Accession Number

Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.

DrugDrug Description
ZolmitriptanA member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults.
TrimethadioneAn anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.
PemolineA central nervous system (CNS) stimulant that was previously used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
AminorexAminorex is an amphetamine-like anorectic agent. It may cause pulmonary hypertension.
Azilsartan medoxomilAn angiotensin II receptor blocker used to treat hypertension alone or in combination with other antihypertensive agents, such as chlorthalidone.
OpicaponeA catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor.
MuscimolMuscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease.
OzanimodA sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
TedizolidAn oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections.
OxaprozinAn NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
RilmenidineAn I1-imidazoline receptor agonist used to treat hypertension.
CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
FurazolidoneA drug for the treatment of infectious diarrhea.
MetaxaloneA muscle relaxant used to treat muscle pain or spasm.
4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acidNot Available
Quisqualic acidQuisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular...
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-OxadiazoleNot Available
FreselestatInvestigated for use/treatment in chronic obstructive pulmonary disease (COPD).
PosizolidFor the treatment of gram-positive infections, including multiresistant strains.
AtalurenA medication used for the treatment of Duchenne muscular dystrophy.
PleconarilInvestigated for use/treatment in upper respiratory infection.
AnacetrapibInvestigated for use/treatment in hyperlipidemia.
ToloxatoneFor the treatment of major depressive disorder.
MolsidomineA long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction.
ImolamineImolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic.
AmenamevirAmenamevir has been used in trials studying the treatment of Herpes Zoster, Herpes Simplex, Herpes Genitalis, and Safety of Amenamevir.
ASP-4058ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058.
CadazolidCadazolid has been used in trials studying the treatment of Clostridium Difficile Infection.
AvagacestatAvagacestat has been investigated for the basic science and treatment of Alzheimer Disease.
SutezolidSutezolid has been used in trials studying the treatment of Tuberculosis.
GSK-2018682GSK2018682 has been investigated for the treatment of Multiple Sclerosis, Relapsing-Remitting.
RadezolidRadezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.
VerucerfontVerucerfont has been used in trials studying the treatment of Congenital Adrenal Hyperplasia.
GSK-356278Gsk356278 has been used in trials studying the treatment and basic science of Anxiety Disorders, Huntington Disease, Depressive Disorder, Huntingtons Disease, and Depressive Disorder, Major, among others.
CenerimodCenerimod has been used in trials studying the treatment of Systemic Lupus Erythematosus.
GSK-690693GSK690693 has been used in trials studying the treatment of Tumor, CANCER, and Lymphoma.
ZoliflodacinZoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea.
TerizidoneTerizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis.
DelpazolidDelpazolid (LCB01-0371) is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study).
OxolamineA medication indicated in the treatment of a cough or upper respiratory tract inflammation.
FenozoloneNot Annotated
LinsidomineNot Annotated
ButalamineNot Annotated
NifuratelA nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections.
ProxazoleNot Annotated
RAD-140RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
FarampatorFarampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression).
LisavanbulinLisavanbulin is under investigation in clinical trial NCT02895360 (Phase 1/2a Study of BAL101553 as 48-hour Infusions in Patients With Advanced Solid Tumors or Recurrent Glioblastoma).
RovatirelinRovatirelin is under investigation in clinical trial NCT01384435 (A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)).
BTRX-335140BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo).
AZD8529AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients).
VafidemstatVafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease).
FuraltadoneIndicated in combination with other drugs for the treatment of otitis media and externa.
CDD-0102Not Annotated
GSK-269962AGSK-269962A is a Rho kinase (ROCK) inhibitor with both ROCK1 and ROCK2 affinity.
IOWH-032Iowh032 has been investigated for the treatment of Cholera, Diarrhea, and Secretory Diarrhea.
