Serotonin Receptor Antagonists
- Serotonin Receptor Antagonists
- Accession Number
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
- ATC Classification
Drug Drug Description Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Cyproheptadine A serotonin and histamine antagonist used in the treatment of allergy symptoms and in combination with epinephrine in the treatment of anaphylaxis. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). APD791 For the treatment and prophylaxis of arterial thrombosis. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Mianserin For the treatment of depression. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Dotarizine Investigated for use/treatment in migraine and cluster headaches. Deramciclane Investigated for use/treatment in anxiety disorders. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Vortioxetine An atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Ramosetron For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males. Iferanserin Iferanserin has been investigated for the treatment of Hemorrhoids. Tropisetron For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. Eplivanserin Eplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others. Cerlapirdine Cerlapirdine has been investigated for the treatment of Alzheimer Disease. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Iprazochrome Not Annotated Naftidrofuryl Not Annotated Cilansetron For the treatment of symptoms associated with irritable bowel syndrome. Wortmannin Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Chlorprothixene For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. Lisuride For the management of Parkinson's Disease Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. PRX-08066 Investigated for use/treatment in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Nefazodone An antidepressant used in the treatment of depression. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Promazine A phenothiazine used to manage schizophrenia. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Epinastine An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. Sertindole Used in the treatment of schizophrenia. Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Loxapine A antipsychotic used for the treatment of schizophrenia. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Desipramine A tricyclic antidepressant used in the treatment of depression. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Cinitapride It is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... Blonanserin Used for the treatment of schizophrenia . Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Trimipramine A tricyclic antidepressant used to treat depression. Captodiame Captodiame is indicated for the treatment of anxiety. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Alprenolol For the treatment of hypertension, angina, and arrhythmia Alverine Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to... Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Dosulepin Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Minaprine For the treatment of depression Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Molindone An antipsychotic used to treat schizophrenia. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Amisulpride Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Thiothixene An antipsychotic indicated for the management of schizophrenia. Lorpiprazole In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic. An antipsychotic is a medication used to treat a state... Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. SUVN-502 Investigated for use/treatment in neurologic disorders. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Metergoline Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration...
- Drugs & Drug Targets