Anti-Anxiety Agents

Anti-Anxiety Agents
Accession Number

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.

ATC Classification
DrugDrug Description
LorazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
MeprobamateAn anxiolytic drug used for the short-term management of anxiety symptoms.
AlprazolamA triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
ChlordiazepoxideA benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period.
HalazepamUsed to relieve anxiety, nervousness, and tension associated with anxiety disorders.
DiazepamA long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures.
OxazepamAn intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia.
Ethyl loflazepateNot Available
BromazepamA short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety.
FludiazepamUsed for the short-term treatment of anxiety disorders.
KetazolamA long-acting benzodiazepine used to manage anxiety and insomnia.
PrazepamA benzodiazepine used to manage more severe forms of anxiety disorders.
EtifoxineA benzoxazine class drug primarily used as an anxiolytic, but that also possesses neuroprotective, neuroplastic, and anti-inflammatory properties; these effects are thought to arise due to modulation of GABAergic neurotransmission and neurosteroid synthesis.
MedazepamA long-acting benzodiazepine used for its sedative and anxiolytic properties.
NordazepamA benzodiazepine indicated in the treatment of insomnia.
FluvoxamineA selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
TemazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia.
Clorazepic acidA benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
MidazolamA short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
FlurazepamA long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia.
TranylcypromineA monoamine oxidase inhibitor used to treat major depressive disorder.
TriazolamA benzodiazepine used for short term treatment of insomnia.
OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
ChlormezanoneUsed in the management of anxiety and in the treatment of muscle spasm.
EstazolamA benzodiazepine used for the short-term management of insomnia.
FlunitrazepamA benzodiazepine used to manage anxiety disorders and insomnia.
OxprenololA non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety.
NitrazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures.
7-NitroindazoleNot Available
DeramciclaneInvestigated for use/treatment in anxiety disorders.
AdipiplonInvestigated for use/treatment in insomnia and sleep disorders.
CyamemazineCyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an...
VortioxetineA serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD).
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
ZolazepamZolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It...
ImagabalinImagabalin has been investigated in Generalized Anxiety Disorder.
GepironeA serotonin receptor agonist used to treat major depressive disorder in adults
RitanserinRitanserin has been used in trials studying the treatment of Cocaine-Related Disorders.
TandospironeTandospirone has been used in trials studying the treatment of Schizophrenia.
MebicarNot Annotated
LoprazolamLoprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent...
MRK-409MRK-409 is a GABA-A receptor agonist .
ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
AdinazolamFor the treatment of anxiety and status epilepticus.
HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
CamazepamCamazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression.
CloxazolamUsed primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to...
ClotiazepamA thienodiazepine used to manage anxiety disorders and insomnia.
MebutamateMebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a...
TofisopamFor the treatment of anxiety and alcohol withdrawal.
CaptodiameCaptodiame is indicated for the treatment of anxiety.
BenzoctamineBenzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be...
EtizolamA thienodiazepine derivative used to treat anxiety and insomnia.
PinazepamA benzodiazepine indicated in the treatment of anxiety and severe insomnia.
GedocarnilNot Annotated
EmylcamateNot Annotated
FabomotizoleNot Annotated
MephenoxaloneA muscle relaxant indicated in the treatment of painful muscle spasms and cramps.
MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
EsmirtazapineInvestigated for use/treatment in insomnia and sleep disorders.
ButriptylineButriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.
BentazepamNot Annotated
MexazolamA benzodiazepine indicated to treat anxiety with or without psychoneurotic conditions.
ZK-93423ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.
