Radezolid

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Radezolid
DrugBank Accession Number
DB12339
Background

Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 438.463
Monoisotopic: 438.181566788
Chemical Formula
C22H23FN6O3
Synonyms
  • Radezolid
External IDs
  • AND RX-01_667
  • RX-013
  • RX-103
  • RX-1741

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
URibosome-binding protein 1Not AvailableHumans
U60S ribosome subunit biogenesis protein NIP7 homologNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe risk or severity of bleeding can be increased when Radezolid is combined with Acenocoumarol.
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Radezolid.
DicoumarolThe risk or severity of bleeding can be increased when Radezolid is combined with Dicoumarol.
EstetrolThe therapeutic efficacy of Estetrol can be decreased when used in combination with Radezolid.
FluindioneThe risk or severity of bleeding can be increased when Radezolid is combined with Fluindione.
LactuloseThe therapeutic efficacy of Lactulose can be decreased when used in combination with Radezolid.
PhenindioneThe risk or severity of bleeding can be increased when Radezolid is combined with Phenindione.
PhenprocoumonThe risk or severity of bleeding can be increased when Radezolid is combined with Phenprocoumon.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Radezolid.
Typhoid vaccineThe therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Radezolid.
Interactions
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Radezolid hydrochloride37CW568NXL869884-77-5UQKABVKLBIJYBI-FYZYNONXSA-N

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Biphenyls and derivatives
Direct Parent
Biphenyls and derivatives
Alternative Parents
Phenylmethylamines / Benzylamines / Aralkylamines / Fluorobenzenes / Aryl fluorides / Oxazolidinones / Triazoles / Carbamate esters / Heteroaromatic compounds / Dialkylamines
show 8 more
Substituents
1,2,3-triazole / Amine / Aralkylamine / Aromatic heteromonocyclic compound / Aryl fluoride / Aryl halide / Azacycle / Azole / Benzylamine / Biphenyl
show 24 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
53PC6LO35W
CAS number
869884-78-6
InChI Key
BTTNOGHPGJANSW-IBGZPJMESA-N
InChI
InChI=1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1
IUPAC Name
N-{[(5S)-3-[2-fluoro-4'-({[(1H-1,2,3-triazol-5-yl)methyl]amino}methyl)-[1,1'-biphenyl]-4-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
SMILES
CC(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C(F)=C1)C1=CC=C(CNCC2=CN=NN2)C=C1

References

General References
Not Available
PubChem Compound
11224409
PubChem Substance
347828598
ChemSpider
9399462
ChEMBL
CHEMBL455461
ZINC
ZINC000040379938
PDBe Ligand
RD8
Wikipedia
Radezolid
PDB Entries
6wqq

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAbscesses / Skin Diseases, Bacterial / Skin Diseases, Infectious / Staphylococcal Skin Infections / Streptococcal Infections1
2CompletedTreatmentCommunity Acquired Pneumonia (CAP)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.043 mg/mLALOGPS
logP1.23ALOGPS
logP1.29ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)8.56ChemAxon
pKa (Strongest Basic)7.46ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area112.24 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity115.89 m3·mol-1ChemAxon
Polarizability45.19 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Receptor activity
Specific Function
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
Gene Name
RRBP1
Uniprot ID
Q9P2E9
Uniprot Name
Ribosome-binding protein 1
Molecular Weight
152471.765 Da
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Poly(a) rna binding
Specific Function
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
Gene Name
NIP7
Uniprot ID
Q9Y221
Uniprot Name
60S ribosome subunit biogenesis protein NIP7 homolog
Molecular Weight
20462.485 Da

Drug created on October 20, 2016 22:00 / Updated on February 21, 2021 18:53