Anti-Allergic Agents

Anti-Allergic Agents
Accession Number

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

DrugDrug Description
NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
OlopatadineA histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis.
KetotifenA histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis.
LodoxamideAn ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
OmalizumabA monoclonal anti-immunoglobulin E antibody used in the treatment of severe asthma and chronic idiopathic urticaria.
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
TriprolidineA sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
CyproheptadineA combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
LoratadineA second generation antihistamine used to manage the symptoms of allergic rhinitis.
Fluticasone propionateA glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
AstemizoleA second generation antihistamine used to treat allergy symptoms.
MeclizineA histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
MometasoneA corticosteroid with no indications.
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
BrompheniramineA histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.
Loteprednol etabonateA corticosteroid used to treat allergic conjunctivitis as well as inflammation and pain after ocular surgery.
FexofenadineA selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
AmlexanoxUsed as a paste in the mouth to treat aphthous ulcers (canker sores).
FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
MequitazineFor the treatment of Hay fever, urticaria (hives) and allergic rhinitis
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
EmedastineA selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.
ChlorpheniramineA histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
CiclesonideA glucocorticoid used in the symptomatic relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents.
PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
AntazolineAn antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis.
DimetindeneA 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
TixocortolA corticosteroid used for the symptomatic treatment of rhinitis, pharyngitis, and ulcerative colitis.
Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
OxatomideAn antihistamine indicated in the treatment and prevention of allergic symptoms.
FluticasoneA corticosteroid indicated in the treatment of corticosteroid responsive dermatoses, asthma, and COPD.
Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
LevocabastineA selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
BepotastineAn ophthalmic H1 antagonist used to treat itchiness associated with allergic conjunctivitis.
Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
LoteprednolA corticosteroid indicated in the treatment of pain and inflammation after cataract surgery.
MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Drugs & Drug Targets
NedocromilCysteinyl leukotriene receptor 1target
NedocromilCysteinyl leukotriene receptor 2target
NedocromilProstaglandin D2 receptortarget
NedocromilfMet-Leu-Phe receptortarget
NedocromilHeat shock protein HSP 90-alphatarget
OlopatadineHistamine H1 receptortarget
OlopatadineProtein S100-A1target
OlopatadineProtein S100-A12target
OlopatadineProtein S100-Btarget
OlopatadineProtein S100-A13target
OlopatadineProtein S100-A2target
OlopatadineCytochrome P450 3A4enzyme
OlopatadineSerum albumincarrier
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
OlopatadineP-glycoprotein 1transporter
OlopatadineHistamine H2 receptortarget
OlopatadineHistamine H3 receptortarget
KetotifenHistamine H1 receptortarget
Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
KetotifenUDP-glucuronosyltransferase 1-3enzyme
KetotifenUDP-glucuronosyltransferase 1-4enzyme
KetotifenUDP-glucuronosyltransferase 2B10enzyme
OmalizumabHigh affinity immunoglobulin epsilon receptor subunit alphatarget
OmalizumabHigh affinity immunoglobulin epsilon receptor subunit betatarget