Drugs & Drug Targets
LorazepamUDP-glucuronosyltransferase 2B15enzyme
LorazepamGABA(A) Receptortarget
LorazepamCytochrome P450 3A4enzyme
LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MeprobamateGamma-aminobutyric acid receptor subunit alpha-1target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-2target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-3target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-4target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-5target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-6target
MeprobamateGABA(A) Receptortarget
AlprazolamCytochrome P450 3A4enzyme
AlprazolamCytochrome P450 2C9enzyme
AlprazolamCytochrome P450 3A5enzyme
AlprazolamCytochrome P450 3A7enzyme
AlprazolamGABA(A) Receptortarget
AlprazolamSerum albumincarrier
Alprazolamalpha1-acid glycoproteincarrier
AlprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ChlordiazepoxideGABA(A) Receptortarget
ChlordiazepoxideGABA(A) Receptor Benzodiazepine Binding Sitetarget
ChlordiazepoxideCytochrome P450 3A4enzyme
HalazepamGABA(A) Receptortarget
HalazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DiazepamCytochrome P450 3A4enzyme
DiazepamSerum albumincarrier
DiazepamCytochrome P450 2C9enzyme
DiazepamCytochrome P450 2C19enzyme
DiazepamCytochrome P450 3A5enzyme
DiazepamCytochrome P450 3A7enzyme
DiazepamP-glycoprotein 1transporter
DiazepamCytochrome P450 2B6enzyme
DiazepamProstaglandin G/H synthase 1enzyme
DiazepamCytochrome P450 2C18enzyme
DiazepamCytochrome P450 2C8enzyme
DiazepamGABA(A) Receptortarget
DiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamUDP-glucuronosyltransferase 2B15enzyme
OxazepamUDP-glucuronosyltransferase 2B7enzyme
OxazepamUDP-glucuronosyltransferase 1-9enzyme
OxazepamGABA(A) Receptortarget
OxazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamSerum albumincarrier
Ethyl loflazepateGABA(A) Receptortarget
Ethyl loflazepateGABA(A) Receptor Benzodiazepine Binding Sitetarget
BromazepamCytochrome P450 1A2enzyme
BromazepamCytochrome P450 2C19enzyme
BromazepamCytochrome P450 2E1enzyme
BromazepamGABA(A) Receptortarget
BromazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FludiazepamGamma-aminobutyric acid receptor subunit alpha-2target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-1target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-3target
FludiazepamGamma-aminobutyric acid receptor subunit alpha-5target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-1target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-2target
FludiazepamGamma-aminobutyric acid receptor subunit gamma-3target
FludiazepamGamma-aminobutyric acid receptor subunit beta-1target
FludiazepamGamma-aminobutyric acid receptor subunit beta-2target
FludiazepamGamma-aminobutyric acid receptor subunit beta-3target
FludiazepamGamma-aminobutyric acid receptor subunit deltatarget
FludiazepamGamma-aminobutyric acid receptor subunit epsilontarget
FludiazepamGamma-aminobutyric acid receptor subunit pitarget
FludiazepamGamma-aminobutyric acid receptor subunit rho-1target
FludiazepamGamma-aminobutyric acid receptor subunit rho-2target
FludiazepamGamma-aminobutyric acid receptor subunit rho-3target
KetazolamCytochrome P450 3A4enzyme
KetazolamP-glycoprotein 1transporter
KetazolamSerum albumincarrier
KetazolamGABA(A) Receptortarget
KetazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
PrazepamCytochrome P450 3A4enzyme
PrazepamGABA(A) Receptortarget
PrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MedazepamGABA(A) Receptortarget
MedazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
NordazepamGABA(A) Receptortarget
NordazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FluvoxamineSodium-dependent serotonin transportertarget
FluvoxamineCytochrome P450 1A2enzyme
FluvoxamineCytochrome P450 2D6enzyme
FluvoxamineCytochrome P450 2C9enzyme
FluvoxamineCytochrome P450 2C19enzyme
FluvoxamineCytochrome P450 1A1enzyme
FluvoxamineCytochrome P450 3A4enzyme
FluvoxamineCytochrome P450 3A Subfamilyenzyme
FluvoxamineP-glycoprotein 1transporter
FluvoxamineCytochrome P450 2B6enzyme
FluvoxaminePotassium voltage-gated channel subfamily H member 2target
FluvoxamineBile salt export pumptransporter
PregabalinExcitatory amino acid transporter 3transporter
PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
