- Purine Nucleosides
- Accession Number
Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.
Drug Drug Description Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Vidarabine An antiviral agent used to treat various viral infections. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Didanosine A reverse transcriptase inhibitor used to treat HIV. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... 5'-S-methyl-5'-thioadenosine Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Deoxycytidylyl-3',5'-guanosine Not Available 7-Methylguanosine Not Available 5'-Fluoro-5'-Deoxyadenosine Not Available Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. 2-Fluoroadenosine Not Available 5-iodotubercidin Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available 3-Deazaadenosine Not Available N(6)-dimethylallyladenine Not Available Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure).
- Drugs & Drug Targets