Actinic Keratosis (AK) (DBCOND0065881)

Identifiers

Synonyms
Actinic Keratosis / Solar keratosis / Keratosis, Actinic / Actinic Keratoses / Senile keratoma / Actinic keratosis (morphologic abnormality) / Senile keratosis / Disseminated superficial actinic porokeratosis (disorder) / Actinic cheilitis / Actinic cheilitis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Diclofenac
An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
Fluorouracil
A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
Hyaluronic acid
A glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.
Ingenol mebutate
A topical agent used for the treatment of actinic keratosis.
Nitrogen
A cryogenic agent used to treat various benign and malignant skin lesions.
No drug targets
Salicylic acid
An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03116698
A Study to Evaluate Two Concentrations of DFD-07 Cream, in Subjects With Actinic Keratosis (AK) of the Face and/or Scalp Over a 12-week Treatment PeriodNo drug interventionstreatment2 / 3completed
NCT01926496
Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5%treatment4completed
NCT03727074
Bioequivalence Study to Compare Sol-Gel Technologies' 5-FU Cream With Efudex® (5-FU) Creamtreatment3completed
NCT02406014
Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalptreatment4completed
NCT03285490
A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on Actinic Keratosis on Face or Scalp (AK004)treatment3completed
NCT02990221
Efficacy of Ingenol Mebutate on Actinic Keratoses and Field Cancerization vs Cryotherapytreatment4completed
NCT01265602
Double-blind, Randomized, Vehicle- and Comparator-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of LAS41007 in the Treatment of Actinic KeratosisNo drug interventionstreatment3completed
NCT02239679
Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapytreatment2completed
NCT01962987
A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® (Diclofenac Sodium) Gel 3% in the Treatment of Actinic Keratosistreatment3completed
NCT02124733
Protocols for Painless Photodynamic Therapy (PDT) of Actinic KeratosesNo drug interventionstreatment3completed
NCT00308854
Photodynamic Therapy With PD P 506 A Compared With Placebo-PDT for the Treatment of AKNo drug interventionstreatment3completed
NCT03538951
Study to Evaluate the Efficacy, Safety, and Tolerability of Topical VDA-1102 Ointment in Subjects With Actinic KeratosisNo drug interventionstreatment2completed
NCT00915551
A Multi-Center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)treatment3completed
NCT01358851
LAS41005 in Hyperkeratotic Actinic KeratosisNo drug interventionstreatment2completed
NCT02647151
Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Geltreatment4unknown_status
NCT01541553
A Sequential Treatment Regimen of Cryotherapy and Picato® for the Treatment of Actinic Keratosis on the Face and Scalptreatment3completed
NCT02844777
Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic KeratosisNo drug interventionstreatment2completed
NCT02242747
Safety and Tolerability Study of Ingenol Mebutate Compared to 5-FU to Treat Facial Actinic KeratosistreatmentNot Availablecompleted
NCT00894647
Safety and Effectiveness Study of Actinic Keratosis Treatment Following Cryosurgerytreatment3completed
NCT03013647
Daylight Photodynamic Therapy for Actinic Keratosis and Skin Field CancerizationtreatmentNot Availableunknown_status
NCT02120898
A Study to Evaluate the Safety and Efficacy Imiquimod Cream, 2.5% in Participants With Actinic Keratosestreatment3completed
NCT02248298
Efficacy of AFL-assisted PDT With Short Incubation Time in Actinic KeratosisNo drug interventionstreatment1completed
NCT02952898
Study Comparing GDC 695 and Diclofenac Sodium Gel, 3% in Subjects With Actinic Keratosestreatment3completed
NCT02600598
Biological Effects of LEO 43204 in Actinic Keratosistreatment1completed
NCT00603798
Safety and Effectiveness Study of Imiquimod Creams for the Treatment of Actinic Keratoses (AKs)treatment3completed
NCT02337205
Ph 1, Single-Center, Safety, Tolerability & Pharmacokinetic Study of KX2 391 Ointment in Subj. w Actinic Keratosistreatment1completed
NCT00859105
A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled Therapeutic Equivalence Study of Three Imiquimod Cream 5% Treatments for Patients With Actinic Keratosistreatment3completed
NCT00544297
A Study to Examine the Safety and Toleration of PEP005 Topical Gel in Patients With Actinic Keratoses on the Top of the Handtreatment2completed
NCT00952783
A Long Term Follow up Study of Patients Who Have Completed the PEP005-020 StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02325661
Open Uncontrolled Validation Study for the German Version of the Actinic Keratosis Quality of Life Questionnaire (AKQoL)No drug interventionsNot AvailableNot Availablecompleted
