Purine Nucleosides

Purine Nucleosides
Accession Number

Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.

DrugDrug Description
VidarabineAn antiviral agent used to treat various viral infections.
CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
AdenosineA medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
GuanosineGuanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP...
TubercidinAn antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic...
InosineA nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting.
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
NebularineNot Available
GS-6620GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection).
GS-441524An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections.
Drugs & Drug Targets
VidarabineDNA polymerase catalytic subunittarget
VidarabineThymidine kinasetarget
VidarabineThymidine kinasetarget
VidarabineAdenosine deaminaseenzyme
CladribinePurine nucleoside phosphorylasetarget
CladribineDeoxycytidine kinaseenzyme
CladribineRibonucleoside-diphosphate reductase large subunittarget
CladribineRibonucleoside-diphosphate reductase subunit M2target
CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
CladribineDNA polymerase alpha catalytic subunittarget
CladribineDNA polymerase epsilon catalytic subunit Atarget
CladribineDNA polymerase epsilon subunit 2target
CladribineDNA polymerase epsilon subunit 3target
CladribineDNA polymerase epsilon subunit 4target
CladribineATP-binding cassette sub-family G member 2transporter
CladribineSolute carrier family 28 member 3transporter
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
AdenosineEquilibrative nucleoside transporter 1transporter
AdenosineEquilibrative nucleoside transporter 2transporter
AdenosineEquilibrative nucleoside transporter 3transporter
AdenosineEquilibrative nucleoside transporter 4transporter
AdenosineSodium/nucleoside cotransporter 1transporter
AdenosineSodium/nucleoside cotransporter 2transporter
AdenosineGap junction alpha-1 proteintransporter
AdenosineAdenylate kinase isoenzyme 1enzyme
AdenosineNucleoside diphosphate kinase Aenzyme
AdenosineNucleoside diphosphate kinase Benzyme
AdenosinePurine nucleoside phosphorylaseenzyme
AdenosineXanthine dehydrogenase/oxidaseenzyme
AdenosineSerum albumincarrier
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
GuanosineDNA polymerasetarget
GuanosinePurine nucleoside phosphorylasetarget
GuanosinePurine nucleoside phosphorylasetarget
TubercidinPurine nucleoside phosphorylase DeoD-typetarget
InosinePurine nucleoside phosphorylasetarget
InosineIAG-nucleoside hydrolasetarget
InosinePurine nucleoside phosphorylase DeoD-typetarget
InosineXanthine dehydrogenase/oxidaseenzyme
InosineSolute carrier family 28 member 3transporter
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2C9enzyme
TicagrelorSerum albumincarrier
TicagrelorCytochrome P450 3A5enzyme
TicagrelorCytochrome P450 2B6enzyme
NebularineAdenosine deaminasetarget
GS-441524Replicase polyprotein 1abtarget
GS-441524RNA-directed RNA polymerase Ltarget