PregabalinLarge neutral amino acids transporter small subunit 1transporter
TemazepamCytochrome P450 3A4enzyme
TemazepamCytochrome P450 2B6enzyme
TemazepamCytochrome P450 2C9enzyme
TemazepamGABA(A) Receptortarget
TemazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
Clorazepic acidCytochrome P450 3A4enzyme
Clorazepic acidGABA(A) Receptortarget
Clorazepic acidGABA(A) Receptor Benzodiazepine Binding Sitetarget
Trazodone5-hydroxytryptamine receptor 2Atarget
TrazodoneSodium-dependent serotonin transportertarget
TrazodoneAlpha-1A adrenergic receptortarget
TrazodoneAlpha-2A adrenergic receptortarget
TrazodoneHistamine H1 receptortarget
Trazodone5-hydroxytryptamine receptor 1Atarget
TrazodoneCytochrome P450 2D6enzyme
TrazodoneCytochrome P450 3A4enzyme
Trazodone5-hydroxytryptamine receptor 2Ctarget
TrazodoneCytochrome P450 3A5enzyme
TrazodoneCytochrome P450 3A7enzyme
TrazodoneP-glycoprotein 1transporter
Trazodone5-hydroxytryptamine receptor 1Ctarget
MidazolamCytochrome P450 3A4enzyme
MidazolamCytochrome P450 3A5enzyme
MidazolamUDP-glucuronosyltransferase 1-4enzyme
MidazolamCytochrome P450 3A7enzyme
MidazolamGABA(A) Receptortarget
MidazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MidazolamP-glycoprotein 1transporter
MidazolamSerum albumincarrier
MidazolamAlpha-1-acid glycoprotein 1carrier
MidazolamAdenosine receptor A2atarget
MidazolamExcitatory amino acid transporter 2transporter
MidazolamUDP-glucuronosyltransferase 2B7enzyme
MidazolamUDP-glucuronosyltransferase 2B4enzyme
FlurazepamCytochrome P450 3A4enzyme
FlurazepamP-glycoprotein 1transporter
FlurazepamCytochrome P450 2E1enzyme
FlurazepamCytochrome P450 2A6enzyme
FlurazepamSolute carrier family 22 member 2transporter
FlurazepamGABA(A) Receptortarget
FlurazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TranylcypromineAmine oxidase [flavin-containing] Btarget
TranylcypromineAmine oxidase [flavin-containing] Atarget
TranylcypromineCytochrome P450 2C19enzyme
TranylcypromineCytochrome P450 2A6enzyme
TranylcypromineCytochrome P450 2D6enzyme
TranylcypromineCytochrome P450 1A2enzyme
TranylcypromineCytochrome P450 2C9enzyme
TranylcypromineCytochrome P450 3A4enzyme
TriazolamCytochrome P450 3A4enzyme
TriazolamCytochrome P450 3A5enzyme
TriazolamCytochrome P450 3A7enzyme
TriazolamCytochrome P450 2C8enzyme
TriazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TriazolamGABA(A) Receptortarget
Ondansetron5-hydroxytryptamine receptor 3Atarget
OndansetronCytochrome P450 3A4enzyme
OndansetronCytochrome P450 1A2enzyme
OndansetronCytochrome P450 2D6enzyme
OndansetronCytochrome P450 3A5enzyme
OndansetronCytochrome P450 3A7enzyme
Ondansetron5-hydroxytryptamine receptor 4target
Ondansetron5-hydroxytryptamine receptor 1Atarget
Ondansetron5-hydroxytryptamine receptor 1Btarget
OndansetronMu-type opioid receptortarget
OndansetronCytochrome P450 2C9enzyme
OndansetronCytochrome P450 2E1enzyme
ChlormezanoneTranslocator proteintarget
EstazolamCytochrome P450 3A4enzyme
EstazolamGABA(A) Receptortarget
EstazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FlunitrazepamCytochrome P450 2C19enzyme
FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
FlunitrazepamCytochrome P450 2A6enzyme
FlunitrazepamCytochrome P450 2B6enzyme
FlunitrazepamCytochrome P450 2C9enzyme
FlunitrazepamCytochrome P450 3A4enzyme
FlunitrazepamCytochrome P450 2E1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
FlunitrazepamGABA(A) Receptortarget
FlunitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxprenololBeta-1 adrenergic receptortarget
OxprenololBeta-2 adrenergic receptortarget
OxprenololSolute carrier family 22 member 2transporter
OxprenololCytochrome P450 2D6enzyme
OxprenololBeta-3 adrenergic receptortarget
NitrazepamSodium channel protein type 1 subunit alphatarget
NitrazepamCytochrome P450 3A4enzyme
NitrazepamCytochrome P450 2E1enzyme
NitrazepamGABA(A) Receptortarget
NitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
7-NitroindazoleNitric oxide synthase, endothelialtarget
7-NitroindazoleNitric oxide synthase, inducibletarget
7-NitroindazoleNitric oxide synthase, braintarget
Deramciclane5-hydroxytryptamine receptor 2Atarget
Deramciclane5-hydroxytryptamine receptor 2Ctarget
DeramciclaneCytochrome P450 2D6enzyme
AdipiplonGABA(A) Receptor Benzodiazepine Binding Sitetarget
VortioxetineSodium-dependent serotonin transportertarget