NCT02838628
Activity & Safety Study of KX2-391 Ointment in Participants With Actinic Keratosis on the Face or Scalptreatment2completed
NCT01541228
Photodynamic Treatment of Actinic Keratoses With Different Light DosesNo drug interventionstreatmentNot Availablecompleted
NCT00850811
A Study to Evaluate the Photoirritation Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteerstreatment1completed
NCT00659893
Safety and Toleration of PEP005 Topical Gel When Applied to a Treatment Area of up to 100cm2treatment1completed
NCT01203878
Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapytreatment4terminated
NCT01703078
Safety and Tolerability of Different Concentrations of an Ingenol Derivative Field Therapy in the Treatment of Actinic KeratosisNo drug interventionstreatment1completed
NCT00695578
Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapytreatment4completed
NCT02305888
Safety of LEO 43204 for Actinic Keratosis Applied on Face/Chest, Scalp and Trunk/Extremities, Respectivelytreatment2completed
NCT01788007
Clinical Study to Evaluate the Bioequivalence of Two Imiquimod Cream 3.75% Formulations in Patients With Actinic Keratosis.treatment1completed
NCT01151956
Imiquimod and Actinic Keratoses: an Observational StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02120456
Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosistreatment1 / 2completed
NCT03508856
Clinical and Histologic Evaluation of Picato 0.15% Gel in the Cosmetic Improvement of Photoaged SkintreatmentNot Availablecompleted
NCT02137785
Safety and Efficacy Study of Photodynamic Therapy With Levulan Kerastick + Blue Light for Actinic Keratoses on the Upper Extremitiestreatment3completed
NCT02938715
Pilot Study of the Pragmatic Use of Mobile Phone Based Follow up of Actinic Keratoses Treated With Topical 5-fluorouracilNo drug interventionsotherNot Availablecompleted
NCT01812837
The Use of Microneedles in Photodynamic TherapytreatmentNot Availablecompleted
NCT03805737
Indoor Daylight Photo Dynamic Therapy for Actinic KeratosisNo drug interventionstreatmentNot Availablecompleted
NCT01892137
Histological Confirmation of Clinical Clearance of Actinic Keratoses Following Treatment With Ingenol Mebutate Gel, 0.05%treatment1completed
NCT00953732
A Long Term Follow up Study of Patients Who Have Completed the PEP005-016 or PEP005-025 StudiesNo drug interventionsNot AvailableNot Availablecompleted
NCT00926952
Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusiontreatment3completed
NCT02362152
The Real Life Topical Field Treatment of Actinic Keratosis StudyNot AvailableNot Availablecompleted
NCT02549352
Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-uptreatment3completed
NCT00306800
Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and ScalpNo drug interventionstreatment3completed
NCT03110159
DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipientstreatment1 / 2completed
NCT03083470
Study of SOR007 Ointment for Actinic Keratosistreatment2completed
NCT01735942
Ingenol Mebutate Compared to Cryotherapy for the Treatment of Skin Lesionstreatment0withdrawn
NCT00917306
A Multi-center Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on Non-head Locations (Trunk and Extremities)treatment3completed
NCT01898936
Fractional Laser-assisted Daylight Photodynamic Therapy Versus Daylight Photodynamic for Treatment of Actinic KeratosesNo drug interventionstreatmentNot Availablecompleted
NCT01571336
Photodynamic Therapy of Actinic Keratoses With Alacare®No drug interventionsNot AvailableNot Availablecompleted
NCT01000636
Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)No drug interventionsother4completed
NCT02100813
Safety and Efficacy of Doses of LEO 43204 Once Daily for Two Consecutive Days on Full Balding Scalp in Subjects With Actinic Keratosistreatment1 / 2completed
NCT01449513
PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by Reflectance Confocal MicroscopyNot Available1completed
NCT02385318
To Compare Safety and Efficacy of Perrigo's Drug Product Compared to an FDA Approved Drug Product in the Treatment of Actinic Keratosistreatment3completed
NCT02654717
Eight Week Study of Treatment With DFD-07 for Actinic Keratosis of the Face and ScalpNo drug interventionstreatment2completed
NCT02559934
Multiple-dose Pharmacokinetic Study of Solamargine in Patients With Actinic Keratosistreatment1completed
NCT02361216
Efficacy and Safety of Ingenol Mebutate Gel for Actinic Keratosis Applied on Large Area on Face, Scalp or Chesttreatment3completed
NCT01583816
Dose-finding, Safety, Efficacy Trial of Topical Resiquimod in Patients With Multiple Actinic Keratosis Lesionstreatment2completed
NCT05900258
