- Anti-Anxiety Agents
- Accession Number
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
- ATC Classification
Drug Drug Description Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Ethyl loflazepate Not Available Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Fludiazepam Used for the short-term treatment of anxiety disorders. Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Etifoxine A benzoxazine class drug primarily used as an anxiolytic, but that also possesses neuroprotective, neuroplastic, and anti-inflammatory properties; these effects are thought to arise due to modulation of GABAergic neurotransmission and neurosteroid synthesis. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Triazolam A benzodiazepine used for short term treatment of insomnia. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Estazolam A benzodiazepine used for the short-term management of insomnia. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. 7-Nitroindazole Not Available Deramciclane Investigated for use/treatment in anxiety disorders. Adipiplon Investigated for use/treatment in insomnia and sleep disorders. Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Imagabalin Imagabalin has been investigated in Generalized Anxiety Disorder. Gepirone A serotonin receptor agonist used to treat major depressive disorder in adults Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Mebicar Not Annotated Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... MRK-409 MRK-409 is a GABA-A receptor agonist . Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Adinazolam For the treatment of anxiety and status epilepticus. Hydroxyzine An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria. Camazepam Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression. Cloxazolam Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to... Clotiazepam A thienodiazepine used to manage anxiety disorders and insomnia. Mebutamate Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a... Tofisopam For the treatment of anxiety and alcohol withdrawal. Captodiame Captodiame is indicated for the treatment of anxiety. Benzoctamine Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be... Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Pinazepam A benzodiazepine indicated in the treatment of anxiety and severe insomnia. Gedocarnil Not Annotated Emylcamate Not Annotated Fabomotizole Not Annotated Mephenoxalone A muscle relaxant indicated in the treatment of painful muscle spasms and cramps. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Bentazepam Not Annotated Mexazolam A benzodiazepine indicated to treat anxiety with or without psychoneurotic conditions. ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.
- Drugs & Drug Targets