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
FluorometholoneCorticosteroid-binding globulincarrier
FluorometholoneCytochrome P450 3A4enzyme
FluorometholoneGlucocorticoid receptortarget
FluorometholoneCytochrome P450 3A5enzyme
CetirizineHistamine H1 receptortarget
CetirizineP-glycoprotein 1transporter
TriprolidineHistamine H1 receptortarget
TriprolidineSerum albumincarrier
Cyproheptadine5-hydroxytryptamine receptor 2Atarget
CyproheptadineHistamine H1 receptortarget
CyproheptadineMuscarinic acetylcholine receptor M1target
CyproheptadineMuscarinic acetylcholine receptor M2target
CyproheptadineMuscarinic acetylcholine receptor M3target
Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
Cyproheptadine5-hydroxytryptamine receptor 7target
CyproheptadineUDP-glucuronosyltransferase 2B10enzyme
CyproheptadineUDP-glucuronosyltransferase 1-4enzyme
Cyproheptadine5-hydroxytryptamine receptor 2Btarget
CyproheptadineHistamine H2 receptortarget
CyproheptadineSolute carrier family 22 member 1transporter
CyproheptadineSerum albumincarrier
LoratadineHistamine H1 receptortarget
LoratadineCytochrome P450 3A4enzyme
LoratadineCytochrome P450 2C19enzyme
LoratadineCytochrome P450 2D6enzyme
LoratadineCytochrome P450 2C8enzyme
LoratadineP-glycoprotein 1transporter
LoratadinePotassium voltage-gated channel subfamily H member 2target
LoratadineBile salt export pumptransporter
LoratadineCytochrome P450 1A1enzyme
LoratadineCytochrome P450 1A2enzyme
LoratadineCytochrome P450 2B6enzyme
LoratadineCytochrome P450 2C9enzyme
LoratadineCytochrome P450 3A5enzyme
LoratadineUDP-glucuronosyltransferase 2B10enzyme
LoratadineUDP-glucuronosyltransferase 1-1enzyme
LoratadineUDP-glucuronosyltransferase 1-3enzyme
LoratadineUDP-glucuronosyltransferase 2B15enzyme
Fluticasone propionateCorticosteroid-binding globulincarrier
Fluticasone propionateCytosolic phospholipase A2target
Fluticasone propionateGlucocorticoid receptortarget
Fluticasone propionateCytochrome P450 3A4enzyme
Fluticasone propionateProgesterone receptortarget
Fluticasone propionateMineralocorticoid receptortarget
Fluticasone propionateCytochrome P450 3A5enzyme
Fluticasone propionateCytochrome P450 3A7enzyme
Fluticasone propionateCytochrome P450 2C8enzyme
Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
Fluticasone propionateP-glycoprotein 1transporter
Fluticasone propionateSolute carrier organic anion transporter family member 1B1transporter
AstemizoleHistamine H1 receptortarget
AstemizolePotassium voltage-gated channel subfamily H member 2target
AstemizoleCytochrome P450 3A4enzyme
AstemizoleCytochrome P450 3A5enzyme
AstemizoleCytochrome P450 3A7enzyme
AstemizoleP-glycoprotein 1transporter
AstemizoleCytochrome P450 2D6enzyme
AstemizoleCytochrome P450 2J2enzyme
AstemizolePotassium voltage-gated channel subfamily H member 1target
AstemizoleMicrotubule-associated protein tautarget
AstemizoleBile salt export pumptransporter
MeclizineHistamine H1 receptortarget
MeclizineNuclear receptor subfamily 1 group I member 3target
MeclizineCytochrome P450 2D6enzyme
MeclizineSerum albumincarrier
MometasoneGlucocorticoid receptortarget
MometasoneCytochrome P450 2C8enzyme
MometasoneProgesterone receptortarget
MometasoneCytochrome P450 3A4enzyme
MometasoneCytochrome P450 3A5enzyme
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
TripelennamineSerum albumincarrier
BrompheniramineHistamine H1 receptortarget
BrompheniramineMuscarinic acetylcholine receptor M1target
BrompheniramineMuscarinic acetylcholine receptor M2target
BrompheniramineMuscarinic acetylcholine receptor M3target
BrompheniramineMuscarinic acetylcholine receptor M4target
BrompheniramineMuscarinic acetylcholine receptor M5target
Loteprednol etabonateGlucocorticoid receptortarget
Loteprednol etabonateCytochrome P450 3A4enzyme
Loteprednol etabonateSerum paraoxonase/arylesterase 1enzyme
FexofenadineHistamine H1 receptortarget
FexofenadineP-glycoprotein 1transporter
FexofenadineSolute carrier organic anion transporter family member 2B1transporter