Tirbanibulin 1% Ointment for the Treatment of Chronically Sun-damaged Skin on the Facetreatment4completed
NCT00304239
Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalptreatment3completed
NCT02549339
Efficacy and Safety of LEO 43204 in the Field Treatment of Actinic Keratosis on Face or Chest including12-month Follow-uptreatment3completed
NCT00375739
Study to Determine the Safety of PEP005 0.025% and 0.05% Topical Gel in Patients With Actinic Keratosestreatment2completed
NCT02124239
Pharmacokinetics of Ingenol Mebutate Gel in Actinic Keratosis Under Maximum Use Conditionstreatment1completed
NCT02902822
Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of BergamoNo drug interventionsdiagnosticNot Availablecompleted
NCT02867722
Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses in the Northeast United StatestreatmentNot Availablewithdrawn
NCT02799030
A Clinical Trial of Topical Photodynamic Therapy With 5-aminolevulinic Acid for the Treatment of Actinic Keratosistreatment2completed
NCT02473848
Ingenol Mebutate Gel 0.05% in Kidney Transplant Recipients With Actinic Keratosestreatment3terminated
NCT01656226
Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic KeratosisNo drug interventionstreatment4unknown_status
NCT00269074
Effect of IDEA-070 on Pain and Inflammation Induced by PDTNo drug interventionstreatment2completed
NCT00294320
Evaluation of Two Different Non-invasive Techniques to Monitor the Clearance of Actinic Keratosis Lesionsdiagnostic3completed
NCT02799082
Evaluation of Efficacy and Safety of BF-200 ALA Used With Photodynamic Therapy in Patients With Actinic Keratosis.treatment3completed
NCT00110682
Study of Imiquimod 5% Cream in Addition to Cryotherapy in the Management of Actinic Keratosestreatment4completed
NCT00777127
Long-term Effects of Imiquimod and Diclofenac in Actinic Keratosestreatment4completed
NCT04552327
5% KOH Solution vs. Placebo and Diclofenac Gel for the Treatment of Actinic Keratosistreatment3completed
NCT03115476
A Trial to Compare the Incidence of Squamous Cell Carcinoma (SCC) and Other Skin Neoplasia on Skin Areas Treated With Ingenol Disoxate Gel or Vehicle Gel for Actinic Keratosis on Face and Chest or Scalpprevention3terminated
NCT01820260
Safety and Efficacy of Ingenol Mebutate Once Daily for 2 or 3 Consecutive Days in Subjects With Actinic Keratosistreatment1 / 2completed
NCT03024060
Phase 3 Study of Levulan With New Blue Light for AK on the Face or Scalptreatment3withdrawn
NCT06319794
Study on the Safety and Efficacy of Bimiralisib Gel in Participants Suffering From Actinic Keratosistreatment2recruiting
NCT05741294
A Study of Tirbanibulin on the Wellbeing of Participants With Actinic Keratosestreatment4completed
NCT00089180
T4N5 Liposomal Lotion in Preventing The Recurrence of Nonmelanoma Skin Cancer in Patients Who Have Undergone a Kidney Transplantprevention2completed
NCT05231044
A Multi-Center Study to Evaluate the Efficacy and Safety of KX01 Ointment 1% on Actinic Keratosis on Face or ScalpNo drug interventionstreatment3completed
NCT01405144
5fluorouracil for Advanced PhotoagingNo drug interventionstreatment3unknown_status
NCT03643744
Photodynamic Therapy-Induced Immune Modulation: Part IIIprevention1completed
NCT03210740
Safety and Efficacy Study of AM001 Cream in the Treatment of Actinic KeratosisNo drug interventionstreatment2completed
NCT02616601
Multicenter, Double-blind, Placebo Controlled Comparing Test Fluorouracil Cream to Carac Cream in Actinic Keratosistreatment3completed
NCT05688904
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapyother1recruiting
NCT02654769
A Study of Equivalence of Generic Ingenol Mebutate Gel 0.05% and Picato Gel 0.05% in Subjects With Actinic Keratosistreatment3completed
NCT02799069
Evaluation of Safety and Efficacy of BF-200 ALA for the Treatment of Actinic Keratosis With Photodynamic Therapytreatment3completed
NCT00987246
Study on the Efficacy of LAS41005 in the Treatment of Actinic KeratosisNo drug interventionstreatment3completed
NCT03200912
An Equivalence Study of Generic Ingenol Mebutate Gel 0.015% and Picato Gel 0.015% in Subjects With Actinic Keratosistreatment3completed
NCT02632110
Microneedle Lesion Preparation Prior to Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) for AK on Facetreatment2completed
NCT02459795
To Compare Safety and Efficacy of Perrigo's Drug Compared to an FDA Approved Drug in the Treatment of Actinic Keratosistreatment3completed
NCT02085395
Clinical Study Assessment of SR-T100 Topical Gel Against Actinic KeratosisNo drug interventionstreatment2completed
NCT02716714
Clinical Trial of Ingenol Mebutate Gel 0.015% & 0.05% in Actinic Keratosistreatment4completed
NCT01600014
Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalptreatment3completed
NCT04779255
