Keratolytic Agents

Name
Keratolytic Agents
Accession Number
DBCAT000884
Description

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.

Drugs
DrugDrug Description
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
Benzoyl peroxideAn antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea.
Coal tarRelieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.
EtretinateFor the treatment of severe psoriasis in adults.
Glycolic acidNot Available
OctasulfurAn ingredient of various cosmetic preparations for its keratolytic, antifungal, and antibacterial properties.
PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
PodophyllinA cytotoxic agent used for the removal of soft genital (venereal) warts (condylomata acuminata).
PyrithioneAn antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.
Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
TretinoinA vitamin A derivative used to treat acne vulgaris and certain types of promyelocytic leukemia, as well as various skin conditions in over-the-counter medications.
UreaA keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.
Drugs & Drug Targets
DrugTargetType
AcitretinSignal transducer and activator of transcription 3target
AcitretinRetinoic acid receptor RXRtarget
AcitretinRetinol-binding protein 1target
AcitretinAlbumincarrier
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor alphatarget
Benzoyl peroxideSuperoxide Dismutasestarget
Benzoyl peroxideGlutathione peroxidasetarget
Benzoyl peroxideProtein kinase Ctarget
Benzoyl peroxideAntizyme inhibitor 2target
Benzoyl peroxideCatalasetarget
Benzoyl peroxideCatalaseenzyme
Coal tarAryl hydrocarbon receptortarget
EtretinateRetinoic acid receptor betatarget
EtretinateRetinoic acid receptor RXR-gammatarget
EtretinateRetinoic acid receptor RXR-alphatarget
EtretinateCellular retinoic acid-binding protein 1carrier
EtretinateAromataseenzyme
EtretinateRetinoic acid receptor gammatarget
EtretinateRetinoic acid receptor RXR-betatarget
EtretinateRetinoic acid receptor alphatarget
Glycolic acidGlucose-6-phosphate 1-dehydrogenasetarget
PodofiloxDNA topoisomerase 2-alphatarget
PodofiloxTubulin alpha-4A chaintarget
PodofiloxTubulin beta chaintarget
PodofiloxDNA topoisomerase 2-betatarget
PodophyllinTubulintarget
PyrithionePotassium voltage-gated channel subfamily KQT member 1target
Salicylic acidAlbumincarrier
Salicylic acidProstaglandin G/H synthase 1target
Salicylic acidProstaglandin G/H synthase 2target
Salicylic acidAldo-keto reductase family 1 member C1target
Salicylic acidSolute carrier family 22 member 6transporter
Salicylic acidSolute carrier family 22 member 10transporter
Salicylic acidOrganic anion transporter 3transporter
Salicylic acidSolute carrier family 22 member 11transporter
Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
Salicylic acidMonocarboxylate transporter 1transporter
Salicylic acidSolute carrier family 22 member 7transporter
Salicylic acidCytochrome P450 2C9enzyme
Salicylic acidCarbonic anhydrase 6target
Salicylic acidCarbonic anhydrase 12target
Salicylic acidCarbonic anhydrase 2target
Salicylic acidCarbonic anhydrase 4target
Salicylic acidCarbonic anhydrase 1target
TazaroteneRetinoic acid receptor gammatarget
TazaroteneCytochrome P450 2C8enzyme
TazaroteneRetinoic acid receptor betatarget
TazaroteneRetinoic acid receptor RXR-betatarget
TazaroteneRetinoic acid receptor alphatarget
Tretinoin[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialtarget
TretinoinRetinoic acid receptor RXR-alphatarget
TretinoinCarcinoembryonic antigentarget
TretinoinUDP-glucuronosyltransferase 2B7enzyme
TretinoinCytochrome P450 2E1enzyme
TretinoinCytochrome P450 26A1enzyme
TretinoinCellular retinoic acid-binding protein 1target
TretinoinAlbumincarrier
TretinoinRetinol-binding protein 4target
TretinoinRetinoic acid receptor RXR-gammatarget
TretinoinOdorant-binding protein 2atarget
TretinoinLipocalin-1target
TretinoinAldehyde dehydrogenase 1A1target
TretinoinRetinoic acid receptor RXR-betatarget
TretinoinRetinoic acid receptor gammatarget
TretinoinRetinoic acid receptor betatarget
TretinoinRetinoic acid receptor alphatarget
TretinoinCytochrome P450 1A1enzyme
TretinoinRetinoic acid-induced protein 3target
TretinoinCytochrome P450 2C9enzyme
TretinoinCytochrome P450 2C18enzyme
TretinoinCytochrome P450 3A7enzyme
TretinoinCytochrome P450 2A6enzyme
TretinoinCytochrome P450 3A5enzyme
TretinoinCytochrome P450 3A4enzyme
TretinoinCytochrome P450 2B6enzyme
TretinoinCytochrome P450 4A11enzyme
TretinoinRetinal dehydrogenase 2target
TretinoinRetinoic acid receptor responder protein 1target
TretinoinCytochrome P450 2C8enzyme
TretinoinCellular retinoic acid-binding protein 1transporter
TretinoinCellular retinoic acid-binding protein 2transporter
UreaDihydrofolate reductasetarget
UreaUrea transporter 1transporter
UreaUrea transporter 2transporter
UreaProtein-methionine-sulfoxide reductase catalytic subunit MsrPtarget
UreaCatenin beta-1target
UreaCarbonic anhydrase 2target
UreaArginase-1target