Phosphodiesterase 4 Inhibitors

All categories
Name
Phosphodiesterase 4 Inhibitors
Accession Number
DBCAT001410
Description

Compounds that specifically inhibit PHOSPHODIESTERASE 4.

Drugs
DrugDrug Description
RoflumilastA selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat skin conditions such as plaque psoriasis and atopic dermatitis.
PiclamilastPiclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as...
RolipramA phosphodiesterase inhibitor with antidepressant properties.
GSK-256066Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others.
E-6005E6005 has been used in trials studying the treatment of Atopic Dermatitis.
MK-0873MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis.
CilomilastInvestigated for use/treatment in chronic obstructive pulmonary disease (COPD).
CrisaboroleA non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
ApremilastA non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis.
DrotaverineA phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms.
DovramilastDovramilast is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus...
ZatolmilastBPN-14770 is under investigation in clinical trial NCT02840279 (A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects).
EnsifentrineA phosphodiesterase inhibitor used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults.
Drugs & Drug Targets
DrugTargetType
RoflumilastCytochrome P450 3A4enzyme
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target
RoflumilastCytochrome P450 1A2enzyme
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target
RolipramcGMP-specific 3',5'-cyclic phosphodiesterasetarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
GSK-256066cAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
MK-0873cAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
MK-0873cAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
MK-0873cAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CrisaboroleCytochrome P450 2B6enzyme
CrisaboroleCytochrome P450 2C8enzyme
CrisaboroleCytochrome P450 2C9enzyme
ApremilastPhosphodiesterase isozyme 4target
ApremilastCytochrome P450 3A4enzyme
ApremilastCytochrome P450 2A6enzyme
ApremilastCytochrome P450 1A2enzyme
ApremilastP-glycoprotein 1transporter
ApremilastCyclin-dependent kinase 6target
ApremilastCyclin-dependent kinase 4target
DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DrotaverineVoltage-dependent L-type calcium channeltarget
ZatolmilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
EnsifentrineCytochrome P450 2C9enzyme
EnsifentrineCytochrome P450 2D6enzyme
EnsifentrinePhosphodiesterase 3target
EnsifentrinePhosphodiesterase 4target
EnsifentrineATP-binding cassette sub-family G member 2transporter