Pain Management During a Photodynamic Therapy Session on the Vertex for Actinic Keratosis: Tumescent Anesthesia InteresttreatmentNot Availableunknown_status
NCT02670655
Efficacy of Iontophoresis-assisted AFL-PDT in Actinic Keratosistreatment1completed
NCT01922050
A Study of Increasing Strengths, Safety and Efficacy of Two Formulas of LEO 43204 on the Face or the Chest in Patients With Actinic Keratosistreatment1 / 2completed
NCT05699603
Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipientsprevention2recruiting
NCT01493921
Efficacy Study & Safety Evaluation of SR-T100 Gel in Actinic Keratosis TreatmentNo drug interventionstreatment3completed
NCT01998984
Efficacy and Safety of Ingenol Mebutate Gel 0.06% When Applied Once Daily for 2, 3 or 4 Consecutive Days to a Treatment Area of Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosistreatment2completed
NCT04396184
Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Actinic KeratosisNo drug interventionstreatmentNot Availableunknown_status
NCT01453179
Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2)treatment4completed
NCT00335179
Cellular and Molecular Events During Treatment of Actinic Keratosis With Imiquimod 5% Creamtreatment2completed
NCT01260987
Fractional CO2 Laser Assisted Photodynamic TherapyNo drug interventionstreatment2 / 3completed
NCT02547233
Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Face or Chest Including 12-month Follow-uptreatment3completed
NCT03319251
Biomarker Database Registry for Photodynamic TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT01803477
Safety and Dose Finding Study of New Vehicle Formulations Containing Ingenol Mebutate to Treat Actinic Keratosis on the Forearmtreatment1 / 2completed
NCT04202445
TreatMent of ActInic KerAtosis Lesions : pharmacoepiDemiological Study of the Impact in Real Life of ingenOl Mebutate Gel (Picato®) on Patients SatisfactionNot AvailableNot Availablecompleted
NCT02650505
A Clinical Study to Evaluate the Sensitizing Potential of LEO 43204 Gelother1completed
NCT02424305
Pharmacokinetics of LEO 43204 Gel in Actinic Keratosis Administered Under Maximal Use Conditionstreatment1completed
NCT01787383
A Simultaneous Treatment Regimen Compared to a Sequential Treatment Regimen With Ingenol Mebutate Gel 0.015% and 0.05% of Two Areas With Actinic Keratosis on Face/Scalp and Trunk/Extremitiestreatment3completed
NCT01806961
Observational Trial Tolerability and Efficacy of Resiquimod Gel in Patients Treated for Actinic Keratosis.No drug interventionsNot AvailableNot Availableterminated
NCT02278861
Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosisprevention2completed
NCT00991861
Efficacy and Safety Study of LAS41007 in the Treatment of Actinic KeratosisNo drug interventionstreatment2completed
NCT00814528
Photodynamic Therapy Mediated by Topical Application of 5- ALA for the Treatment of Actinic KeratosestreatmentNot Availablewithdrawn
NCT01387711
PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by HistologyNot Available1completed
NCT01459393
Comparison Between 5-aminolevulinic Acid Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis Treatmenttreatment3completed
NCT02421471
PMS to Evaluate the Safety and Efficacy of Picato® GelNot AvailableNot Availablecompleted
NCT03731988
Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy According to the Laser Density for Actinic Keratosistreatment4completed
NCT00696488
Measuring Adherence To Topical 5-Fluorouracil in a Clinic Populationtreatment4completed
NCT05152407
MRB 0.3% Serum Effectiveness on 2 Early Clinical Markers of Photoinduced Cutaneous Aging: Actinic Lentigo and Actinic KeratosisNo drug interventionstreatmentNot Availableunknown_status
NCT02464709
Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL)treatment4completed
NCT03006185
Laser and Microdermabrasion Before Photodynamic Therapy for Actinic Keratoses in Field-cancerized SkinNo drug interventionstreatment2completed
NCT01516515
Efficacy and Safety Phase II Study of SR-T100 to Treat Actinic KeratosisNo drug interventionstreatment2completed
NCT05060237
Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and ScalpNo drug interventionstreatment1completed
NCT00852137
A Study to Evaluate the Pharmacokinetics of PEP005 (Ingenol Mebutate) Gel, 0.05%, When Applied in a Maximal Use Setting to the Dorsal Aspect of the Forearm in Patients With Actinic Keratosistreatment2completed
NCT01686152
Study Comparing Imiquimod Cream, 3.75% to Zyclara® (Imiquimod) Cream, 3.75% in the Treatment of Actinic Keratosisother3completed
NCT02759900
Using a Cold Atmospheric Plasma Device to Treat Skin DisordersNo drug interventionstreatmentNot Availablerecruiting
NCT00472459
PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin CancerNo drug interventionsprevention3completed
NCT02126670
