Cholagogues and Choleretics

Name
Cholagogues and Choleretics
Accession Number
DBCAT001385
Description

Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).

Drugs
DrugDrug Description
Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
Deoxycholic acidA cytolytic agent injected subcutaneously to improve the appearance submental fat.
Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
Ferulic acidNot Available
Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis,...
CholecystokininFor use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency .
Dehydrocholic acidNo approved therapeutic indications.
TritoqualineNot Annotated
EpomediolNot Annotated
Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
Drugs & Drug Targets
DrugTargetType
Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
Ursodeoxycholic acidBile salt export pumptransporter
Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
Ursodeoxycholic acidSodium/bile acid cotransportertransporter
Ursodeoxycholic acidBile acid receptortarget
Ursodeoxycholic acidCytochrome P450 3A Subfamilyenzyme
Deoxycholic acidBile salt export pumptransporter
Deoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Deoxycholic acidIleal sodium/bile acid cotransportertransporter
Deoxycholic acidSodium/bile acid cotransportertransporter
Deoxycholic acidSteroid Delta-isomerasetarget
Deoxycholic acidPpcAtarget
Deoxycholic acidElongation factor Tu GTP-binding domain-containing protein 1target
Deoxycholic acidCholoylglycine hydrolasetarget
Deoxycholic acidLactaldehyde dehydrogenasetarget
Deoxycholic acidAcriflavine resistance protein Btarget
Deoxycholic acidCytochrome c oxidase subunit 1target
Deoxycholic acidCytochrome c oxidase subunit 2target
Deoxycholic acidBile acid receptortarget
Deoxycholic acidGlutathione S-transferase Ptarget
Deoxycholic acidG-protein coupled bile acid receptor 1target
Taurocholic acidBile salt-activated lipasetarget
Taurocholic acidGastrotropintarget
Taurocholic acidBile salt export pumptransporter
Taurocholic acidMultidrug resistance-associated protein 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurocholic acidIleal sodium/bile acid cotransportertransporter
Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
Taurocholic acidMultidrug resistance-associated protein 4transporter
Taurocholic acidP-glycoprotein 1transporter
Taurocholic acidSolute carrier family 22 member 6transporter
Taurocholic acidMultidrug resistance-associated protein 7transporter
Taurocholic acidSolute carrier family 22 member 8transporter
Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
Taurocholic acidATP-binding cassette sub-family C member 11transporter
Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
Taurocholic acidATP-binding cassette sub-family G member 2transporter
Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
Taurocholic acidMonocarboxylate transporter 1transporter
Taurocholic acidSodium/bile acid cotransportertransporter
Taurocholic acidOrganic solute transporter subunit alphatransporter
Taurocholic acidOrganic solute transporter subunit betatransporter
Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
Taurocholic acidCystine/glutamate transportertransporter
Taurocholic acidBile acid receptortarget
Ferulic acidEndo-1,4-beta-xylanase Ytarget
Ferulic acidEndo-1,4-beta-xylanase Ztarget
Ferulic acidEst1etarget
Ferulic acidO-methyltransferasetarget
Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurochenodeoxycholic acidCystine/glutamate transportertransporter
Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Tauroursodeoxycholic acidCystine/glutamate transportertransporter
Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
CholecystokininSolute carrier organic anion transporter family member 1B3transporter
CholecystokininCholecystokinin receptor type Atarget
CholecystokininRAF proto-oncogene serine/threonine-protein kinasetarget
CholecystokininMitogen-activated protein kinase 3target
CholecystokininPro-epidermal growth factortarget
CholecystokininProtein kinase C beta typetarget
CholecystokininGastrin/cholecystokinin type B receptortarget
CholecystokininSolute carrier organic anion transporter family member 1B1transporter
CholecystokininSolute carrier organic anion transporter family member 2B1transporter
Glycocholic acidGastrotropintarget
Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter