Accession Number

Lipopeptides with an anionic peptide scaffold.

DrugDrug Description
DaptomycinA cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus.
Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
CaspofunginAn echinocandin used to treat a variety of fungal infections.
MicafunginAn antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation.
OritavancinAn antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria.
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
TelavancinAn antibacterial agent used in the treatment of complicated skin and skin structure infections and types of hospital-acquired bacterial pneumonia.
RezafunginAn echinocandin antifungal indicated in patients over 18 years old who have limited or no alternative options for the treatment of candidemia and invasive candidiasis.
Drugs & Drug Targets
DaptomycinCytoplasmic membranetarget
DaptomycinSerum albumincarrier
DaptomycinAlpha-1-acid glycoprotein 1carrier
DaptomycinLow-density lipoprotein receptorcarrier
DaptomycinSex hormone-binding globulincarrier
DaptomycinP-glycoprotein 1transporter
Polymyxin BBacterial outer membranetarget
Polymyxin BSolute carrier family 15 member 2transporter
CaspofunginSolute carrier family 22 member 1transporter
CaspofunginP-glycoprotein 1transporter
CaspofunginSolute carrier family 22 member 6transporter
CaspofunginSolute carrier organic anion transporter family member 1B1transporter
CaspofunginSolute carrier organic anion transporter family member 1B3transporter
CaspofunginCytochrome P450 3A4enzyme
Caspofungin1,3-beta-glucan synthase component FKS1target
MicafunginArylsulfatase Aenzyme
MicafunginCatechol O-methyltransferaseenzyme
Micafungin1,3-beta-glucan synthase component FKS1target
OritavancinCytochrome P450 3A4enzyme
OritavancinCytochrome P450 2D6enzyme
OritavancinCytochrome P450 2C9enzyme
OritavancinCytochrome P450 2C19enzyme
OritavancinSerum albumincarrier
OritavancinPeptidoglycan precursorstarget
OritavancinBacterial cell wall peptide bridging segmentstarget
OritavancinPentaglycyl bridging segmenttarget
ColistinBacterial outer membranetarget
ColistimethateBacterial outer membranetarget
Rezafungin1,3-beta-glucan synthase component FKS1target
Rezafungin1,3-beta-glucan synthase component GSC2target