ACT01 in Combination With Comp01-04 in Patients With Actinic KeratosisNo drug interventionstreatment2completed
NCT00916006
A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)treatment3completed
NCT02594436
The Use of Picato® (Ingenol Mebutate) to Treat Actinic Keratosis in Standard Clinical PracticeNot AvailableNot Availablecompleted
NCT00989313
A Long Term Follow up Study of Patients Who Have Complete Clearance of Their Actinic Keratosis (AK) Lesions at the Day 57 Visit in the PEP005-028 StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06027619
Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratosestreatment2active_not_recruiting
NCT01229319
Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratosestreatment4unknown_status
NCT03037541
Cryosurgery and Cream Combination for Actinic Keratosistreatment3completed
NCT03914417
Genomic Markers Before and After Treatment of Actinic Keratosis With Imiquimod 3.75% Creamtreatment2completed
NCT01742663
A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® Gel 3% in the Treatment of Actinic Keratosistreatment1completed
NCT02150863
Treatment of Field Cancerization for Reduction in Tumor Burden - A Prospective StudyNo drug interventionstreatmentNot Availableterminated
NCT00700063
A Multicenter Study to Evaluate the Safety and Efficacy of PEP005 Topical Gel When Used to Treat Actinic Keratoses on the Head (Face or Scalp)treatment2completed
NCT01413763
Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic KeratosisNot Available4unknown_status
NCT02547363
Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-uptreatment3completed
NCT01302925
PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy SubjectsNot Available1completed
NCT02674048
Metvix Daylight PDT in Actinic KeratosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03122457
Perimenstrual Acne With Clindamycin Phosphate and Benzoyl Peroxidetreatment2completed
NCT02029066
Pharmacokinetic Study of Solamargine in Patients With Actinic KeratosisNo drug interventionsNot Available1completed
NCT02090465
Assessment of Treatment Success and Quality of Life in Patients With Actinic Keratoses Under Therapy With Ingenol Mebutate in a Period of 8 WeeksNot AvailableNot Availablecompleted
NCT00107965
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Actinic Keratosestreatment2completed
NCT01966120
Safety and Efficacy Study for the Field-directed Treatment of Actinic Keratosis (AK) With Photodynamic Therapy (PDT)treatment3completed
NCT02878382
Potential Impact of Patient Vitamin D Status in AK Response to MAL-PDTNo drug interventionstreatmentNot Availablecompleted
NCT03327831
Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratosestreatment4completed
NCT02354391
Ingenol Mebutate (Picato®) With Methyl Aminolevulinate Photodynamic Therapy for the Treatment of Actinic Keratosistreatment2unknown_status
NCT01905891
Nanocytology Test to Evaluate Skin Cancer in High Risk PatientsNo drug interventionshealth_services_researchNot Availablecompleted
NCT01611480
Efficacy and Safety of a New Topical Formulation With Imiquimod (Limtop) Applied 1, 3 or 7 Times Weekly During 2 x 2 Weeks Treatment for Actinic Keratosis on the HeadNot Available2completed
NCT01525329
Combination Therapy With 5-Fluorouracil and Photodynamic Therapy in Post-transplant Premalignant Skin Diseasetreatment3terminated
NCT02404389
Safety, Tolerability, and Efficacy Study of LFX453 in Actinic Keratosis PatientsNo drug interventionstreatment2completed
NCT01444989
Development and Validation of a Quality of Life Instrument for Actinic KeratosisNo drug interventionsotherNot Availablecompleted
NCT00710489
Potential Research Study Participant RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT04140292
Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratosestreatment2completed
NCT00308867
PD P 506 A-PDT Versus Placebo-PDT and Cryosurgery for the Treatment of AKNo drug interventionstreatment3completed
NCT01836367
Ingenol Mebutate 0.015% Gel in the Treatment of Actinic Keratoses (AK) on the Face and ScalpNot Available1completed
NCT00189267
A Study to Evaluate the Effectiveness and Safety of Multiple Applications of Imiquimod 5% Cream for the Treatment of Actinic Keratoses in Organ Transplant Recipientstreatment2completed
NCT02611804
A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled, Multicenter Study Comparing Diclofenac Sodium Gel, 3% to Solaraze® Gel, 3% in the Treatment of Actinic Keratosis on the Face or Bald Scalpother3completed
NCT03684772
Topical Ionic Contra-Viral Therapy in Actinic Keratosistreatment2unknown_status
NCT02984072
Menthol for PDT Pain Relieftreatment4completed
NCT02289768
Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratosestreatment3completed
NCT00828568
Bioequivalence Study of Two Imiquimod Cream 5%treatment1completed
