- Accession Number
Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.
Drug Drug Description Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Pemoline A central nervous system (CNS) stimulant that was previously used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Aminorex Aminorex is an amphetamine-like anorectic agent. It may cause pulmonary hypertension. Azilsartan medoxomil An angiotensin II receptor blocker used to treat hypertension alone or in combination with other antihypertensive agents, such as chlorthalidone. Opicapone A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor. Muscimol Muscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease. Ozanimod A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD). Tedizolid An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Rilmenidine An I1-imidazoline receptor agonist used to treat hypertension. Cycloserine A broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). Furazolidone A drug for the treatment of infectious diarrhea. Metaxalone A muscle relaxant used to treat muscle pain or spasm. 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid Not Available Quisqualic acid Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular... 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole Not Available Freselestat Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Posizolid For the treatment of gram-positive infections, including multiresistant strains. Ataluren A medication used for the treatment of Duchenne muscular dystrophy. Pleconaril Investigated for use/treatment in upper respiratory infection. Anacetrapib Investigated for use/treatment in hyperlipidemia. Toloxatone For the treatment of major depressive disorder. Molsidomine A long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction. Imolamine Imolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic. Amenamevir Amenamevir has been used in trials studying the treatment of Herpes Zoster, Herpes Simplex, Herpes Genitalis, and Safety of Amenamevir. ASP-4058 ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058. Cadazolid Cadazolid has been used in trials studying the treatment of Clostridium Difficile Infection. Avagacestat Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease. Sutezolid Sutezolid has been used in trials studying the treatment of Tuberculosis. GSK-2018682 GSK2018682 has been investigated for the treatment of Multiple Sclerosis, Relapsing-Remitting. Radezolid Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others. Verucerfont Verucerfont has been used in trials studying the treatment of Congenital Adrenal Hyperplasia. GSK-356278 Gsk356278 has been used in trials studying the treatment and basic science of Anxiety Disorders, Huntington Disease, Depressive Disorder, Huntingtons Disease, and Depressive Disorder, Major, among others. Cenerimod Cenerimod has been used in trials studying the treatment of Systemic Lupus Erythematosus. GSK-690693 GSK690693 has been used in trials studying the treatment of Tumor, CANCER, and Lymphoma. Zoliflodacin Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea. Terizidone Terizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis. LCB01-0371 Lcb01 0371 is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study). Oxolamine A medication indicated in the treatment of a cough or upper respiratory tract inflammation. Fenozolone Not Annotated Linsidomine Not Annotated Butalamine Not Annotated Nifuratel A nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections. Proxazole Not Annotated RAD-140 RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer. Farampator Farampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression). Lisavanbulin Lisavanbulin is under investigation in clinical trial NCT02895360 (Phase 1/2a Study of BAL101553 as 48-hour Infusions in Patients With Advanced Solid Tumors or Recurrent Glioblastoma). Rovatirelin Rovatirelin is under investigation in clinical trial NCT01384435 (A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)). BTRX-335140 BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo). AZD8529 AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients). Vafidemstat Vafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease). Furaltadone Indicated in combination with other drugs for the treatment of otitis media and externa.
- Drugs & Drug Targets