MK-212

Identification

Generic Name

MK-212

DrugBank Accession Number

DB12111

Background

MK-212 has been used in trials studying the treatment of Alcoholism.

Type

Small Molecule

Groups

Investigational

Structure

3D

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MOLSDF3D-SDFPDBSMILESInChI

Similar Structures

Structure for MK-212 (DB12111)

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Weight

Average: 198.65
Monoisotopic: 198.0672241

Chemical Formula

C₈H₁₁ClN₄

Synonyms

• CPP

External IDs

• NSC-317326

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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1,2-Benzodiazepine	The risk or severity of CNS depression can be increased when MK-212 is combined with 1,2-Benzodiazepine.
Acenocoumarol	The risk or severity of adverse effects can be increased when MK-212 is combined with Acenocoumarol.
Acetazolamide	The risk or severity of CNS depression can be increased when Acetazolamide is combined with MK-212.
Acetophenazine	The risk or severity of CNS depression can be increased when Acetophenazine is combined with MK-212.
Agomelatine	The risk or severity of CNS depression can be increased when Agomelatine is combined with MK-212.
Alfentanil	The risk or severity of CNS depression can be increased when Alfentanil is combined with MK-212.
Alimemazine	The risk or severity of CNS depression can be increased when Alimemazine is combined with MK-212.
Almotriptan	The risk or severity of CNS depression can be increased when Almotriptan is combined with MK-212.
Alosetron	The risk or severity of CNS depression can be increased when Alosetron is combined with MK-212.
Alprazolam	The risk or severity of CNS depression can be increased when Alprazolam is combined with MK-212.

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Food Interactions

Not Available

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
MK-212 hydrochloride	8722D514RX	61655-58-1	PFIZGLUIYAZQFU-UHFFFAOYSA-N

Categories

Drug Categories

• Antidepressive Agents
• Central Nervous System Depressants
• Neurotransmitter Agents
• Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
• Serotonin Agents
• Serotonin Receptor Agonists

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Diazinanes

Sub Class

Piperazines

Direct Parent

N-arylpiperazines

Alternative Parents

Dialkylarylamines / Aminopyrazines / Imidolactams / Aryl chlorides / Heteroaromatic compounds / Dialkylamines / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Hydrocarbon derivatives

Substituents

Amine / Aminopyrazine / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Dialkylarylamine / Heteroaromatic compound / Hydrocarbon derivative / Imidolactam

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Affected organisms

Not Available

Chemical Identifiers

UNII

62C3N7238U

CAS number

64022-27-1

InChI Key

CJAWPFJGFFNXQI-UHFFFAOYSA-N

InChI

InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2

IUPAC Name

2-chloro-6-(piperazin-1-yl)pyrazine

SMILES

ClC1=NC(=CN=C1)N1CCNCC1

References

General References

Not Available

External Links

PubChem Compound

107992

PubChem Substance

347828412

ChemSpider

97104

BindingDB

50017452

ChEBI

92360

ChEMBL

CHEMBL269521

ZINC

ZINC000001571800

Wikipedia

MK-212

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	1.03 mg/mL	ALOGPS
logP	0.97	ALOGPS
logP	0.53	Chemaxon
logS	-2.3	ALOGPS
pKa (Strongest Basic)	8.73	Chemaxon
Physiological Charge	1	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	1	Chemaxon
Polar Surface Area	41.05 Å2	Chemaxon
Rotatable Bond Count	1	Chemaxon
Refractivity	53.11 m3·mol-1	Chemaxon
Polarizability	19.72 Å3	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

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Drug created at October 20, 2016 21:22 / Updated at June 12, 2020 16:53