporter
2,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Atarget
2,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Ctarget
DexverapamilP-glycoprotein 1target
DexverapamilCytochrome P450 3A4enzyme
DexverapamilP-glycoprotein 1transporter
EmopamilP-glycoprotein 1target
EmopamilCytochrome P450 3A4enzyme
EmopamilP-glycoprotein 1transporter
DiclofenacProstaglandin G/H synthase 1target
DiclofenacProstaglandin G/H synthase 2target
DiclofenacTransthyretincarrier
DiclofenacCytochrome P450 2C9enzyme
DiclofenacCytochrome P450 2C19enzyme
DiclofenacCytochrome P450 1A2enzyme
DiclofenacCytochrome P450 2C8enzyme
DiclofenacSerum albumincarrier
DiclofenacMultidrug resistance-associated protein 4transporter
DiclofenacMultidrug resistance-associated protein 1transporter
DiclofenacSolute carrier family 22 member 6transporter
DiclofenacSolute carrier family 22 member 8transporter
DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DiclofenacSolute carrier family 22 member 11transporter
DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DiclofenacCytochrome P450 3A4enzyme
DiclofenacCytochrome P450 2B6enzyme
DiclofenacCytochrome P450 2C18enzyme
DiclofenacCytochrome P450 2E1enzyme
DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DiclofenacBile salt export pumptransporter
DiclofenacUDP-glucuronosyltransferase 1-3enzyme
DiclofenacUDP-glucuronosyltransferase 1-9enzyme
DiclofenacUDP-glucuronosyltransferase 2B4enzyme
DiclofenacArachidonate 5-lipoxygenaseenzyme
DiclofenacSodium channel protein type 4 subunit alphatransporter
DiclofenacAcid-sensing ion channel 1transporter
DiclofenacPotassium voltage-gated channel subfamily KQT member 2transporter
DiclofenacPotassium voltage-gated channel subfamily KQT member 3transporter
DiclofenacPhospholipase A2, membrane associatedenzyme
DiclofenacP-glycoprotein 1transporter
NAP-226-90Acetylcholinesterasetarget
Hexamethylene diamineAgmatinase, putativetarget