NCT02209012
Twelve Month Follow-Up of CP0108Not AvailableNot Availablecompleted
NCT00850681
A Study to Evaluate the Photoallergic Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteerstreatment1completed
NCT02866695
Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipientstreatment4completed
NCT02019355
Actinic Keratosis Studytreatment0completed
NCT01481155
Comparative Study of Photodynamic Therapy vs. CO2 Laser Therapy in Treatment of Actinic KeratosesNo drug interventionstreatmentNot Availableunknown_status
NCT01475955
Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)treatment2completed
NCT02446223
Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015%No drug interventionstreatment4completed
NCT00843323
Photodynamic Therapy (PDT) Effect on Large Surface Photodamaged SkinNo drug interventionstreatmentNot Availablecompleted
NCT03697590
Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior CurettageNo drug interventionstreatment4completed
NCT02813902
A Trial of Polypodium Leucotomos in Preventing Skin Cancer and Its PrecursorsNo drug interventionshealth_services_research1withdrawn
NCT01458587
Levulan PDT Versus Vehicle for Extremity Actinic Keratoses (AK)treatment2completed
NCT02644187
Pain Relief During Photodynamic Therapy for Actinic Keratoses With a New Irradiation ProtocoltreatmentNot Availablecompleted
NCT06014697
OCT and Invasion in Cutaneous Skin LesionsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03076918
Evaluating the Device FLEXITHERALIGHT Compared to the Conventional Photodynamic TherapyNo drug interventionstreatmentNot Availableterminated
NCT05387525
A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalptreatment4recruiting
NCT02281682
IM Versus 5-FU Versus IMI Versus MAL-PDT in Treatment of Actinic Keratosistreatment4unknown_status
NCT05279131
A Study to Evaluate the Safety and Tolerability of Tirbanibulin Ointment 1% in Adult Participants With Actinic Keratosistreatment3completed
NCT05481073
UV Sensor in Patients With Actinic KeratosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05260073
Patient and Clinician Reported Outcomes for Tirbanibulin Effectiveness and Safety in Actinic KeratosisNot AvailableNot Availablecompleted
NCT03076892
Evaluation of Non-inferiority and Tolerability of the Device PHOS-ISTOSNo drug interventionstreatmentNot Availablecompleted
NCT02594644
The Use of Microneedles to Expedite Treatment Time in Photodynamic TherapytreatmentNot Availablecompleted
NCT05356572
A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty SkinNo drug interventionstreatmentNot Availablecompleted
NCT04269395
A Study to Assess Recurrence of Actinic Keratosis in Participants Treated With Methyl Aminolevulinate Hydrochloride Cream or Vehicle Cream Who Achieved Complete Response to Treated Lesions in Earlier StudyNo drug interventionsprevention3terminated
NCT06135415
A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic Keratosistreatment3recruiting
NCT05636800
Microwave Treatment for Actinic KeratosisNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02628236
Maximal Use Systemic Exposure Study of Levulan Kerastick (MUSE 2)other2completed
NCT02281136
Maximal Use Systemic Exposure (MUSE) Study of Levulan KerastickNot Available2completed
NCT04329221
Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipientsprevention2not_yet_recruiting
NCT03963102
Duration of Ameluz Application in Acral Actinic Keratoses Responsetreatment4terminated
NCT04642287
Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipientstreatment2not_yet_recruiting
NCT00774787
Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratosestreatment4completed
NCT02062853
Continuous Quality Improvement (CQI) Pilot Study Evaluating the Utility of an Educational VideoNo drug interventionshealth_services_researchNot Availablecompleted
NCT03285477
A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalptreatment3completed
NCT05976061
High- and Low-risk Actinic Keratosis Referrals to Secondary CareNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03279328
Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agentstreatment4completed
NCT05164393
Phase I/IIa Trial to Evaluate AVX001 Gel in Doses of 1% or 3% Compared With Vehicle Over Four Weeks of Field-directed Treatment Period in Adult Subjects With AKtreatment1 / 2unknown_status
NCT02373371
Actinic Keratoses Treatment With Metvix® in Combination With Lighttreatment3completed
NCT01475071
Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratosestreatment3completed
NCT00711178
A Randomized Multicenter Study of Daylight Mediated Photodynamic Therapy (PDT)No drug interventionstreatmentNot Availablecompleted
NCT00558688
A Photodynamic Therapy for Treatment of Actinic KeratosesNo drug interventionstreatmentNot Availablecompleted
