Perindoprilat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Perindoprilat
DrugBank Accession Number
DB14213
Background

The active metabolite of the prodrug Perindopril.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 340.4146
Monoisotopic: 340.199822016
Chemical Formula
C17H28N2O5
Synonyms
  • Perindoprilat
  • Perindoprilate
  • Perindoprilato
  • Perindoprilatum
External IDs
  • BRN 4207072
  • S 9780
  • S-9780

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololThe risk or severity of hyperkalemia can be increased when Acebutolol is combined with Perindoprilat.
AceclofenacThe risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Aceclofenac is combined with Perindoprilat.
AcemetacinThe risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Acemetacin is combined with Perindoprilat.
Acetylsalicylic acidThe therapeutic efficacy of Perindoprilat can be decreased when used in combination with Acetylsalicylic acid.
Agrostis gigantea pollenThe risk or severity of adverse effects can be increased when Perindoprilat is combined with Agrostis gigantea pollen.
Agrostis stolonifera pollenThe risk or severity of adverse effects can be increased when Perindoprilat is combined with Agrostis stolonifera pollen.
AlclofenacThe risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Alclofenac is combined with Perindoprilat.
AldesleukinAldesleukin may increase the hypotensive activities of Perindoprilat.
AlfentanilAlfentanil may decrease the antihypertensive activities of Perindoprilat.
AlfuzosinAlfuzosin may increase the hypotensive activities of Perindoprilat.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Dipeptides
Alternative Parents
N-acyl-L-alpha-amino acids / Alpha amino acid amides / L-alpha-amino acids / Indoles and derivatives / Pyrrolidine carboxylic acids / N-acylpyrrolidines / Methyl-branched fatty acids / Heterocyclic fatty acids / Dicarboxylic acids and derivatives / Tertiary carboxylic acid amides
show 8 more
Substituents
Aliphatic heteropolycyclic compound / Alpha-amino acid / Alpha-amino acid amide / Alpha-amino acid or derivatives / Alpha-dipeptide / Amine / Amino acid / Amino acid or derivatives / Azacycle / Branched fatty acid
show 28 more
Molecular Framework
Aliphatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
2UV6ZNQ92K
CAS number
95153-31-4
InChI Key
ODAIHABQVKJNIY-PEDHHIEDSA-N
InChI
InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
IUPAC Name
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-carboxybutyl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
SMILES
[H][C@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC)C(O)=O)[C@@]1([H])CCCC2)C(O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0060574
ChemSpider
65017
RxNav
1546400
ChEBI
132041
ChEMBL
CHEMBL1201368
ZINC
ZINC000004217270
PDBe Ligand
X94
PDB Entries
2x94

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.2 mg/mLALOGPS
logP-0.08ALOGPS
logP-0.85ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)3.08ChemAxon
pKa (Strongest Basic)8.06ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area106.94 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity86.18 m3·mol-1ChemAxon
Polarizability35.8 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on July 04, 2018 19:54 / Updated on February 21, 2021 18:54