CevidoplenibNot Annotated
Drugs & Drug Targets
Zolmitriptan5-hydroxytryptamine receptor 1Dtarget
Zolmitriptan5-hydroxytryptamine receptor 1Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Ftarget
ZolmitriptanCytochrome P450 1A2enzyme
ZolmitriptanAmine oxidase [flavin-containing] Aenzyme
Zolmitriptan5-hydroxytryptamine receptor 1Atarget
ZolmitriptanP-glycoprotein 1transporter
Zolmitriptan5-hydroxytryptamine receptor 7target
Zolmitriptan5-hydroxytryptamine receptor 2Atarget
Zolmitriptan5-hydroxytryptamine receptor 2Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Etarget
TrimethadioneVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
TrimethadioneCytochrome P450 2C19enzyme
TrimethadioneCytochrome P450 2C8enzyme
TrimethadioneCytochrome P450 2C9enzyme
TrimethadioneCytochrome P450 2E1enzyme
TrimethadioneCytochrome P450 3A4enzyme
Azilsartan medoxomilType-1 angiotensin II receptortarget
Azilsartan medoxomilSerum albumincarrier
Azilsartan medoxomilCytochrome P450 2C9enzyme
Azilsartan medoxomilCytochrome P450 2C8enzyme
Azilsartan medoxomilCytochrome P450 2B6enzyme
Azilsartan medoxomilP-glycoprotein 1transporter
OpicaponeCytochrome P450 2C19enzyme
OpicaponeCytochrome P450 2C8enzyme
OpicaponeCatechol O-methyltransferasetarget
OpicaponeSolute carrier organic anion transporter family member 1B1transporter
OpicaponeP-glycoprotein 1transporter
OpicaponeATP-binding cassette sub-family G member 2transporter
OpicaponeSolute carrier organic anion transporter family member 1B3transporter
OpicaponeSolute carrier organic anion transporter family member 2B1transporter
OpicaponeCytochrome P450 2C9enzyme
OpicaponeCytochrome P450 1A2enzyme
OpicaponeCytochrome P450 2B6enzyme
MuscimolGamma-aminobutyric acid receptor subunit alpha-1target
MuscimolGamma-aminobutyric acid receptor subunit beta-3target
MuscimolGamma-aminobutyric acid receptor subunit gamma-2target
OzanimodSphingosine 1-phosphate receptor 1target
OzanimodSphingosine 1-phosphate receptor 5target
OzanimodAmine oxidase [flavin-containing] Btransporter
OzanimodATP-binding cassette sub-family G member 2transporter
OzanimodP-glycoprotein 1transporter
OzanimodFatty aldehyde dehydrogenaseenzyme
OzanimodAlcohol dehydrogenase class-3enzyme
OzanimodArylamine N-acetyltransferase 2enzyme
OzanimodCytochrome P450 2C8enzyme
OzanimodAmine oxidase [flavin-containing] Benzyme
OzanimodAldo-keto reductase family 1 member C1enzyme
OzanimodAldo-keto reductase family 1 member C2enzyme
OzanimodCytochrome P450 3A4enzyme
Tedizolid23S ribosomal RNAtarget
TedizolidAmine oxidase [flavin-containing] Aenzyme
TedizolidAmine oxidase [flavin-containing] Benzyme
OxaprozinProstaglandin G/H synthase 2target
OxaprozinProstaglandin G/H synthase 1target
RilmenidineAlpha-2A adrenergic receptortarget
CycloserineD-alanine--D-alanine ligase Atarget
CycloserineAlanine racemasetarget
CycloserineAromatic-L-amino-acid decarboxylaseenzyme
CycloserineProton-coupled amino acid transporter 2transporter
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acidL-lactate dehydrogenasetarget
4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acidL-lactate dehydrogenase B chaintarget
Quisqualic acidGlutamate receptor 2target
Quisqualic acidGlutamate receptor ionotropic, kainate 2target
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-OxadiazoleGlycogen phosphorylase, muscle formtarget
FreselestatChymotrypsin-like elastase family member 1target
FreselestatNeutrophil elastasetarget
Posizolid23S ribosomal RNAtarget
PosizolidAmine oxidase [flavin-containing] Atarget
PosizolidSolute carrier organic anion transporter family member 1B1transporter
AtalurenUDP-glucuronosyltransferase 1-9enzyme
AtalurenSolute carrier family 22 member 6enzyme
AtalurenSolute carrier family 22 member 8enzyme
AtalurenSolute carrier organic anion transporter family member 1B3enzyme
ToloxatoneAmine oxidase [flavin-containing] Atarget
ToloxatoneAmine oxidase [flavin-containing] Aenzyme
MolsidomineGuanylate cyclase soluble subunit alpha-2target
MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
RadezolidRibosome-binding protein 1target
Radezolid50S ribosomal protein L1target
VafidemstatAmine oxidase [flavin-containing] Btarget
VafidemstatLysine-specific histone demethylase 1Atarget