FexofenadineSolute carrier organic anion transporter family member 1A2transporter
FexofenadineSolute carrier organic anion transporter family member 1B1transporter
FexofenadineSolute carrier organic anion transporter family member 1B3transporter
FexofenadineSolute carrier family 22 member 8transporter
FexofenadineCanalicular multispecific organic anion transporter 1transporter
FexofenadineCanalicular multispecific organic anion transporter 2transporter
FexofenadineSerum albumincarrier
Fexofenadinealpha1-acid glycoproteincarrier
AzelastineHistamine H1 receptortarget
AzelastineCytochrome P450 1A2enzyme
AzelastineCytochrome P450 2D6enzyme
AzelastineCytochrome P450 3A4enzyme
AzelastineCytochrome P450 2C19enzyme
AzelastineCytochrome P450 1A1enzyme
AzelastineCytochrome P450 3A5enzyme
AzelastineCytochrome P450 2C9enzyme
AzelastineCytochrome P450 2C8enzyme
AzelastineP-glycoprotein 1transporter
AzelastineCytochrome P450 2A6enzyme
AzelastineCytochrome P450 2E1enzyme
AzelastineHistamine H2 receptortarget
AzelastinePhospholipase A2target
AzelastineLeukotriene C4 synthasetarget
AzelastineCytochrome P450 2B6enzyme
AmlexanoxProtein S100-A12target
AmlexanoxProtein S100-A13target
AmlexanoxFibroblast growth factor 1target
FluocinonideCorticosteroid-binding globulincarrier
FluocinonideGlucocorticoid receptortarget
FluocinonideSmoothened homologtarget
FluocinonideCytochrome P450 3A4enzyme
FluocinonideCytochrome P450 3A5enzyme
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
MequitazineHistamine H1 receptortarget
MequitazineCytochrome P450 2D6enzyme
MequitazineCytochrome P450 3A4enzyme
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
EmedastineHistamine H1 receptortarget
ChlorpheniramineHistamine H1 receptortarget
ChlorpheniramineCytochrome P450 3A4enzyme
ChlorpheniramineCytochrome P450 2D6enzyme
ChlorpheniramineSodium-dependent serotonin transportertarget
ChlorpheniramineSodium-dependent noradrenaline transportertarget
ChlorpheniramineSodium-dependent dopamine transportertarget
ChlorpheniramineCytochrome P450 3A5enzyme
ChlorpheniramineCytochrome P450 3A7enzyme
ChlorpheniramineSolute carrier family 22 member 2transporter
ChlorpheniramineSolute carrier family 22 member 1transporter
CiclesonideCorticosteroid-binding globulincarrier
CiclesonideCytochrome P450 3A4enzyme
CiclesonideCytochrome P450 2D6enzyme
CiclesonideGlucocorticoid receptortarget
CiclesonideLiver carboxylesterase 1enzyme
PheniramineHistamine H1 receptortarget
PheniramineNuclear receptor subfamily 1 group I member 3target
PheniramineHistamine H4 receptortarget
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
AntazolineHistamine H1 receptortarget
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
TixocortolGlucocorticoid receptortarget
TixocortolHistone deacetylase 2target
Dexamethasone isonicotinateCytochrome P450 3A4enzyme
Dexamethasone isonicotinateCytochrome P450 3A5enzyme
FluticasoneCytochrome P450 3A4enzyme
FluticasoneCytochrome P450 2C8enzyme
FluticasoneP-glycoprotein 1carrier
FluticasoneSolute carrier organic anion transporter family member 1B1carrier
FluticasoneP-glycoprotein 1transporter
FluticasoneSolute carrier organic anion transporter family member 1B1transporter
FluticasoneGlucocorticoid receptortarget
FluticasoneCorticosteroid-binding globulincarrier
FluticasoneCytochrome P450 3A5enzyme
FluticasoneCytochrome P450 3A7enzyme
FluticasoneProgesterone receptortarget
FluticasoneCytosolic phospholipase A2target
FluticasoneMineralocorticoid receptortarget
Cromoglicic acidProtein S100-Ptarget
LevocabastineNeurotensin receptor type 2target
LevocabastineHistamine H1 receptortarget
BepotastineHistamine H1 receptortarget
Mometasone furoateGlucocorticoid receptortarget
Mometasone furoateCytochrome P450 2C8enzyme
Mometasone furoateProgesterone receptortarget
Mometasone furoateCytochrome P450 3A4enzyme
Mometasone furoateCytochrome P450 3A5enzyme
TranilastHematopoietic prostaglandin D synthasetarget
TranilastCytochrome P450 3A4enzyme
TranilastCytochrome P450 2C9enzyme