Macrophage colony-stimulating factor 1 receptor

BE0000853ProteinHumansCSF1R

Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages... It is acted on by 33 drugs in DrugBank.

Gene name
CSF1R
UniProtKB entry
P07333Swiss-Prot
Cellular location
Cell membrane
Residues / weight
972 residues · 107,983 Da
Also known as
CSF-1 receptor · CSF-1-R · CSF-1R · FMS · M-CSF-R

Resolves to

Protein
UniProtP07333UniProt nameCSF1R_HUMAN
Gene
HGNCHGNC:2433NCBI Gene1436GenBank553224GeneCardsCSF1R
Pharmacology
IUPHAR/GtoPdb1806KEGGhsa:1436
Structure
PDB2I0VPDB2I0YPDB2I1M
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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13Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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122+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Macrophage colony-stimulating factor 1 receptor, how selective are they, and which programs against it are still in active trials?

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