Vortioxetine5-hydroxytryptamine receptor 3Atarget
Vortioxetine5-hydroxytryptamine receptor 7target
Vortioxetine5-hydroxytryptamine receptor 1Btarget
Vortioxetine5-hydroxytryptamine receptor 1Atarget
VortioxetineBeta-1 adrenergic receptortarget
VortioxetineSodium-dependent noradrenaline transportertarget
VortioxetineCytochrome P450 2D6enzyme
VortioxetineCytochrome P450 3A4enzyme
VortioxetineCytochrome P450 3A5enzyme
VortioxetineCytochrome P450 2C19enzyme
VortioxetineCytochrome P450 2C9enzyme
VortioxetineCytochrome P450 2A6enzyme
VortioxetineCytochrome P450 2C8enzyme
VortioxetineCytochrome P450 2B6enzyme
DoramectinCytochrome P450 3A4enzyme
GepironeCytochrome P450 3A4enzyme
Gepirone5-hydroxytryptamine receptor 1Atarget
Ritanserin5-hydroxytryptamine receptor 2Atarget
RitanserinCytochrome P450 2D6enzyme
LoprazolamGABA(A) Receptortarget
LoprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamCytochrome P450 2C19enzyme
ClobazamCytochrome P450 3A4enzyme
ClobazamCytochrome P450 2B6enzyme
ClobazamCytochrome P450 2C18enzyme
ClobazamP-glycoprotein 1transporter
ClobazamGABA(A) Receptortarget
ClobazamCytochrome P450 2D6enzyme
ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamSerum albumincarrier
ClobazamAlpha-1-acid glycoprotein 1carrier
ClobazamCytochrome P450 2C9enzyme
ClobazamUDP-glucuronosyltransferase 1-4enzyme
ClobazamUDP-glucuronosyltransferase 1-6enzyme
ClobazamUDP-glucuronosyltransferase 2B4enzyme
ClobazamUDP-glucuronosyltransferase 1-1enzyme
ClobazamCytochrome P450 1A2enzyme
ClobazamCytochrome P450 2C8enzyme
ClobazamCytochrome P450 3A5enzyme
ClobazamCytochrome P450 3A7enzyme
AdinazolamCytochrome P450 2C19enzyme
AdinazolamCytochrome P450 3A4enzyme
AdinazolamGABA(A) Receptortarget
AdinazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
HydroxyzineHistamine H1 receptortarget
HydroxyzineCytochrome P450 2D6enzyme
HydroxyzineCytochrome P450 3A4enzyme
HydroxyzineCytochrome P450 3A5enzyme
HydroxyzinePotassium voltage-gated channel subfamily H member 2target
HydroxyzineP-glycoprotein 1transporter
HydroxyzineSerum albumincarrier
CamazepamGABA(A) Receptortarget
CamazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
CloxazolamGABA(A) Receptortarget
CloxazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClotiazepamCytochrome P450 2B6enzyme
ClotiazepamCytochrome P450 2C18enzyme
ClotiazepamCytochrome P450 2C19enzyme
ClotiazepamCytochrome P450 3A4enzyme
ClotiazepamGABA(A) Receptortarget
ClotiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TofisopamcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
TofisopamcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
TofisopamcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TofisopamcGMP-dependent 3',5'-cyclic phosphodiesterasetarget
TofisopamCytochrome P450 3A4enzyme
Captodiame5-hydroxytryptamine receptor 2Ctarget
CaptodiameSigma non-opioid intracellular receptor 1target
CaptodiameDopamine D3 receptortarget
EtizolamCytochrome P450 3A4enzyme
EtizolamCytochrome P450 2C18enzyme
EtizolamCytochrome P450 2C19enzyme
EtizolamPlatelet-activating factor receptortarget
EtizolamGABA(A) Receptortarget
EtizolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
PinazepamGABA(A) Receptortarget
PinazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
Mirtazapine5-hydroxytryptamine receptor 2Atarget
Mirtazapine5HT3 serotonin receptortarget
MirtazapineAlpha-2A adrenergic receptortarget
Mirtazapine5-hydroxytryptamine receptor 2Ctarget
MirtazapineKappa-type opioid receptortarget
MirtazapineHistamine H1 receptortarget
MirtazapineCytochrome P450 1A2enzyme
MirtazapineCytochrome P450 3A4enzyme
MirtazapineCytochrome P450 2D6enzyme
MirtazapineAlpha-1 adrenergic receptorstarget
MirtazapineSodium-dependent serotonin transportertransporter
EsmirtazapineCytochrome P450 2D6enzyme
EsmirtazapineHistamine H1 receptortarget
Esmirtazapine5-hydroxytryptamine receptor 2target
EsmirtazapineAlpha-2 adrenergic receptorstarget
ButriptylineSodium-dependent serotonin transportertarget
ButriptylineHistamine H1 receptortarget
Butriptyline5-hydroxytryptamine receptor 2Atarget
BentazepamGABA(A) Receptortarget
BentazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MexazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MexazolamCytochrome P450 3A4enzyme
MexazolamGABA(A) Receptortarget