NCT03996252
Combination Topical Therapy for Treatment of Scalp Actinic Keratosestreatment0terminated
NCT02520700
A Comparison of White-light and Daylight Topical Methyl 5-aminolaevulinic Acid Photodynamic Therapy for Actinic KeratosesNo drug interventionstreatmentNot Availablecompleted
NCT01053000
Photodynamic Therapy With Levulan® +/- Topical Retinoid Pre-Treatment In The Treatment Of Actinic KeratosestreatmentNot Availablecompleted
NCT04319159
Study to Evaluate the Safety of BF-200 ALA (Ameluz®) for Photodynamic Therapy (PDT) in the Treatment of Expanded Fields of Actinic Keratosis (AK)No drug interventionstreatment1completed
NCT06461442
Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic KeratosisNo drug interventionstreatment4enrolling_by_invitation
NCT05522036
Clinical Evaluation of a Short Illumination Duration (35 Minutes) When Performing PDT of AK Using the Dermaris ®treatmentNot Availablecompleted
NCT05725213
ADL-PDT Under Routine Clinical Conditions in Patients With Actinic KeratosisNot AvailableNot Availablecompleted
NCT04969419
Incidence of Melanoma and Non-melanoma Skin Cancer in People With VitiligoNo drug interventionsNot AvailableNot Availablecompleted
NCT03596619
The Study of Plum-blossom Needling Enhancing Efficacy of Aminolevulinic Acid-photodynamic Therapy for Actinic KeratosisNo drug interventionstreatmentNot Availableunknown_status
NCT05456334
New Treatments for Actinic Keratoses of the ScalptreatmentNot Availableactive_not_recruiting
NCT06026358
Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Handstreatment4withdrawn
NCT03483935
Microwave Therapy for Treatment of Precancerous Actinic KeratosesNo drug interventionstreatmentNot Availablecompleted
NCT03315286
Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet ExposureNo drug interventionspreventionNot Availablecompleted
NCT04842422
Earliest Stage Treatment of Aktinic Keratosis With Imiquimod 3.75% Creamtreatment4completed
NCT03606122
5-ALA Patch-PDT of Actinic Keratosis on the Upper Extremitiestreatment2completed
NCT03511326
PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AKother4completed
NCT06274320
Effect of Lipikar Urea 30% Before Actinic Keratoses TreatmentNo drug interventionssupportive_careNot Availablerecruiting
NCT01502020
A Bioequivalence Study With Clinical Endpoints Comparing Generic Imiquimod Cream, 3.75% and Zyclara™ (Imiquimod) Cream, 3.75% in Subjects With Actinic KeratosestreatmentNot Availablecompleted
NCT01935531
Effects of Topical Diclofenac on Tumor Metabolismbasic_science4completed
NCT00377273
An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratosestreatment4completed
NCT05078827
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosistreatment3completed
NCT00742391
A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locationstreatment3completed
NCT00829192
Phase II AK Study in Organ Transplant Patientsprevention2unknown_status
NCT06385340
Investigation of the Effect of Lipikar Baume AP+MNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT01538901
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipientstreatment4terminated
NCT00942604
A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locationstreatment3completed
NCT05740969
Gene and Protein Expression Profiles After Treatment of Actinic Keratosestreatment2recruiting
NCT03246412
Nevus Doctor Clinical Decision Support for GPsNo drug interventionsdiagnosticNot Availablecompleted
NCT00427050
A Study to Determine the Optimal Tolerated Regime and Safety of PEP005 Topical Geltreatment2completed
NCT03826550
Therapeutic Equivalence of Diclofenac Sodium Gel 3% vs Solaraze ® in the Treatment of Actinic Keratosistreatment3completed
NCT03066843
Photodynamic Therapy Incubation Times for Actinic KeratosisNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT00175643
Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratosestreatment3completed
NCT06321003
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence TomographyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06428721
The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric PopulationNo drug interventionspreventionNot Availablerecruiting
NCT05662202
Study to Evaluate the Safety, Tolerability and Efficacy of BF-200 ALA (Ameluz®) in the Field-directed Treatment of Actinic Keratosis (AK) on the Extremities and Neck/Trunk With Photodynamic Therapy (PDT) Using a RhodoLED LampNo drug interventionstreatment3recruiting
NCT02451579
A Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic TherapytreatmentNot Availablecompleted
NCT04024579
Treatment of Actinic Keratosis With 5% KOH SolutionNo drug interventionsNot AvailableNot Availablecompleted
NCT00668733
Follow-up Study to Evaluate Sustained Clearance Rates of Actinic Keratoses up to One YearNo drug interventionsNot AvailableNot Availablecompleted
NCT00189254
A Study to Follow up Recurrence Rates of Actinic Keratoses One Year After Completion of Study 1487-IMIQNot AvailableNot Availablecompleted
NCT02411851
Treatment of Actinic Keratoses (AK) on the Facetreatment1completed
NCT04843553
Nicotinamide for Prevention of Pre-malignant Actinic Keratosis in Kidney Transplant Recipientsprevention0completed
NCT03906253
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic NeoplasiaNo drug interventionspreventionNot Availablerecruiting
NCT01532453
Prevention of UV-induced Carcinogenic Skin Alterations in Immunosuppressed Solid Organ Transplanted PatientsNo drug interventionsprevention3terminated
NCT04814953
HRQoL Keratinocyte CarcinomasNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04527653
Evaluation of The Efficacy and Safety of Tixel Treatment for the Treatment of Facial and/or Scalp Actinic KeratosesNo drug interventionstreatmentNot Availablecompleted
NCT05987553
The Influence of an E-learning Program on Recognition of Actinic KeratosisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00948428
Bioequivalence of Generic Imiquimod Cream, 5% When Compared to Aldara™ (Imiquimod) Cream, 5% in the Treatment of Actinic Keratosistreatment3completed
NCT03322293
Daylight Photodynamic Therapy for Actinic Keratosistreatment1completed
NCT06008171
Patient Decision Aid for the Treatment of Actinic KeratosisNo drug interventionsotherNot Availablerecruiting
NCT00865878
ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipientstreatment2terminated
NCT00756288
Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic KeratosesNo drug interventionstreatmentNot Availablewithdrawn
NCT06499415
Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic Keratosistreatment4not_yet_recruiting
NCT02251652
Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratosestreatment4completed
NCT02149342
Daylight-mediated Photodynamic Therapy of Actinic Keratoses:Comparing 0.2%HAL With 16%MALtreatment1 / 2completed
NCT01354717
Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebotreatment3completed
NCT00432224
Treatment of Actinic Keratoses With Photodynamic Therapy Using Sunlight Versus Red LightNo drug interventionstreatmentNot Availablecompleted
NCT06545396
Efficacy And Safety Of Illumination Dose Reduction In Red Light Photodynamic Therapy For Actinic KeratosesNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00544258
Pharmacokinetic Study to Evaluate the Extent of Systemic Absorption of PEP005treatment1completed
NCT03642535
Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Preventionprevention4recruiting
NCT05365386
Efficacy and Safety of Tixel Treatment on Facial and/or Scalp Actinic Keratoses.No drug interventionstreatmentNot Availablecompleted
NCT05976048
Implementation of Actinic Keratosis Guideline Among General Practitioners.No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04875026
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trialsupportive_care4completed
NCT00605176
Safety and Effectiveness Study of Imiquimod Creams for Treatment of Actinic Keratoses (AKs)treatment3completed
NCT05202860
Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients With Actinic KeratosisNo drug interventionstreatment2active_not_recruiting
NCT05923060
Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratosesprevention2not_yet_recruiting
NCT02736760
Daylight-PDT With MAL for AK and Photodamaged SkinNo drug interventionstreatment4completed
NCT02622594
Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Timestreatment4completed
NCT00786994
The Efficacy and Tolerability of Oleogel-S-10 in Patients With Actinic Keratosestreatment2completed
NCT01821391
Phase 3b Study of Metvix NDL-PDT Versus Metvix c-PDT in Subjects With Actinic Keratosestreatment3completed
NCT04809662
Comparing Immune Responses to Topical ImiquimodNot AvailableNot Availableunknown_status
NCT03575780
Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosistreatment1completed
NCT05937529
Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic KeratosisNo drug interventionstreatmentNot Availablecompleted
NCT06507644
Methyl Aminolevulinate 8% and 16% Incubated by 1 and 3 for Actinic Keratoses TreatmentNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04085367
Multicenter Study to Assess the Efficacy and Safety of Methyl Aminolevulinate Hydrochloride (MAL) 16.8% Cream (CD06809-41) Versus Vehicle Cream for Actinic Keratosis of the FaceNo drug interventionstreatment3completed
NCT04429308
PDT vs Peels for Treatment of Actinic KeratosesNo drug interventionstreatment2not_yet_recruiting
NCT04482322
Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic KeratosesNo drug interventionstreatmentNot Availablerecruiting